CAS 52205-73-9

Estramustine phosphate sodium

Description:

Estramustine phosphate sodium is a synthetic compound that combines the properties of an estrogen and a nitrogen mustard, making it a unique chemotherapeutic agent. It is primarily used in the treatment of prostate cancer. The compound functions as an antineoplastic agent, exerting its effects by interfering with DNA synthesis and cell division. Estramustine phosphate sodium is typically administered orally and is known for its ability to inhibit the growth of cancer cells while also possessing some estrogenic activity, which can lead to side effects related to hormonal changes. The sodium salt form enhances its solubility and bioavailability. In terms of its chemical structure, it features a phosphate group that contributes to its pharmacological properties. As with many chemotherapeutic agents, monitoring for potential side effects, including gastrointestinal disturbances and effects on blood counts, is essential during treatment. Overall, Estramustine phosphate sodium represents a significant option in the therapeutic arsenal against prostate cancer, particularly in cases resistant to other treatments.

Formula: C₂₃H₃₂Cl₂NO₆P·2Na

InChI: InChI=1S/C23H32Cl2NO6P.2Na/c1-23-9-8-18-17-5-3-16(31-22(27)26(12-10-24)13-11-25)14-15(17)2-4-19(18)20(23)6-7-21(23)32-33(28,29)30;;/h3,5,14,18-21H,2,4,6-13H2,1H3,(H2,28,29,30);;/t18-,19-,20+,21+,23+;;/m1../s1

InChI key: InChIKey=IVXNINGCQWCJJG-VVSKJQCTSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(OC(N(CCCl)CCCl)=O)=CC4)(CC1)[H])[H])(CC[C@@H]2OP(=O)(O)O)[H].[Na]

Synonyms:

• (17-Beta)-Estra-1,3,5(10)-Triene-3,17-Diol 3-(Bis(2-Chloroethyl)Carbamate) 17-(Dihydrogenphosphate) Disodium Salt
• Disodium (17Beta)-3-{[Bis(2-Chloroethyl)Carbamoyl]Oxy}Estra-1,3,5(10)-Trien-17-Yl Phosphate
• Emcyt
• Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), sodium salt (1:2)
• Estra-1,3,5(10)-triene-3,17-diol (17β)-, 3-[bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt
• Estracyt
• Estramustine Phosphate Sodium
• Estramustine disodium phosphate
• Estramustine phosphate disodium
• Estramustine phosphate disodium salt
• Ro 21-8837/001

Estramustine phosphate sodium

CAS: 52205-73-9

Formula: C₂₃H₃₀Cl₂NNa₂O₆P

Purity: %

Color and Shape: Solid

Molecular weight: 564.3467

Ref: IN-DA00I9C8

Estramustine phosphate sodium

CAS: 52205-73-9

Estramustine phosphate sodium

Purity: ≥95%

Molecular weight: 564.35g/mol

Ref: 54-BUP11213

Estramustine Phosphate Sodium

CAS: 52205-73-9

Estramustine Phosphate Sodium

Purity: 99%

Molecular weight: 564.35g/mol

Ref: 54-OR1025482

Estramustine phosphate sodium

CAS: 52205-73-9

Estramustine phosphate sodium (Ro 21-8837/001) is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.

Formula: C₂₃H₃₀Cl₂NNa₂O₆P

Purity: 96.44% - 99.54%

Color and Shape: Solid

Molecular weight: 564.35

Ref: TM-T4451

Estramustine sodium phosphate

CAS: 52205-73-9

Estramustine is a cytotoxic agent that inhibits the growth of cancer cells by interfering with intracellular targets. It is classified as an alkylating agent, which means it damages DNA and RNA by binding to them. Estramustine can be used in chemotherapy for the treatment of various types of cancers, including prostate cancer. This drug has minimal toxicity and long-term toxicity effects on the prostate gland, which limits its use in treating prostate cancer. Estramustine phosphate also inhibits a protein that helps maintain cellular calcium levels and can be used as an anti-inflammatory agent.

Formula: C₂₃H₃₂Cl₂NO₆P•Na₂

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 566.36 g/mol

Ref: 3D-FE15526

Estramustine Disodium Phosphate (~85%)

Controlled Product

CAS: 52205-73-9

Stability Unstable in Solution
Applications Estramustine sodium phosphate is binds estradiol receptors irreversibly.
References Aurilio, G. et al.: Int. J. Clin. Oncol., 20, 90 (2015);

Formula: C₂₃H₃₀Cl₂NNa₂O₆P

Purity: ~85%

Color and Shape: Neat

Molecular weight: 564.35

Ref: TR-E888983