CAS 52232-67-4

Teriparatide

Description:

Teriparatide is a synthetic form of parathyroid hormone (PTH) used primarily in the treatment of osteoporosis. It is characterized by its ability to stimulate bone formation, making it distinct from other osteoporosis treatments that primarily focus on inhibiting bone resorption. Teriparatide is administered via subcutaneous injection and is typically prescribed for patients at high risk of fractures. The substance is composed of the first 34 amino acids of human PTH, which are crucial for its biological activity. Its mechanism of action involves binding to PTH receptors on osteoblasts, promoting bone growth and increasing calcium absorption in the intestines and kidneys. Teriparatide has a relatively short half-life, necessitating daily administration for optimal therapeutic effects. Common side effects may include nausea, dizziness, and leg cramps. Due to its anabolic effects on bone, teriparatide is often considered for use in postmenopausal women and men with osteoporosis who have a history of fractures or significant bone loss.

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂・C₂H₄O<

InChI: InChI=1/C181H291N55O51S2/c1-21-96(18)146(236-160(267)114(48-53-141(250)251)212-174(281)132(84-239)232-177(284)143(93(12)13)233-147(254)103(185)82-237)178(285)216-111(45-50-134(187)241)155(262)219-119(65-90(6)7)163(270)213-116(55-62-289-20)158(265)224-124(71-100-79-196-86-203-100)167(274)226-126(73-135(188)242)169(276)217-117(63-88(2)3)148(255)201-81-138(245)205-105(39-27-30-56-182)149(256)223-123(70-99-78-195-85-202-99)166(273)221-121(67-92(10)11)164(271)225-128(75-137(190)244)171(278)231-131(83-238)173(280)214-115(54-61-288-19)157(264)210-112(46-51-139(246)247)153(260)208-109(43-34-60-199-181(193)194)159(266)234-144(94(14)15)175(282)215-113(47-52-140(248)249)156(263)222-122(69-98-77-200-104-38-26-25-37-102(98)104)165(272)220-120(66-91(8)9)161(268)209-108(42-33-59-198-180(191)192)151(258)206-106(40-28-31-57-183)150(257)207-107(41-29-32-58-184)152(259)218-118(64-89(4)5)162(269)211-110(44-49-133(186)240)154(261)228-129(76-142(252)253)172(279)235-145(95(16)17)176(283)229-125(72-101-80-197-87-204-101)168(275)227-127(74-136(189)243)170(277)230-130(179(286)287)68-97-35-23-22-24-36-97/h22-26,35-38,77-80,85-96,103,105-132,143-146,200,237-239H,21,27-34,39-76,81-84,182-185H2,1-20H3,(H2,186,240)(H2,187,241)(H2,188,242)(H2,189,243)(H2,190,244)(H,195,202)(H,196,203)(H,197,204)(H,201,255)(H,205,245)(H,206,258)(H,207,257)(H,208,260)(H,209,268)(H,210,264)(H,211,269)(H,212,281)(H,213,270)(H,214,280)(H,215,282)(H,216,285)(H,217,276)(H,218,259)(H,219,262)(H,220,272)(H,221,273)(H,222,263)(H,223,256)(H,224,265)(H,225,271)(H,226,274)(H,227,275)(H,228,261)(H,229,283)(H,230,277)(H,231,278)(H,232,284)(H,233,254)(H,234,266)(H,235,279)(H,236,267)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,286,287)(H4,191,192,198)(H4,193,194,199)

SMILES: CCC(C)C(C(=NC(CCC(=N)O)C(=NC(CC(C)C)C(=NC(CCSC)C(=NC(Cc1cnc[nH]1)C(=NC(CC(=N)O)C(=NC(CC(C)C)C(=NCC(=NC(CCCCN)C(=NC(Cc1cnc[nH]1)C(=NC(CC(C)C)C(=NC(CC(=N)O)C(=NC(CO)C(=NC(CCSC)C(=NC(CCC(=O)O)C(=NC(CCCNC(=N)N)C(=NC(C(C)C)C(=NC(CCC(=O)O)C(=NC(Cc1c[nH]c2ccccc12)C(=NC(CC(C)C)C(=NC(CCCNC(=N)N)C(=NC(CCCCN)C(=NC(CCCCN)C(=NC(CC(C)C)C(=NC(CCC(=N)O)C(=NC(CC(=O)O)C(=NC(C(C)C)C(=NC(Cc1cnc[nH]1)C(=NC(CC(=N)O)C(=NC(Cc1ccccc1)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C(C(CCC(=O)O)N=C(C(CO)N=C(C(C(C)C)N=C(C(CO)N)O)O)O)O

Synonyms:

• Teriparatide Acetate
• Forteo
• L-Phenylalanine, L-seryl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparaginyl-, acetate (salt) hydrate
• L-Seryl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparaginyl-L-phenylalanine acetate (salt) hydrate
• Parathar
• Parathar acetate
• L-Phenylalanine, L-seryl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparaginyl-, acetate (salt)

Parathyroid Hormone (1-34), human

CAS: 52232-67-4

Parathyroid Hormone (1-34), human

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Molecular weight: 4117.7

Ref: 02-J66180

pTH (1-34) (human)

CAS: 52232-67-4

Teriparatide, which consists of the N-terminal 34 amino acid residues of parathyroid hormone, shows the same potency and pharmacological profile as the native hormone. Administration of teriparatide stimulates bone formation and increases the bone mineral density (BMD).

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Purity: 99.1%

Color and Shape: White

Molecular weight: 4117.77

Ref: 01-4011474

pTH (1-34) (human)

CAS: 52232-67-4

Intermittent administration of teriparatide stimulates bone formation by increasing the number of osteoblasts. Agonist of the parathyroid hormone receptor PTH1.

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Purity: 96.3%

Color and Shape: White

Molecular weight: 4117.77

Ref: 01-4095855

TERIPARATIDE FOR SYSTEM SUITABILITY CRS

CAS: 52232-67-4

TERIPARATIDE FOR SYSTEM SUITABILITY CRS

Formula: C₁₃H₁₄ClNO

Molecular weight: 235.7094

Ref: 41-Y0001895

TERIPARATIDE CRS

CAS: 52232-67-4

TERIPARATIDE CRS

Formula: C₁₃H₁₄ClNO

Color and Shape: Added Added

Molecular weight: 235.7094

Ref: 41-Y0001916

Teriparatide

CAS: 52232-67-4

Polypeptide, protein and glycoprotein hormones, their derivatives and structural analogues, nesoi

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Color and Shape: White Off-White Powder

Molecular weight: 4115.13094

Ref: 45-1643962

Teriparatide acetate

CAS: 52232-67-4

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 4117.7151

Ref: IN-DA01CC00

Teriparatide Tetraacetate

CAS: 52232-67-4

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂·4C₂H₄O₂

Molecular weight: 4117.77 4*60.05

Ref: 4Z-PT-255001

Teriparatide

CAS: 52232-67-4

Teriparatide is an agonist of PHT(IC50 of 2 nM in HEK293 cells).

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 4117.72

Ref: TM-T13128

Teriparatide acetate

CAS: 52232-67-4

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Molecular weight: 4117.77

Ref: 7W-GX8046

pTH (1-34) (human)

CAS: 52232-67-4

pTH (1-34) (human)

Color and Shape: Solid

Ref: 54-BIBA1023

Parathyroid Hormone Fragment (1-34)- 24,d3 TFA Salt

Controlled Product

CAS: 52232-67-4

Stability Hygroscopic
Applications Parathyroid Hormone Fragment (1-34)-24,d3,TFA Salt is the labeled (on Leucine-d3, position 24) analogue of Parathyroid Hormone Fragment (1-34) (P192200), which is a fragment of human parathyroid hormone (hPTH) peptide sequence containing the 34 N-terminal residues of hPTH. This fragment was also found to be an agonist at PTH1 and PTH2 receptors.
References Niall, et al.: Proc. Natl. Acad. Sci., 71, 384 (1974); Dobnig,T., et al.: Endocrinol., 138, 4607 (1997); Manabe. et al.: Bone., 40, 1475 (2007);

Formula: C₁₈₁D₃H₂₈₈N₅₅O₅₁S₂·xC₂O₂HF₃

Color and Shape: Neat

Molecular weight: 4234.8

Ref: TR-P192202

Parathyroid Hormone Fragment (1-34)

Controlled Product

CAS: 52232-67-4

Applications A fragment of human parathyroid hormone (hPTH) peptide sequence containing the 34 N-terminal residues of hPTH. This fragment was also found to be an agonist at PTH1 and PTH2 receptors.
References Niall, et al.: Proc. Natl. Acad. Sci., 71, 384 (1974); Dobnig,T., et al.: Endocrinol., 138, 4607 (1997); Manabe. et al.: Bone., 40, 1475 (2007);

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Color and Shape: Neat

Molecular weight: 4117.72

Ref: TR-P192200

Teriparatide-d10

Controlled Product

CAS: 52232-67-4

Formula: C₁₈₁D₁₀H₂₈₁N₅₅O₅₁S₂

Color and Shape: Neat

Molecular weight: 4127.72

Ref: TR-T512227

Parathyroid Hormone (Human, 1-34)

CAS: 52232-67-4

This product which is available as a 0.5mg vial is amino acids 1-34 of the 84 amino acid parathyroid hormone (PTH) and can be used as an adenylate cyclase and bone growth stimulating peptide. It is possible that in can be used in research in the treatments of some types of osteoporosis.
PTH is a peptide hormone that is secreted from the parathyroid gland in the event of abnormal serum calcium levels and it ultimately regulates calcium and phosphate levels in the body. The PTH exerts its activity through binding to the G-protein coupled receptor type 1 PTH receptor, which activates adenylate cyclase or phospholipase C thus activating pathways involved in the mediation of bone resorption and bone formation. This product is suitable for life science applications.

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Purity: Min. 95%

Molecular weight: 4,117.7 g/mol

Ref: 3D-PTH-4068-V

TeripaRatide Acetate

CAS: 52232-67-4

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Molecular weight: 4,117.8 g/mol

Ref: 3D-PP50195

Parathyroid Hormone (Human, 1-34)

CAS: 52232-67-4

This product which is available as a 0.1mg vial is amino acids 1-34 of the 84 amino acid parathyroid hormone (PTH) and can be used as an adenylate cyclase and bone growth stimulating peptide. It is also an effective anabolic agent used in the treatment of some forms of Osteoporosis.
PTH is a peptide hormone that is secreted from the parathyroid gland in the event of abnormal serum calcium levels and it ultimately regulates calcium and phosphate levels in the body. The PTH exerts its activity through binding to the G-protein coupled receptor type 1 PTH receptor, which activates adenylate cyclase or phospholipase C thus activating pathways involved in the mediation of bone resorption and bone formation. This product is suitable for life science applications.

Formula: C₁₈₁H₂₉₁N₅₅O₅₁S₂

Purity: Min. 95%

Molecular weight: 4,117.7 g/mol

Ref: 3D-PTH-4068-S