CAS 52299-14-6

Succinyl-L-alanyl-L-alanyl-L-alanine p-nitroanilide

Description:

Succinyl-L-alanyl-L-alanyl-L-alanine p-nitroanilide is a synthetic peptide substrate commonly used in biochemical assays, particularly for the detection of proteolytic enzymes such as serine proteases. This compound features a succinyl group, which enhances its solubility and stability, and a p-nitroanilide moiety that serves as a chromogenic indicator. Upon enzymatic cleavage, the release of p-nitroaniline results in a measurable color change, allowing for quantification of enzyme activity. The structure consists of a sequence of amino acids, specifically L-alanine residues, contributing to its specificity and interaction with target enzymes. The compound is typically soluble in aqueous solutions and exhibits stability under standard laboratory conditions. Its use in research and diagnostic applications highlights its importance in understanding enzyme kinetics and protein interactions. As with many peptide substrates, care should be taken regarding storage conditions and handling to maintain its integrity and reactivity.

Formula: C₁₉H₂₅N₅O₈

InChI: InChI=1S/C19H25N5O8/c1-10(20-15(25)8-9-16(26)27)17(28)21-11(2)18(29)22-12(3)19(30)23-13-4-6-14(7-5-13)24(31)32/h4-7,10-12H,8-9H2,1-3H3,(H,20,25)(H,21,28)(H,22,29)(H,23,30)(H,26,27)/t10-,11-,12-/m0/s1

InChI key: InChIKey=GVUGADOWXGKRAE-SRVKXCTJSA-N

SMILES: N(C([C@@H](NC([C@@H](NC([C@@H](NC(CCC(O)=O)=O)C)=O)C)=O)C)=O)C1=CC=C(N(=O)=O)C=C1

Synonyms:

• 3-Carboxypropionyl-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>L</smallcap>-alanyl-<smallcap>L</span>-alanine p-nitroanilide
• 43: PN: CN101457218 PAGE: 2 claimed protein
• <span class="text-smallcaps">L</smallcap>-Alaninamide, N-(3-carboxy-1-oxopropyl)-<smallcap>L</smallcap>-alanyl-<smallcap>L</span>-alanyl-N-(4-nitrophenyl)-
• Chromozym ELA
• N-(3-Carboxy-1-oxopropyl)-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>L</smallcap>-alanyl-N-(4-nitrophenyl)-<smallcap>L</span>-alaninamide
• N-(3-carboxypropanoyl)-L-alanyl-L-alanyl-N-(4-nitrophenyl)-L-alaninamide
• N-SUCCINYL-(L-ALA)3-p-NITROANILIDE **03-32-0009**
• N-Succinyl-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>L</smallcap>-alanyl-<smallcap>L</span>-alanine p-nitroanilide
• N-Succinyl-Ala-Ala-Ala-p-nitroanilide
• Suc-Ala-Ala-Ala-pNA
• Succinyl-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>L</smallcap>-alanyl-<smallcap>L</span>-alanine 4-nitroanilide
• Succinyl-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>L</smallcap>-alanyl-<smallcap>L</span>-alanine p-nitroanilide
• Succinyl-<span class="text-smallcaps">L</smallcap>-alanyl-<smallcap>L</smallcap>-alanyl-<smallcap>L</span>-alanyl p-nitroanilide
• Succinyl-<span class="text-smallcaps">L</span>-trialanine p-nitroanilide
• N-Succinyl-L-alanyl-L-alanyl-L-alanine p-nitroanilide
• 3-Carboxypropionyl-L-alanyl-L-alanyl-L-alanine p-nitroanilide
• L-Alaninamide, N-(3-carboxy-1-oxopropyl)-L-alanyl-L-alanyl-N-(4-nitrophenyl)-
• Succinyl-L-alanyl-L-alanyl-L-alanine p-nitroanilide

Suc-Ala-Ala-Ala-pNA

CAS: 52299-14-6

Suc-AAA-pNA, a readily soluble and sensitive substrate for human and rat neutrophil and porcine pancreatic elastases. The trialanine substrate is also hydrolyzed by proteinase K, subtilisins and thermitase as well as by astacin, a crayfish zinc-endopeptidase.

Formula: C₁₉H₂₅N₅O₈

Purity: > 99%

Color and Shape: Light Yellow

Molecular weight: 451.44

Ref: 01-4000902

SUC-ALA-ALA-ALA-PNA

CAS: 52299-14-6

Formula: C₁₉H₂₅N₅O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 451.4305

Ref: IN-DA00D8ZJ

Suc-AAA-pNA

CAS: 52299-14-6

Suc-AAA-pNA is a synthetic peptide substrate commonly used for protease activity assays and widely applied in biochemical experiments.

Formula: C₁₉H₂₅N₅O₈

Purity: 99.75%

Color and Shape: Solid

Molecular weight: 451.43

Ref: TM-T205938

N-Succinyl-Ala-Ala-Ala-p-Nitroanilide

CAS: 52299-14-6

N-Succinyl-Ala-Ala-Ala-p-Nitroanilide

Purity: 98%

Molecular weight: 451.43g/mol

Ref: 54-OR1014482

Chromozym ELA

CAS: 52299-14-6

Formula: C₁₉H₂₅N₅O₈

Molecular weight: 451.44

Ref: 4Z-A-248084

N-Succinyl-L-alanyl-L-alanyl-L-alanine 4-nitroanilide

CAS: 52299-14-6

N-Succinyl-L-alanyl-L-alanyl-L-alanine 4 nitroanilide is a synthetic substrate that has been shown to have proteolytic activity against dextran sulfate, collagen, and sephadex g-100. It also has insecticidal activity in that it inhibits the development of larvae of the insect Drosophila melanogaster. NSLAAALAALAAN can be used as a chemotactic agent for tissue culture cells. This synthetic substrate was also found to have antiinflammatory properties and may be useful in treating chronic bronchitis or other metabolic disorders.

Formula: C₁₉H₂₅N₅O₈

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 451.43 g/mol

Ref: 3D-FS46953

Suc-Ala-Ala-Ala-pNA

CAS: 52299-14-6

Suc-Ala-Ala-Ala-pNA is a protease inhibitor that is used in the treatment of metabolic disorders. It has been shown to have neurotrophic effects, which may be due to its ability to inhibit the activity of proteases, such as cathepsin B and proteinase 3. Suc-Ala-Ala-Ala-pNA has also been shown to have anti-inflammatory properties, which may be due to its ability to inhibit the activity of proinflammatory cytokines such as interleukin 1β, tumor necrosis factor α, and prostaglandin E2. Suc-Ala-Ala-Ala-pNA has long term efficacy in treating neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

Formula: C₁₉H₂₅N₅O₈

Purity: Min. 95%

Molecular weight: 451.43 g/mol

Ref: 3D-SAA-3071

Suc-Ala-Ala-Ala-pNA

Controlled Product

CAS: 52299-14-6

Formula: C₁₉H₂₅N₅O₈

Color and Shape: Neat

Molecular weight: 451.43

Ref: TR-S224165

Suc-Ala-Ala-Ala-pNA

CAS: 52299-14-6

Suc-Ala-Ala-Ala-pNA is a peptide that binds to the acetylcholine receptor and activates it. This peptide has been shown to have potential as a research tool for studying the pharmacology of acetylcholine receptors in vitro. It has also been used as an inhibitor of neuronal ion channels, such as potassium channels, that are involved in the transmission of nerve impulses. Suc-Ala-Ala-Ala-pNA is not suitable for use in humans because it would be broken down by proteases before it could reach its target, but this peptide has applications in cell biology and neuroscience.

Formula: C₁₉H₂₅N₅O₈

Purity: Min. 95%

Molecular weight: 451.43 g/mol

Ref: 3D-SAA-3071-V