CAS 52212-02-9

Pipecuronium bromide

Description:

Pipecuronium bromide is a neuromuscular blocking agent primarily used in anesthesia to facilitate muscle relaxation during surgical procedures. It is classified as a non-depolarizing neuromuscular blocker, which means it works by competitively inhibiting the action of acetylcholine at the neuromuscular junction, preventing muscle contraction. This compound is characterized by its long duration of action, making it suitable for prolonged surgeries. Pipecuronium bromide is typically administered intravenously and is known for its minimal cardiovascular effects, which is advantageous in patients with cardiovascular concerns. The substance is a quaternary ammonium compound, and its chemical structure includes a piperidine ring, contributing to its pharmacological properties. It is important to monitor patients for potential side effects, such as residual neuromuscular blockade, and to ensure proper dosing to avoid complications. As with other neuromuscular blockers, the use of pipecuronium bromide requires careful consideration of patient-specific factors, including renal function, as it is primarily eliminated through the kidneys.

Formula: C₃₅H₆₂N₄O₄·2Br

InChI: InChI=1S/C35H62N4O4.2BrH/c1-24(40)42-32-21-26-9-10-27-28(35(26,4)23-31(32)37-15-19-39(7,8)20-16-37)11-12-34(3)29(27)22-30(33(34)43-25(2)41)36-13-17-38(5,6)18-14-36;;/h26-33H,9-23H2,1-8H3;2*1H/q+2;;/p-2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-;;/m0../s1

InChI key: InChIKey=TXWBOBJCRVVBJF-YTGGZNJNSA-L

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@@](CC3)(C[C@H](OC(C)=O)[C@H](C4)N5CC[N+](C)(C)CC5)[H])(CC1)[H])[H])(C[C@@H]([C@@H]2OC(C)=O)N6CC[N+](C)(C)CC6)[H].[Br-]

Synonyms:

• (2Beta,3Alpha,5Alpha,16Beta,17Beta)-3,17-Bis(Acetyloxy)-2,16-Bis(4,4-Dimethylpiperazin-4-Ium-1-Yl)Androstane Dibromide
• (2Beta,9Xi,14Xi,16Beta,17Beta)-3,17-Bis(Acetyloxy)-2,16-Bis(4,4-Dimethylpiperazin-4-Ium-1-Yl)Androstane Dibromide
• (2beta,3alpha,5alpha,16beta,17beta)-3,17-Diacetoxy-2,16-bis(4,4-dimethylpiperazin-4-ium-1-yl)androstane dibromide
• 257-740-4
• 4,4'-((2Beta,3Alpha,5Alpha,16Beta,17Beta)-3,17-Bis(Acetyloxy)Androstane-2,16-Diyl)Bis(1,1-Dimethyl-Piperazinium) Dibromide
• 4,4'-[(2b,3a,5a,16b,17b)-3,17-Bis(acetyloxy)androstane-2,16-diyl]bis(1,1-dimethylpiperazinium) Dibromide
• Androstane-3,17-Diol, 2,16-Bis(4,4-Dimethyl-1-Piperaziniumyl)-, Bromide, Diacetate (Ester), (2Beta,3Alpha,5Alpha,16Beta,17Beta)- (1:2)
• Arduan
• Pipecurium bromide
• Piperazinium, 4,4′-[(2β,3α,5α,16β,17β)-3,17-bis(acetyloxy)androstane-2,16-diyl]bis[1,1-dimethyl-, bromide (1:2)
• Piperazinium, 4,4′-[(2β,3α,5α,16β,17β)-3,17-bis(acetyloxy)androstane-2,16-diyl]bis[1,1-dimethyl-, dibromide
• Rgh 1106

Pipecuronium bromide

CAS: 52212-02-9

Pipecuronium bromide

Purity: ≥98%

Molecular weight: 762.7g/mol

Ref: 54-BUP01553

Pipecuronium Bromide

CAS: 52212-02-9

Formula: C₃₅H₆₂N₄O₄·2Br

Color and Shape: White To Off-White Solid

Molecular weight: 602.90 2*79.90

Ref: 4Z-P-388001

Pipecuronium bromide

CAS: 52212-02-9

Formula: C₃₅H₆₂Br₂N₄O₄

Molecular weight: 762.70

Ref: 7W-GP0450

Pipecuronium Bromide

CAS: 52212-02-9

Applications Pipecuronium Bromide is a muscle relaxant and an anaesthesia used in patients undergoing coronary artery bypass graft surgery.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Stanley, J.C., et al.: Eur. J. Anaesthesiol., 8, 151 (1991); Zappi, L., et al.: Anesthesiol., 91, 1616 (1999);

Formula: C₃₅H₆₂N₄O₄·2Br

Color and Shape: Neat

Molecular weight: 762.70

Ref: TR-P479780

Pipecuronium bromide

CAS: 52212-02-9

Pipecuronium bromide (RGH-1106) is an nAChR antagonist that also acts as a non-depolarising steroidal neuromuscular blocker that causes muscle relaxation.

Formula: C₃₅H₆₂Br₂N₄O₄

Purity: >99.99%

Color and Shape: Powder

Molecular weight: 762.7

Ref: TM-T12481

Pipecurium bromide

CAS: 52212-02-9

Pipecurium bromide is a neuromuscular blocking agent that inhibits the enzyme acetylcholinesterase. It is used as a diagnostic aid in clinical practice and for intubation of patients with respiratory failure due to paralysis of the respiratory muscles. Pipecurium bromide has been shown to reduce serum aminotransferase levels and cardiac arrhythmias when given intravenously. This drug also has a low toxicity profile and does not affect body mass index or kinetic energy. Pipecurium bromide is chemically stable in nitrous oxide, which can be used for administration through an endotracheal tube.

Formula: C₃₅H₆₂N₄O₄·2Br

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 762.7 g/mol

Ref: 3D-FP37183