CAS 521984-48-5

6,7-dimethoxy-2-[(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-enoyl]-1,2,3,4-tetrahydroisoquinoline hydrochloride

Description:

6,7-Dimethoxy-2-[(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-enoyl]-1,2,3,4-tetrahydroisoquinoline hydrochloride is a complex organic compound characterized by its unique structural features, including a tetrahydroisoquinoline core and multiple functional groups. The presence of methoxy groups at the 6 and 7 positions enhances its solubility and may influence its biological activity. The compound also contains a pyrrolo[2,3-b]pyridine moiety, which is known for its potential pharmacological properties. As a hydrochloride salt, it is likely to exhibit improved stability and solubility in aqueous environments, making it suitable for various applications, including medicinal chemistry. The compound's intricate structure suggests potential interactions with biological targets, which may be of interest in drug development. However, specific biological activities, toxicity, and pharmacokinetic properties would require further investigation through experimental studies. Overall, this compound represents a significant area of interest in the field of organic and medicinal chemistry.

Formula: C₂₈H₂₈ClN₃O₃

InChI: InChI=1/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H/b12-11+;

SIS3 Hydrochloride

CAS: 521984-48-5

Formula: C₂₈H₂₈ClN₃O₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 489.9932

Ref: IN-DA00DBB8

(E)-1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one hydrochloride

CAS: 521984-48-5

(E)-1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one hydrochloride

Purity: 98%

Molecular weight: 489.99g/mol

Ref: 54-OR1022965

SIS3

CAS: 521984-48-5

Formula: C₂₈H₂₇N₃O₃·HCl

Molecular weight: 489.99

Ref: 7W-GL6005

(E)-SIS3

CAS: 521984-48-5

(E)-SIS3

Purity: ≥95%

Molecular weight: 489.99g/mol

Ref: 54-BUP12057

SIS 3 Hydrochloride

CAS: 521984-48-5

Formula: C₂₈H₂₇N₃O₃·HCl

Purity: >98.0%(HPLC)

Color and Shape: Light yellow to Brown powder to crystal

Molecular weight: 490.00

Ref: 3B-I1110

(E)-SIS3

CAS: 521984-48-5

(E)-SIS3 (SIS3) is a Smad3 inhibitor (IC50=3 μM) selective.inhibits the differentiation of fibroblasts into myofibroblasts via TGF-β1. High-Quality, Low-Cost!

Formula: C₂₈H₂₇N₃O₃·HCl

Purity: 95.64% - 98%

Color and Shape: Solid

Molecular weight: 489.99

Ref: TM-T3636

1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline Monohydrochloride

Controlled Product

CAS: 521984-48-5

Applications 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline Monohydrochloride is a potent and selective Smad3 inhibitor that attenuates transforming growth factor (TGF)-β1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4 (1). It also inhibits TGF-β1-induced myofibroblast differentiation of dermal fibroblasts and TGF-β2-induced endothelial cell differentiation in iPSCs (1,2).
References (1) Jinnin, M., et al. Mol.Pharmacol. 69 597 (2006). (2) Di Bernardini, M., et al.: J.Biol.Chem. 289 3383 (2014).

Formula: C₂₈H₂₇N₃O₃·HCl

Color and Shape: Neat

Molecular weight: 489.993

Ref: TR-T292310

SIS3

CAS: 521984-48-5

SIS3 is a selective Smad3 inhibitor, which is a small-molecule compound derived through synthetic chemical methods. It is designed to specifically inhibit the phosphorylation and activity of the Smad3 protein, a critical transcription factor involved in the transforming growth factor-beta (TGF-β) signaling pathway. Smad3 is implicated in various cellular processes, including proliferation, differentiation, and apoptosis.

Formula: C₂₈H₂₇N₃O₃·HCl

Purity: Min. 95%

Molecular weight: 489.99 g/mol

Ref: 3D-WVA98448