CAS 523-87-5: Dimenhydrinate
Description:Dimenhydrinate is an antihistamine commonly used to prevent and treat nausea, vomiting, and dizziness caused by motion sickness. It is a combination of diphenhydramine, an antihistamine, and 8-chlorotheophylline, a stimulant that counteracts the sedative effects of diphenhydramine. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for various formulations, including tablets and oral solutions. Dimenhydrinate works by blocking the action of histamine at H1 receptors and has anticholinergic properties, which contribute to its effectiveness in alleviating symptoms associated with motion sickness. Its onset of action typically occurs within 30 minutes to an hour, with effects lasting several hours. While generally well-tolerated, potential side effects may include drowsiness, dry mouth, and dizziness. Caution is advised when using dimenhydrinate in conjunction with other central nervous system depressants or in individuals with certain medical conditions, such as glaucoma or prostate enlargement.
Formula:C17H21NO·C7H7ClN4O2
InChI:InChI=1S/C17H21NO.C7H7ClN4O2/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h3-12,17H,13-14H2,1-2H3;1-2H3,(H,9,10)
InChI key:InChIKey=NFLLKCVHYJRNRH-UHFFFAOYSA-N
SMILES:O=C1C=2NC(Cl)=NC2N(C(=O)N1C)C.O(CCN(C)C)C(C=1C=CC=CC1)C=2C=CC=CC2
- Synonyms:
- 1H-Purine-2,6-dione, 8-chloro-3,7-dihydro-1,3-dimethyl-, compd. with 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1)
- 1H-Purine-2,6-dione, 8-chloro-3,7-dihydro-1,3-dimethyl-, compound with 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1)
- 2-(Diphenylmethoxy)-N,N-dimethylethylamine 8-chlorotheophyllinate
- 2-(diphenylmethoxy)-N,N-dimethylethanaminium 8-chloro-1,3-dimethyl-2-oxo-2,3-dihydro-1H-purin-6-olate
- 8-Chloro-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione compd. with 2-(diphenylmethoxy)-N,N-dimethylethanamine(1:1)
- Amosyt
- Anautine
- Andramine
- Antemin
- Aviomarin
- See more synonyms
- Chloranautine
- Diamarin
- Dimate
- Dimenhidrinato
- Dimenhydrinat
- Dimigal
- Diphenhydramine 8-Chlorotheophyllinate
- Diphenhydrinate
- Dommanate
- Dramamin
- Dramamine
- Dramarin
- Dramin
- Dramina
- Dramocen
- Dramyl
- Dromyl
- Emedyl
- Emes
- Epha
- Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, compd. with 8-chloro-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione (1:1)
- Ethylamine, 2-(diphenylmethoxy)-N,N-dimethyl-, compd. with 8-chlorotheophylline (1:1)
- Faston
- Gravinol
- Gravinol (antiemetic)
- Gravol
- Menhydrinate
- Neo-Navigan
- Novamin
- Novamine
- Nsc 117855
- Permital
- Reidamine
- Reise-Engletten
- Removine
- Supremal
- Teodramin
- Theohydramine
- Theophylline, 8-chloro-, compd. with 2-(diphenylmethoxy)-N,N-dimethylethylamine (1:1)
- Travel-Gum
- Travelin
- Travelmin
- Vomex A
- Xamamina
- Dimenhydrinate
