CAS 52130-25-3

5-Hydroxydantrolene

Description:

5-Hydroxydantrolene, with the CAS number 52130-25-3, is a chemical compound that belongs to the class of dantrolene derivatives. It is primarily recognized for its role in pharmacology, particularly in the treatment of conditions related to muscle spasticity and malignant hyperthermia. The compound features a hydroxyl group (-OH) that contributes to its solubility and reactivity. Its molecular structure includes a hydantoin ring, which is characteristic of dantrolene analogs, and this structure is crucial for its biological activity. 5-Hydroxydantrolene exhibits a mechanism of action that involves the modulation of calcium release from the sarcoplasmic reticulum in muscle cells, thereby affecting muscle contraction. The compound is typically studied for its potential therapeutic applications and may also be evaluated for its safety profile and pharmacokinetics. As with many pharmaceutical compounds, its efficacy and safety are subject to rigorous testing in clinical settings. Overall, 5-Hydroxydantrolene represents an important area of research in muscle-related disorders.

Formula: C₁₄H₁₀N₄O₆

InChI: InChI=1/C14H10N4O6/c19-12-13(20)17(14(21)16-12)15-7-10-5-6-11(24-10)8-1-3-9(4-2-8)18(22)23/h1-7,13,20H,(H,16,19,21)/b15-7+

Synonyms:

• 5-Hydroxy-1-(((5-(4-nitrophenyl)-2-furanyl)methylene)amino)-2,4-imidazolidinedione
• Brn 0899668
• 2,4-Imidazolidinedione, 5-hydroxy-1-(((5-(4-nitrophenyl)-2-furanyl)methylene)amino)-
• 5-hydroxy-1-({(E)-[5-(4-nitrophenyl)furan-2-yl]methylidene}amino)imidazolidine-2,4-dione
• 5-25-02-00378 (Beilstein Handbook Reference)
• 2,4-IMIDAZOLIDINEDIONE
• 5-hydroxy-1-(((5-(4-nitrophenyl)-2-furanyl)methylene)amino)-2,4-imidazolidin
• 2,4-imidazolidinedione,5-hydroxy-1-(((5-(4-nitrophenyl)-2-furanyl)methylene)am
• 5-HYDROXYDANTROLENE
• 5-HYDROXY-1-[[[5-(4-NITROPHENYL)-2-FURANYL]METHYLENE]AMINO]

5-Hydroxy Dantrolene

Controlled Product

CAS: 52130-25-3

Formula: C₁₄H₁₀N₄O₆

Color and Shape: Yellow

Molecular weight: 330.25

Ref: TR-H825175

5-Hydroxy Dantrolene Sulfate Sodium Salt

Controlled Product

CAS: 52130-25-3

Formula: C₁₄H₉N₄O₉S·Na

Color and Shape: Neat

Molecular weight: 432.297

Ref: TR-H825615

5-Hydroxy dantrolene

CAS: 52130-25-3

Dantrolene is a drug that has been used for the treatment of muscle spasms, including those caused by tetanus, dystonia, and other neuromuscular diseases. Dantrolene binds to the ryanodine receptor in the sarcoplasmic reticulum of skeletal muscle cells and blocks calcium release from these stores, leading to relaxation of contracted muscles. It also inhibits the uptake of organic anions through P-450 isozymes in the liver and brain. Dantrolene has potent inhibitory activity on p-450 isozymes and gastrocnemius muscle contractility. This drug also has been shown to be effective as a pharmacologic agent for treating renal proximal tubule cells in vitro. Dantrolene can be administered orally or intravenously and its terminal half-life is approximately 2 hours. The drug has a volume of distribution of 1 L/kg following intravenous administration and exhibits no significant binding to plasma proteins.

Formula: C₁₄H₁₀N₄O₆

Purity: Min. 95%

Molecular weight: 330.25 g/mol

Ref: 3D-FH23964

5-Hydroxy Dantrolene

CAS: 52130-25-3

Formula: C₁₄H₁₀N₄O₆

Molecular weight: 330.3

Ref: ST-EA-CP-D103005