CAS 52485-79-7

Buprenorphine

Description:

Buprenorphine is a semi-synthetic opioid derived from thebaine, primarily used in the treatment of opioid addiction and pain management. It acts as a partial agonist at the mu-opioid receptor, providing analgesic effects while also having a ceiling effect that reduces the risk of overdose compared to full agonists. Buprenorphine is characterized by its high affinity for opioid receptors, which allows it to displace other opioids, making it effective in withdrawal management. It is typically administered sublingually or via transdermal patches, and its pharmacokinetics include a long half-life, allowing for once-daily dosing in many cases. The substance is classified as a Schedule III controlled substance in many jurisdictions due to its potential for abuse and dependence. Common side effects may include nausea, constipation, and sedation, while serious risks involve respiratory depression, particularly when combined with other central nervous system depressants. Overall, buprenorphine plays a significant role in harm reduction strategies and chronic pain management.

Formula:C₂₉H₄₁NO₄

InChI:InChI=1S/C29H41NO4/c1-25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-28(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)28/h8-9,17,20-21,24,31-32H,6-7,10-16H2,1-5H3/t20-,21-,24-,26+,27-,28+,29-/m1/s1

InChI key:InChIKey=RMRJXGBAOAMLHD-IHFGGWKQSA-N

SMILES:O(C)[C@@]12[C@]3([C@]45[C@@]([C@](N(CC6CC6)CC4)(CC7=C5C(O3)=C(O)C=C7)[H])(C[C@@]1([C@](C(C)(C)C)(C)O)[H])CC2)[H]

Synonyms:

(αS,5α,7α)-17-(Cyclopropylmethyl)-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α-methyl-6,14-ethenomorphinan-7-methanol
17-cyclopropylmethyl-4,5a-epoxy-7a[(S)-1-hydroxy-1,2,2-trimethyl-propyl]-6-methoxy-6,14-endo-ethanomorphinan3-ol
6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α-methyl-, [5α,7α(S)]-
Buprecare
Buprenorfina
Buprenorfine
Buprenorphin
Buprenorphine
Butrans
Buvidal
CAM 2038 FluidCrystal
Cam 2038
Norspan
Norvex
Rx 6029M
Sublocade
Subutex
Temgesic
Transtec
(5alpha,6beta,14beta,18R)-17-(Cyclopropylmethyl)-18-[(2S)-2-hydroxy-3,3-dimethyl-2-butanyl]-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
(5alpha,6beta,14beta,18R)-17-(cyclopropylmethyl)-18-[(1S)-1-hydroxy-1,2,2-trimethylpropyl]-6-(methyloxy)-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
(5alpha,6beta,14beta,18R)-17-(cyclopropylmethyl)-18-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
[5a,7a(S)]-17-(Cyclopropylmethyl)-a-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-a-methyl-6,14-ethanomorphinan-7-methanol
21-Cyclopropyl-7a-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endoethano-6,7,8,14-tetrahydrooripavine
258-396-8
(5alpha,14beta,18R)-17-(cyclopropylmethyl)-18-[(1S)-1-hydroxy-1,2,2-trimethylpropyl]-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
21-Cyclopropyl-7a-(2-hydroxy-3,3-dimethyl-2-butyl)-6,14-endoethano-6,7,8,14-tetrahydrooripavine
6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-α-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-α-methyl-, (αS,5α,7α)-
(5alpha,14beta,18R)-17-(Cyclopropylmethyl)-18-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
See more synonyms

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Found 8 products.

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Buprenorphine
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 52485-79-7
Color and Shape:Neat
Ref: 61-FOR0120.00
10mg
338.00€
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Buprenorphine 0.1 mg/ml in Methanol
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 52485-79-7
Color and Shape:Single Solution
Ref: 61-AMP0120.00-02
1ml
84.00€
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Buprenorphine 1.0 mg/ml in Methanol
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 52485-79-7
Color and Shape:Single Solution
Ref: 61-AMP0120.00-01
1ml
95.00€
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Buprenorphine
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 52485-79-7
Color and Shape:Neat
Ref: 86-MM0120.00
250mg
849.00€
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Buprenorphine
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 52485-79-7
Applications Buprenorphine is a controlled substance (narcotic). Analgesic that demonstrates narcotic agonist-antagonist properties. References Martin, W.R., et al.: J. Pharmacol. Exp. Ther., 197, 517 (1976), Rance, M.J., Biochem. Pharmacol., 25, 735 (1976), Heel, R.C., et al.: Drugs, 17, 81 (1979), 
Formula:C₂₉H₄₁NO₄
Color and Shape:Neat
Molecular weight:467.64
Ref: TR-B689755
5mg
135.00€
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10mg
257.00€
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50mg
926.00€
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BUPRENORPHINE CRS - * PSY
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 52485-79-7
BUPRENORPHINE CRS - * PSY
Formula:C₂₉H₄₁NO₄
Color and Shape:Crystalline Powder. White. Powder., Crystalline Powder. White. Powder.
Molecular weight:467.6401
Ref: 41-Y0001108
10mg
115.00€
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BUPRENORPHINE FOR SYSTEM SUITABILITY CRS - * PSY
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 52485-79-7
BUPRENORPHINE FOR SYSTEM SUITABILITY CRS - * PSY
Formula:C₂₉H₄₁NO₄
Color and Shape:Crystalline Powder. White. Powder.
Molecular weight:467.6401
Ref: 41-Y0001122
10mg
115.00€
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Buprenorphine (1 mg/ml in Acetonitrile)
Controlled ProductPlease note that this is a controlled product in some countries, and needs to be treated in accordance with the relevant regulations. Be aware this might entail additional expenses and documentation.
CAS:
- 52485-79-7
Formula:C₂₉H₄₁NO₄
Color and Shape:Single Solution
Molecular weight:467.64
Ref: TR-KIT3415
5x1ml
1,136.00€
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