CAS 523-87-5

Dimenhydrinate

Description:

Dimenhydrinate is an antihistamine commonly used to prevent and treat nausea, vomiting, and dizziness caused by motion sickness. It is a combination of diphenhydramine, an antihistamine, and 8-chlorotheophylline, a stimulant that counteracts the sedative effects of diphenhydramine. The substance appears as a white to off-white crystalline powder and is soluble in water, making it suitable for various formulations, including tablets and oral solutions. Dimenhydrinate works by blocking the action of histamine at H1 receptors and has anticholinergic properties, which contribute to its effectiveness in alleviating symptoms associated with motion sickness. Its onset of action typically occurs within 30 minutes to an hour, with effects lasting several hours. While generally well-tolerated, potential side effects may include drowsiness, dry mouth, and dizziness. Caution is advised when using dimenhydrinate in conjunction with other central nervous system depressants or in individuals with certain medical conditions, such as glaucoma or prostate enlargement.

Formula: C₁₇H₂₁NO·C₇H₇ClN₄O₂

InChI: InChI=1S/C17H21NO.C7H7ClN4O2/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h3-12,17H,13-14H2,1-2H3;1-2H3,(H,9,10)

InChI key: InChIKey=NFLLKCVHYJRNRH-UHFFFAOYSA-N

SMILES: O=C1C2=C(N(C)C(=O)N1C)N=C(Cl)N2.C(OCCN(C)C)(C1=CC=CC=C1)C2=CC=CC=C2

Synonyms:

• 1H-Purine-2,6-dione, 8-chloro-3,7-dihydro-1,3-dimethyl-, compd. with 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1)
• 1H-Purine-2,6-dione, 8-chloro-3,7-dihydro-1,3-dimethyl-, compound with 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1)
• 2-(Diphenylmethoxy)-N,N-dimethylethylamine 8-chlorotheophyllinate
• 2-(diphenylmethoxy)-N,N-dimethylethanaminium 8-chloro-1,3-dimethyl-2-oxo-2,3-dihydro-1H-purin-6-olate
• 8-Chloro-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione compd. with 2-(diphenylmethoxy)-N,N-dimethylethanamine(1:1)
• Amosyt
• Anautine
• Andramine
• Antemin
• Aviomarin
• Chloranautine
• Diamarin
• Dimate
• Dimenhidrinato
• Dimenhydrinat
• Dimigal
• Diphenhydramine 8-Chlorotheophyllinate
• Diphenhydrinate
• Dommanate
• Dramamin
• Dramamine
• Dramarin
• Dramin
• Dramina
• Dramocen
• Dramyl
• Dromyl
• Emedyl
• Emes
• Epha
• Ethanamine, 2-(diphenylmethoxy)-N,N-dimethyl-, compd. with 8-chloro-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione (1:1)
• Ethylamine, 2-(diphenylmethoxy)-N,N-dimethyl-, compd. with 8-chlorotheophylline (1:1)
• Faston
• Gravinol
• Gravinol (antiemetic)
• Gravol
• Menhydrinate
• Neo-Navigan
• Novamin
• Novamine
• Nsc 117855
• Permital
• Reidamine
• Reise-Engletten
• Removine
• Supremal
• Teodramin
• Theohydramine
• Theophylline, 8-chloro-, compd. with 2-(diphenylmethoxy)-N,N-dimethylethylamine (1:1)
• Travel-Gum
• Travelin
• Travelmin
• Vomex A
• Xamamina

Dimenhydrinate

CAS: 523-87-5

Color and Shape: Neat

Ref: 61-FOR0599.00

Dimenhydrinate

CAS: 523-87-5

Formula: C₁₇H₂₁NOC₇H₇ClN₄O₂

Molecular weight: 255.4 : 214.6

Ref: ST-EA-CP-D52000

DIMENHYDRINATE CRS

CAS: 523-87-5

DIMENHYDRINATE CRS

Formula: C₂₄H₂₈ClN₅O₃

Color and Shape: Crystalline Powder. White. Whitish. Colourless Crystals. Powder.

Molecular weight: 469.9638

Ref: 41-D2000000

DIMENHYDRINATE FOR PEAK IDENTIFICATION CRS

CAS: 523-87-5

DIMENHYDRINATE FOR PEAK IDENTIFICATION CRS

Formula: C₂₄H₂₈ClN₅O₃

Color and Shape: Crystalline Powder. White. Whitish. Colourless. Powder.

Molecular weight: 469.9638

Ref: 41-Y0001103

Dimenhydrinate

CAS: 523-87-5

Theophylline and aminophylline (excluding fenetylline) and their derivatives, salts thereof, not elsewhere specified or included

Formula: C₁₇H₂₁NO·C₇H₇ClN₄O₂

Color and Shape: White Crystalline Powder

Molecular weight: 469.18807

Ref: 45-1206006

2-(Diphenylmethoxy)-N,N-dimethylethylamine 8-chlorotheophyllinate

CAS: 523-87-5

Formula: C₂₄H₂₈ClN₅O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 469.9638

Ref: IN-DA006UG1

Dimenhydrinate

CAS: 523-87-5

Dimenhydrinate (Vomex A) is an ethanolamine and histamine antagonist with anti-allergic activity.

Formula: C₂₄H₂₈ClN₅O₃

Purity: 99.57% - 99.77%

Color and Shape: Crystals Physical Description Crystalline White Powder (Ntp 1992)

Molecular weight: 469.96

Ref: TM-T0298

Dimenhydrinate, USP grade

CAS: 523-87-5

Formula: C₁₇H₂₁NO·C₇H₇ClN₄O₂

Color and Shape: White to off-white crystalline powder

Molecular weight: 469.96

Ref: 7W-GP8790

Dimenhydrinate

CAS: 523-87-5

Dimenhydrinate

Purity: ≥98%

Molecular weight: 469.96g/mol

Ref: 54-BUP17122

Dimenhydrinate

CAS: 523-87-5

Formula: C₁₇H₂₁NO·C₇H₇ClN₄O₂

Color and Shape: White to off-white powder

Molecular weight: 469.96

Ref: 7W-GP7751

Dimenhydrinate

CAS: 523-87-5

Dimenhydrinate

Purity: 99%

Molecular weight: 469.96g/mol

Ref: 54-OR1012911

Dimenhydrinate

Controlled Product

CAS: 523-87-5

Formula: C₁₇H₂₁NO·C₇H₇ClN₄O₂

Color and Shape: Neat

Molecular weight: 469.96

Ref: 86-MM0599.00

Dimenhydrinate

CAS: 523-87-5

Formula: C₁₇H₂₁NO·C₇H₇ClN₄O₂

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 469.97

Ref: 3B-D6336

Dimenhydrinate - Bio-X ™

Controlled Product

CAS: 523-87-5

Dimenhydrinate is a drug that was initially used as an antihistamine to treat symptoms of allergies such as watery eyes, sneezing and a runny nose, however it is now used for the treatment and prevention of nausea, vertigo and motion sickness. Dimenhydrinate is a combination of diphenhydramine and 8-chlorotheophylline. Its antiemetic properties are thought to be produced from diphenhydramine’s antagonism of H1 histamine receptors. Also, it is believed to have antimuscarinic effects that minimize disturbances to the body’s equilibrium.

Formula: C₂₄H₂₈ClN₅O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 469.96 g/mol

Ref: 3D-BD166163

Dimenhydrinate

Controlled Product

CAS: 523-87-5

Histamine receptor H1 antagonist; muscarinic receptor blocker

Formula: C₂₄H₂₈ClN₅O₃

Color and Shape: White Powder

Molecular weight: 469.96 g/mol

Ref: 3D-FD22159

Dimenhydrinate

Controlled Product

CAS: 523-87-5

Stability Hygroscopic
Applications An antihistamine with antiemetic properties used to prevent nausea and motion sicknes composed of two drugs 8-Chlorotheophylline (C411440) and Diphenhydramine (D486900).
References Sibel, K. et al.: Arzneim.-Forsch. , 52, 529 (2002); Pytel, J. et al.: Clin. Therap., 29, 84 (2007); Scholtz, A.W. et al.: Clin. Therap., 26, 866 (2004);

Formula: C₁₇H₂₁NO·C₇H₇ClN₄O₂

Color and Shape: Neat

Molecular weight: 469.96

Ref: TR-D460520