CAS 525-57-5

Harmalol

Description:

Harmalol, with the CAS number 525-57-5, is an alkaloid derived from the seeds of the Peganum harmala plant, commonly known as Syrian rue. It is a member of the beta-carboline family and is structurally related to other compounds such as harmine and harmaline. Harmalol is known for its psychoactive properties and has been studied for its potential effects on the central nervous system, including its role as a monoamine oxidase inhibitor (MAOI). This characteristic can lead to interactions with various medications and dietary substances, necessitating caution in its use. The compound exhibits a range of biological activities, including antioxidant and neuroprotective effects, which have garnered interest in pharmacological research. Harmalol is typically encountered in a crystalline form and is soluble in organic solvents. Its safety profile and therapeutic potential continue to be explored, particularly in the context of traditional medicine and modern pharmacology. As with many alkaloids, the effects and safety of harmalol can vary significantly based on dosage and individual response.

Formula: C₁₂H₁₂N₂O

InChI: InChI=1S/C12H12N2O/c1-7-12-10(4-5-13-7)9-3-2-8(15)6-11(9)14-12/h2-3,6,14-15H,4-5H2,1H3

InChI key: InChIKey=RHVPEFQDYMMNSY-UHFFFAOYSA-N

SMILES: CC=1C2=C(C=3C(N2)=CC(O)=CC3)CCN1

Synonyms:

• 1-Methyl-3H,4H,9H-pyrido[3,4-b]indol-7-ol
• 1-Methyl-4,9-dihydro-3H-pyrido[3,4-b]indol-7-ol
• 1-methyl-2,3,4,9-tetrahydro-7H-beta-carbolin-7-one
• 1-methyl-4,9-dihydro-3H-β-carbolin-7-ol
• 11-Hydroxyharmalan
• 3H-Pyrido(3,4-b)indol-7-ol, 4,9-dihydro-1-methyl- (8CI)(9CI)
• 3H-Pyrido[3,4-b]indol-7-ol, 4,9-dihydro-1-methyl-
• 4,9-Dihydro-1-methyl-3H-pyrido(3,4-b)indol-7-ol
• Harmidol
• Harmolol
• Nsc 72293

Harmalol

CAS: 525-57-5

Formula: C₁₂H₁₂N₂O

Molecular weight: 200.24

Ref: 7W-GP8588

Harmalol

CAS: 525-57-5

Formula: C₁₂H₁₂N₂O

Purity: 95%~99%

Molecular weight: 200.241

Ref: BP-BP0698

Harmalol

CAS: 525-57-5

Harmalol (Harmidol) is a bioactive beta-carboline and a member of the harmala alkaloids

Formula: C₁₂H₁₂N₂O

Purity: 98.94%

Color and Shape: Solid

Molecular weight: 200.24

Ref: TM-T8770

Harmalol

Controlled Product

CAS: 525-57-5

Harmalol is a reactive compound that is found in the seeds of Peganum harmala, also known as Syrian rue. Harmalol is an inhibitor of mitochondrial membrane potential and has been shown to interact with drugs that are metabolized by cytochrome P450. It also inhibits the activity of enzymes such as monoamine oxidase and phosphodiesterase. Harmalol has been shown to be cytotoxic to murine hepatoma cells and induce apoptosis via reactive oxygen species-mediated mechanisms. The molecular docking analysis reveals that harmalol binds to DNA through hydrogen bonding interactions with guanine bases on the DNA molecule. This binding may lead to DNA damage and cell death.

Formula: C₁₂H₁₂N₂O

Purity: Min. 95%

Color and Shape: Clear Liquid

Molecular weight: 200.24 g/mol

Ref: 3D-FH57648

Harmalol

Controlled Product

CAS: 525-57-5

Stability Hygroscopic
Applications Harmalol maintains a high DNA binding and apoptotic induction ability in HepG2 cells. Acetylcholinesterase inhibitor.
References Sarkar, S. et al.: Chem. Biol-Interact., 258, 142 (2016); Yang, Y. et al.: J. Ethnopharmacol., 168, 279 (2015);

Formula: C₁₂H₁₂N₂O

Color and Shape: Dark Yellow To Dark Orange

Molecular weight: 200.24

Ref: TR-H105150