CAS 52468-60-7

Flunarizine

Description:

Flunarizine is a calcium channel blocker primarily used as a medication for the prevention of migraines and the treatment of certain types of vertigo. It is classified as a selective calcium antagonist, which means it inhibits the influx of calcium ions through voltage-gated calcium channels, thereby affecting vascular smooth muscle and neuronal excitability. Flunarizine is known for its neuroprotective properties and is also utilized in managing conditions like vestibular disorders and certain movement disorders, such as Parkinson's disease. The substance is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Its chemical structure features a diphenylmethylpiperazine moiety, contributing to its pharmacological effects. Common side effects may include sedation, weight gain, and gastrointestinal disturbances. Flunarizine is not widely available in all countries, and its use may be restricted due to potential side effects and the availability of alternative treatments. Overall, it is a unique compound with specific therapeutic applications in neurology and vascular health.

Formula: C₂₆H₂₆F₂N₂

InChI: InChI=1S/C26H26F2N2/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21/h1-15,26H,16-20H2/b7-4+

InChI key: InChIKey=SMANXXCATUTDDT-QPJJXVBHSA-N

SMILES: C(N1CCN(C/C=C/C2=CC=CC=C2)CC1)(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4

Synonyms:

• 1-[Bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]piperazine
• Flunarizin
• Flunarizina
• Flunarizine
• Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)-, (E)-
• Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propen-1-yl]-
• Sibelium
• Piperazine, 1-[bis(4-fluorophenyl)methyl]-4-[(2E)-3-phenyl-2-propenyl]-

Flunarizine

CAS: 52468-60-7

Formula: C₂₆H₂₆F₂N₂

Purity: %

Color and Shape: Solid

Molecular weight: 404.4948

Ref: IN-DA00DDSC

Flunarizine

CAS: 52468-60-7

Flunarizine

Purity: 98+%

Molecular weight: 404.49g/mol

Ref: 54-PC1002105

Flunarizine

CAS: 52468-60-7

Flunarizine is an orally administered peripheral vasodilator, a dual blocker of voltage-gated Na+/Ca2+ channels and a D2 dopamine receptor antagonist.

Formula: C₂₆H₂₆F₂N₂

Purity: 99.9%

Color and Shape: Solid

Molecular weight: 404.50

Ref: TM-T21392

Flunarizine N,N-Dioxide

Controlled Product

CAS: 52468-60-7

Formula: C₂₆H₂₆F₂N₂O₂

Color and Shape: Neat

Molecular weight: 436.494

Ref: TR-F455210