CAS 52449-98-6

Tetrahydro-2-furancarbonyl chloride

Description:

Tetrahydro-2-furancarbonyl chloride, with the CAS number 52449-98-6, is an organic compound characterized by its furan ring structure that has been saturated and modified with a carbonyl chloride functional group. This compound typically appears as a colorless to pale yellow liquid and is known for its reactivity due to the presence of the carbonyl chloride moiety, which can participate in nucleophilic substitution reactions. It is soluble in organic solvents, making it useful in various synthetic applications, particularly in the preparation of other chemical compounds. The presence of the furan ring contributes to its unique chemical properties, including potential applications in pharmaceuticals and agrochemicals. However, due to the reactivity of the carbonyl chloride group, it must be handled with care, as it can release hydrochloric acid upon hydrolysis. Safety precautions are essential when working with this compound, as it may pose health hazards if inhaled or if it comes into contact with skin.

Formula: C₅H₇ClO₂

InChI: InChI=1S/C5H7ClO2/c6-5(7)4-2-1-3-8-4/h4H,1-3H2

InChI key: InChIKey=DVCFNCQPOANJGU-UHFFFAOYSA-N

SMILES: C(Cl)(=O)C1CCCO1

Synonyms:

• 2-Furancarbonyl chloride, tetrahydro-
• Tetrahydro-2-furancarbonyl chloride
• Tetrahydrofuranyl-2-carbonyl chloride
• Tetrahydro-2-furoyl chloride
• 2-Furoyl chloride, tetrahydro-

Oxolane-2-Carbonyl Chloride

CAS: 52449-98-6

Oxolane-2-Carbonyl Chloride

Purity: 95%

Molecular weight: 134.56g/mol

Ref: 54-OR1014566

Tetrahydrofuranyl-2-carbonyl Chloride

CAS: 52449-98-6

Tetrahydrofuranyl-2-carbonyl Chloride is a reactive chemical that has been used in the treatment of pediatric cancer. It is a prodrug that undergoes enzymatic hydrolysis to release an active form of hydrochloric acid, which is cytotoxic and induces apoptosis in cells. Tetrahydrofuranyl-2-carbonyl Chloride binds to annexin, which triggers the activation of caspases and leads to the cleavage of poly(ADP-ribose) polymerase (PARP). This cleavage leads to mitochondrial membrane depolarization and subsequent cell death. The x-ray structures of tetrahydrofuranyl-2-carbonyl chloride show that it has an unsymmetrical carbonyl group. When it reacts with chloride ions, it forms an intermediate with a carbonyl group on one side and a bromide ion on the other. This intermediate can then react with

Formula: C₅H₇ClO₂

Purity: Min. 95%

Molecular weight: 134.56 g/mol

Ref: 3D-CCA44998