CAS 52128-35-5

Trimetrexate

Description:

Trimetrexate is a synthetic compound classified as an antifolate and is primarily used in the treatment of certain types of cancer and autoimmune diseases. It functions as a dihydrofolate reductase inhibitor, disrupting folate metabolism and thereby inhibiting DNA synthesis in rapidly dividing cells. This mechanism makes it effective against neoplastic cells. Trimetrexate is often administered in combination with other chemotherapeutic agents to enhance its efficacy. The compound is characterized by its solubility in water and its ability to penetrate cellular membranes, which facilitates its action within the cell. It has a relatively low molecular weight and is typically administered intravenously due to its pharmacokinetic properties. Side effects may include myelosuppression, gastrointestinal disturbances, and potential hepatotoxicity, necessitating careful monitoring during treatment. Overall, trimetrexate represents an important therapeutic option in oncology, particularly for patients who may not respond to traditional methotrexate therapy.

Formula: C₁₉H₂₃N₅O₃

InChI: InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24)

InChI key: InChIKey=NOYPYLRCIDNJJB-UHFFFAOYSA-N

SMILES: CC=1C2=C(C=CC1CNC3=CC(OC)=C(OC)C(OC)=C3)N=C(N)N=C2N

Synonyms:

• 2,4-Diamino-5-methyl-6-[(3',4',5'-trimethoxyanilino)methyl]quinazoline
• 2,4-Diamino-5-methyl-6-[(3′,4′,5′-trimethoxyanilino)methyl]quinazoline
• 5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediamine
• Ci 898
• Jb 11
• Nsc 249008
• Nsc 352122
• TMQ
• Trimetrexate
• 2,4-Quinazolinediamine, 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-
• Trimetrexato
• HSDB 6545
• Trimetrexatum
• Trimetrexatum [INN-Latin]
• 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]quinazoline-2,4-diamine trihydrochloride
• Trimetrexato [INN-Spanish]
• UNII-UPN4ITI8T4
• 2,4-Quinazolinediamine, 5-methyl-6-(((3,4,5-trimethoxyphenyl)amino)methyl)-

Trimetrexate

Controlled Product

CAS: 52128-35-5

Formula: C₁₉H₂₃N₅O₃

Color and Shape: Neat

Molecular weight: 369.418

Ref: TR-T798205

Trimetrexate

CAS: 52128-35-5

Trimetrexate is an effective competitive inhibitor of bacterial, protozoan, and mammalian dihydrofolate reductase.

Formula: C₁₉H₂₃N₅O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 369.42

Ref: TM-T17164