CAS 52079-10-4

O-Desmethylnaproxen

Description:

O-Desmethylnaproxen, with the CAS number 52079-10-4, is a chemical compound that is a metabolite of the nonsteroidal anti-inflammatory drug (NSAID) naproxen. It is characterized by its structural similarity to naproxen, differing primarily by the absence of a methoxy group. This compound exhibits anti-inflammatory and analgesic properties, making it relevant in pharmacological studies. O-Desmethylnaproxen is typically found in biological samples following the administration of naproxen, as it is one of the metabolites produced during the drug's metabolism in the body. The compound is soluble in organic solvents and has a relatively low solubility in water, which is common for many NSAIDs and their metabolites. Its pharmacokinetic profile, including absorption, distribution, metabolism, and excretion, is influenced by factors such as dosage and individual metabolic variations. Research into O-Desmethylnaproxen contributes to understanding the efficacy and safety profiles of naproxen and similar NSAIDs, particularly in relation to their metabolic pathways and potential therapeutic effects.

Formula: C₁₃H₁₂O₃

InChI: InChI=1S/C13H12O3/c1-8(13(15)16)9-2-3-11-7-12(14)5-4-10(11)6-9/h2-8,14H,1H3,(H,15,16)/t8-/m0/s1

InChI key: InChIKey=XWJUDDGELKXYNO-QMMMGPOBSA-N

SMILES: [C@H](C(O)=O)(C)C1=CC2=C(C=C1)C=C(O)C=C2

Synonyms:

• (+)-2-(6-Hydroxy-2-naphthyl)propionic acid
• 6-Hydroxynaproxen
• (αS)-6-Hydroxy-α-methyl-2-naphthaleneacetic acid
• 2-Naphthaleneacetic acid, 6-hydroxy-α-methyl-, (αS)-
• 2-Naphthaleneacetic acid, 6-hydroxy-α-methyl-, (S)-

Desmethyl Naproxen ((S)-2-(6-Hydroxynaphthalen-2-yl)propanoic acid)

CAS: 52079-10-4

Carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides etc, nesoi

Formula: C₁₃H₁₂O₃

Color and Shape: Off-White Crystalline Powder

Molecular weight: 216.07864

Ref: 45-1A10620

O-Desmethylnaproxen

CAS: 52079-10-4

Formula: C₁₃H₁₂O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 216.2326

Ref: IN-DA00DFDJ

(S)-6-O-Desmethylnaproxen

CAS: 52079-10-4

(S)-6-O-Desmethylnaproxen

Purity: 98%

Ref: 54-OR1039760

Naproxen EP Impurity A (O-Desmethyl Naproxen)

CAS: 52079-10-4

Formula: C₁₃H₁₂O₃

Color and Shape: White To Off-White Solid

Molecular weight: 216.24

Ref: 4Z-N-233

(2S)-2-(6-Hydroxynaphthalen-2-yl)propanoic Acid (O-Demethylnaproxen)

Controlled Product

CAS: 52079-10-4

Formula: C₁₃H₁₂O₃

Color and Shape: Neat

Molecular weight: 216.23

Ref: 86-MM0152.06

Naproxen-O-desmethyl

Controlled Product

CAS: 52079-10-4

Formula: C₁₃H₁₂O₃

Color and Shape: White

Molecular weight: 216.23

Ref: 04-C15483600

O-Desmethylnaproxen

CAS: 52079-10-4

Formula: C₁₃H₁₂O₃

Molecular weight: 216.23

Ref: 7W-GL6106

Naproxen EP Impurity A

CAS: 52079-10-4

Formula: C₁₃H₁₂O₃

Molecular weight: 216.24

Ref: ST-EA-CP-N2001

(S)-O-Desmethyl Naproxen

Controlled Product

CAS: 52079-10-4

Applications A metabolite of Naproxen.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rettie, A., et al.: Chem. Res. Toxicol., 5, 54 (1992), Tracy, T., et al.: Biochem. Pharmacol., 52, 1305 (1996), Bonnabry, P., et al.: Eur. J. Clin. Pharmacol., 49, 305 (1996), Rao, S., et al.: J. Med. Chem., 43, 2789 (2000), Hutzler, J., et al.: Drug Metab. Dispos., 29, 1029 (2001),

Formula: C₁₃H₁₂O₃

Color and Shape: White

Molecular weight: 216.23

Ref: TR-D292125

(S)-O-Desmethylnaproxen

CAS: 52079-10-4

(S)-O-Desmethylnaproxen is a nonsteroidal anti-inflammatory drug (NSAID) that belongs to the group of p-hydroxybenzoic acid derivatives. It has significant cytotoxicity against various bacterial strains and has been shown to be an effective inhibitor of mitochondrial membrane potential. This NSAID also inhibits the production of prostaglandin E2, which is involved in the inflammatory process. (S)-O-Desmethylnaproxen is metabolized by CYP450 enzymes and undergoes phase I metabolism by oxidation to form hydroxy naproxen, which is then conjugated with glucuronic acid and eliminated in urine. The substrate for this drug is naproxen, which can be found in many plants such as parsley and celery. (S)-O-Desmethylnaproxen has been shown to have a matrix effect on hl-60 cells, which may be due to its ability to inhibit protein synthesis

Formula: C₁₃H₁₂O₃

Purity: Min. 95%

Molecular weight: 216.23 g/mol

Ref: 3D-FD21298

(S)-O-Desmethyl Naproxen

CAS: 52079-10-4

(S)-O-Desmethyl naproxen, a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (+)-naproxen ((S)-naproxen), is produced through the action of cytochrome P450 (CYP) isoforms CYP1A2 and CYP2C9.

Formula: C₁₃H₁₂O₃

Color and Shape: Solid

Molecular weight: 216.23

Ref: TM-T84994