CAS 522-17-8

Deguelin

Description:

Deguelin is a naturally occurring compound classified as a flavonoid, specifically a member of the rotenoid family. It is primarily derived from various plant species, particularly those in the Fabaceae family. Deguelin exhibits a range of biological activities, including anti-inflammatory, anti-cancer, and anti-diabetic properties, making it of interest in pharmacological research. The compound has been shown to inhibit certain enzymes and pathways involved in cancer cell proliferation and survival. Chemically, deguelin is characterized by its complex structure, which includes multiple rings and functional groups that contribute to its reactivity and biological activity. It is typically found in a solid form at room temperature and is soluble in organic solvents. Due to its potential therapeutic benefits, deguelin has garnered attention in the fields of medicinal chemistry and natural product research, although further studies are needed to fully understand its mechanisms of action and potential applications in clinical settings.

Formula: C₂₃H₂₂O₆

InChI: InChI=1/C23H22O6/c1-23(2)8-7-12-15(29-23)6-5-13-21(24)20-14-9-17(25-3)18(26-4)10-16(14)27-11-19(20)28-22(12)13/h5-10,19-20H,11H2,1-4H3/t19-,20+/m1/s1

InChI key: InChIKey=ORDAZKGHSNRHTD-UXHICEINSA-N

SMILES: O=C1C=2C(=C3C(=CC2)OC(C)(C)C=C3)O[C@]4([C@@]1(C=5C(OC4)=CC(OC)=C(OC)C5)[H])[H]

Synonyms:

• (-)-cis-Deguelin
• (7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6′,5′-e]pyran-7(7aH)-one
• (7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-on
• (7aS-cis)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one
• 3H-Bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS,13aS)-
• 3H-Bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS-cis)-
• 3H-Bis[1]benzopyrano[3,4-b:6′,5′-e]pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-
• 3H-Bis[1]benzopyrano[3,4-b:6′,5′-e]pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS,13aS)-
• 3H-Bis[1]benzopyrano[3,4-b:6′,5′-e]pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS-cis)-
• 3H-[1]Benzopyrano[3,4-b]pyrano[2,3-h][1]benzopyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS,13aS)-
• 3H-pyrano[2',3':7,8][1]benzopyrano[2,3-c][1]benzopyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS,13aS)-
• Deguelin
• (7aS,13aS)-9,10-Diméthoxy-3,3-diméthyl-13,13a-dihydro-3H-chroméno[3,4-b]pyrano[2,3-h]chromén-7(7aH)-one
• (7aS)-3,3-Dimethyl-9,10-dimethoxy-7,7aα,13,13aα-tetrahydro-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7-one
• (7AS,13AS)-13,13A-DIHYDRO-9,10-DIMETHOXY-3,3-DIMETHYL-3H-BIS[1]BENZOPYRANO[3,4-B:6',5'-E]PYRAN-7(7AH)-ONE
• (7as-cis)-oxy-
• 3h-bis(1)benzopyrano(3,4-b:6’,5’-e)pyran-7(7ah)-one,13,13a-dihydro-9,10-dimeth
• (7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-pyrano[2,3-c:6,5-f']dichromen-7(7aH)-one
• 3,3-Dimethyl-9,10-dimethoxy-7,7aα,13,13aα-tetrahydro-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7-one
• (-)-DEGUELIN;(-)-CIS-DEGUELIN
• Deguelin (6CI)
• 12a-DEOXYTEPHROSIN
• (7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-(3H)-bis[1]benzopyrano[3.4-b.6'.5'-e]pyran-7(7aH)-one

Deguelin

CAS: 522-17-8

Formula: C₂₃H₂₂O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 394.4172

Ref: IN-DA00D7ZC

Deguelin

CAS: 522-17-8

Deguelin

Purity: ≥95%

Molecular weight: 394.42g/mol

Ref: 54-BUP10439

(-)-Deguelin

CAS: 522-17-8

Formula: C₂₃H₂₂O₆

Purity: ≥ 98.0%

Color and Shape: White to beige powder

Molecular weight: 394.42

Ref: 7W-GL4230

(7As,13As)-9,10-Dimethoxy-3,3-Dimethyl-13,13A-Dihydro-3H-Pyrano[2,3-C:6,5-F']Dichromen-7(7Ah)-One

CAS: 522-17-8

(7As,13As)-9,10-Dimethoxy-3,3-Dimethyl-13,13A-Dihydro-3H-Pyrano[2,3-C:6,5-F']Dichromen-7(7Ah)-One

Purity: 98%

Molecular weight: 394.42g/mol

Ref: 54-OR1026149

Deguelin

CAS: 522-17-8

Formula: C₂₃H₂₂O₆

Purity: 95%~99%

Color and Shape: Powder

Molecular weight: 394.423

Ref: BP-BP3110

Deguelin

CAS: 522-17-8

Deguelin ((-)-Deguelin) is a PI3K/AKT Inhibitor, which is a natural product isolated from plants in the Mundulea sericea family.

Formula: C₂₃H₂₂O₆

Purity: 96.39% - 99.29%

Color and Shape: Solid

Molecular weight: 394.42

Ref: TM-T6817

Deguelin

CAS: 522-17-8

Oxygen-heterocyclic compound

Formula: C₂₃H₂₂O₆

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 394.42

Ref: 5G-22641

Deguelin

Controlled Product

CAS: 522-17-8

Applications Deguelin exhibits potent apoptotic and antiangiogenic activities in a variety of transformed cells and cancer cells. Deguelin also exhibits potent tumor suppressive effects in xenograft tumor models for many human cancers.
References Chang, D.J.. et al.: J. Med. Chem., 55, 10863 (2012);

Formula: C₂₃H₂₂O₆

Color and Shape: Light Yellow

Molecular weight: 394.42

Ref: TR-D229205

(-)-Deguelin

CAS: 522-17-8

Formula: C₂₃H₂₂O₆

Purity: >95.0%(HPLC)

Color and Shape: White to Yellow to Green powder to crystal

Molecular weight: 394.42

Ref: 3B-D5646

Deguelin

CAS: 522-17-8

Deguelin is a rotenoid, which is a naturally occurring compound derived primarily from the roots of plants in the Leguminosae family, such as Mundulea sericea and Derris species. It functions as a potent inhibitor of mitochondrial complex I, interfering with cellular respiration by blocking electron transport within the mitochondrial electron transport chain. This action leads to the inhibition of ATP production, which is essential for cellular energy.

Formula: C₂₃H₂₂O₆

Purity: Min. 95%

Molecular weight: 394.42 g/mol

Ref: 3D-FD65404

DEGUELIN

CAS: 522-17-8

Purity: 98%

Molecular weight: 394.4230042

Ref: 10-F814502