CAS 525-66-6

Propranolol

Description:

Propranolol is a non-selective beta-adrenergic antagonist, commonly used as a medication to manage various cardiovascular conditions, including hypertension, anxiety, and migraine prophylaxis. Its chemical formula is C16H21NO2, and it features a naphthalene ring structure, which contributes to its lipophilicity and ability to cross the blood-brain barrier. Propranolol works by blocking the action of epinephrine and norepinephrine on beta receptors, leading to decreased heart rate and blood pressure. It is typically administered orally, but can also be given intravenously in acute settings. The drug has a relatively short half-life, necessitating multiple daily doses for sustained effect. Side effects may include fatigue, dizziness, and gastrointestinal disturbances, and it is contraindicated in patients with certain respiratory conditions, such as asthma, due to its non-selective nature. Propranolol's ability to modulate physiological responses makes it a versatile agent in both cardiovascular and psychiatric treatments.

Formula: C₁₆H₂₁NO₂

InChI: InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3

InChI key: InChIKey=AQHHHDLHHXJYJD-UHFFFAOYSA-N

SMILES: O(CC(CNC(C)C)O)C=1C2=C(C=CC1)C=CC=C2

Synonyms:

• (.+-.)-Propranolol
• 1-(1-Naphthyloxy)-3-(isopropylamino)-2-propanol
• 1-(Isopropylamino)-3-(1'-naphthyloxy)-2-propanol
• 1-(Naphthalen-1-yloxy)-3-[(propan-2-yl)amino]propan-2-ol
• 1-Isopropylamino-3-naphthalen-1-yloxypropan-2-ol
• 1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol
• 1-[(Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol
• 2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)-
• 3-(Naphth-1-yloxy)-1-(isopropylamino)propan-2-ol
• <span class="text-smallcaps">DL</span>-Propranolol
• Ay 64043
• Betalong
• DL-Propranolol
• Euprovasin
• Innopran XL
• Proprasylyt
• Racemic propranolol
• Reducor
• [2-Hydroxy-3-(naphthalen-1-yloxy)propyl](propan-2-yl)amine
• β-Propranolol
• 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-
• 1-Isopropylamino-3-(naphthalen-1-yloxy)-propan-2-ol
• Propranolol Base
• 1-isopropylamino-3-(1-naphthyloxy)propan-2-ol
• 208-378-0
• 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)- (9CI)
• 1-Propanolol
• Avlocardyl
• 2-Propanol, 1-(isopropylamino)-3-(1-naphthyloxy)- (7CI, 8CI)
• Avlocanol
• PROPANALOL
• 1-Isopropylamino-3-(1-naphtyloxy)-2-propanol
• 1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol
• Proprasylyte

Propranolol Hydrochloride

CAS: 318-98-9, 525-66-6

Formula: C₁₆H₂₁NO₂·HCl

Purity: >99.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 295.81

Ref: 3B-P0995

rac-Propanolol

CAS: 525-66-6

Applications β−Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II).
References Blaes, A. H., et al.: Clin. Cancer Res., 26, 1781 (2020); Zaccara, G., et al.: Acta Neurol. Scand., 142, 37 (2020)

Formula: C₁₆H₂₁NO₂

Color and Shape: White To Off-White

Molecular weight: 259.34

Ref: TR-P840013