CAS 52497-36-6

Dihydrokainic acid

Description:

Dihydrokainic acid is a chemical compound that serves as a potent inhibitor of the excitatory amino acid transporter (EAAT), particularly EAAT2, which is crucial for the regulation of glutamate levels in the central nervous system. This compound is characterized by its structural features, which include a bicyclic structure that contributes to its biological activity. Dihydrokainic acid is often studied for its potential neuroprotective effects and its role in modulating synaptic transmission, making it of interest in neurological research. The compound is typically soluble in water and exhibits stability under standard laboratory conditions. Its pharmacological properties have led to investigations into its therapeutic potential for conditions associated with glutamate dysregulation, such as epilepsy and neurodegenerative diseases. As with many chemical substances, handling dihydrokainic acid requires adherence to safety protocols to mitigate any potential risks associated with its use in research and development.

Formula: C₁₀H₁₇NO₄

InChI: InChI=1S/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1

InChI key: InChIKey=JQPDCKOQOOQUSC-OOZYFLPDSA-N

SMILES: C(C(O)=O)[C@H]1[C@@H]([C@H](C)C)CN[C@@H]1C(O)=O

Synonyms:

• (2S,3S,4R)-2-Carboxy-4-(1-methylethyl)-3-pyrrolidineacetic acid
• (2S-(2alpha,3beta,4beta))-2-Carboxy-4-(1-methylethyl)-3-pyrrolidineacetic acid
• (3S,4R)-3-(carboxymethyl)-4-propan-2-yl-L-proline
• 3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethyl)-, (2S,3S,4R)-
• 3-Pyrrolidineacetic acid, 2-carboxy-4-(1-methylethyl)-, [2S-(2α,3β,4β)]-
• Dihydrokainate
• α-Dihydrokainic acid
• Dihydrokainic acid

Dihydrokainic acid

CAS: 52497-36-6

Formula: C₁₀H₁₇NO₄

Molecular weight: 215.25

Ref: 7W-GL2978

Dihydrokainic Acid

Controlled Product

CAS: 52497-36-6

Applications Dihydrokainic acid is an EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake.
References Grunewald, M., et al.: J. Biol. Chem., 275, 9684 (2000); Shimamoto, K., et al.: Mol. Pharmacol., 53, 195 (1998);

Formula: C₁₀H₁₇NO₄

Color and Shape: Neat

Molecular weight: 215.246

Ref: TR-D450623

Dihydrokainic acid

CAS: 52497-36-6

Non-transportable inhibitor of GLT-1 glutamate transporter

Formula: C₁₀H₁₇NO₄

Purity: Min. 95%

Molecular weight: 215.25 g/mol

Ref: 3D-XD160600

Dihydrokainic acid

CAS: 52497-36-6

EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake

Formula: C₁₀H₁₇NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 215.25

Ref: TM-T22722