CAS 52329-60-9

Aminomebendazole

Description:

Aminomebendazole is a chemical compound that belongs to the class of benzimidazole derivatives, primarily known for its anthelmintic properties, which make it effective against parasitic infections. It is characterized by its ability to inhibit the polymerization of tubulin, thereby disrupting the cytoskeleton of the target organisms. This mechanism of action is similar to that of other benzimidazole compounds, leading to the paralysis and eventual death of the parasites. Aminomebendazole is typically administered in a solid form, and its solubility can vary depending on the pH of the environment. The compound is generally considered to have low toxicity in mammals, making it a suitable option for treating various helminthic infections. Additionally, it may exhibit some antifungal and antibacterial activities, although its primary use remains in the treatment of parasitic diseases. As with any pharmaceutical agent, proper dosage and administration are crucial to maximize efficacy while minimizing potential side effects.

Formula: C₁₄H₁₁N₃O

InChI: InChI=1S/C14H11N3O/c15-14-16-11-7-6-10(8-12(11)17-14)13(18)9-4-2-1-3-5-9/h1-8H,(H3,15,16,17)

InChI key: InChIKey=GPMHHSJZGVOEFS-UHFFFAOYSA-N

SMILES: C(=O)(C=1C=C2C(=CC1)N=C(N)N2)C3=CC=CC=C3

Synonyms:

• (2-Amino-1H-benzimidazol-5-yl)phenylmethanone
• (2-Amino-1H-benzimidazol-6-yl)phenylmethanone
• (2-Amino-3H-benzimidazol-5-yl)-phenylmethanone
• (2-amino-1H-benzimidazol-5-yl)(phenyl)methanone
• 2-Amino-5-benzoyl-1H-benzimidazole
• 2-Amino-5-benzoylbenzimidazole
• Aminomebendazole
• G 1029
• R 18986
• methanone, (2-amino-1H-benzimidazol-5-yl)phenyl-
• methanone, (2-amino-1H-benzimidazol-6-yl)phenyl-

Mebendazole EP Impurity A

CAS: 52329-60-9

Formula: C₁₄H₁₁N₃O

Color and Shape: Yellow Solid

Molecular weight: 237.26

Ref: 4Z-M-611

Mebendazole-amine 100 µg/mL in Acetonitrile

CAS: 52329-60-9

Formula: C₁₄H₁₁N₃O

Color and Shape: Single Solution

Molecular weight: 237.26

Ref: 04-A14798015AL-100

(2-Amino-1H-benzimidazol-5-yl)phenylmethanone

Controlled Product

CAS: 52329-60-9

Formula: C₁₄H₁₁N₃O

Color and Shape: Neat

Molecular weight: 237.26

Ref: 86-MM0882.01

Mebendazole-amine

CAS: 52329-60-9

Formula: C₁₄H₁₁N₃O

Color and Shape: Neat

Molecular weight: 237.26

Ref: 04-C14798015

2-Amino-5(6)-benzoylbenzimidazole

CAS: 52329-60-9

Impurity Mebendazole EP Impurity A
Applications The minor urinary metabolite of Mebendazole (M200500) in man. Mebendazole impurity.
References Leban, J., et al.: Bioorg. Med. Chem. Lett., 17, 5858 (2007),

Formula: C₁₄H₁₁N₃O

Color and Shape: Neat

Molecular weight: 237.26

Ref: TR-A593760

2-Amino-5(6)-benzoylbenzimidazole

CAS: 52329-60-9

2-Amino-5(6)-benzoylbenzimidazole is an antifilarial and anthelmintic drug that belongs to the benzimidazole class. It is used for the treatment of filarial infections in humans, including lymphatic filariasis, which is caused by worms transmitted by mosquitoes. 2-Amino-5(6)-benzoylbenzimidazole has low bioavailability due to its poor water solubility. The drug can be administered orally or topically and is metabolized in the liver. The metabolites are excreted in urine as glucuronides and sulfates.

Formula: C₁₄H₁₁N₃O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 237.26 g/mol

Ref: 3D-FA17593

Mebendazole EP Impurity A

CAS: 52329-60-9

Formula: C₁₄H₁₁N₃O

Molecular weight: 237.26

Ref: ST-EA-CP-M7001

Mebendazole-amine

CAS: 52329-60-9

R-18986 is a biochemical substance.

Formula: C₁₄H₁₁N₃O

Color and Shape: Solid

Molecular weight: 237.26

Ref: TM-T20528