CAS 5251-34-3

Cloprednol

Description:

Cloprednol, with the CAS number 5251-34-3, is a synthetic corticosteroid that exhibits anti-inflammatory and immunosuppressive properties. It is primarily used in the treatment of various inflammatory conditions, including skin disorders and respiratory issues. Cloprednol functions by modulating the immune response and inhibiting the release of inflammatory mediators, thereby reducing symptoms such as swelling, redness, and itching. The compound is characterized by its ability to penetrate biological membranes, allowing for effective topical or systemic administration. Cloprednol is typically formulated in various dosage forms, including creams, ointments, and inhalers, depending on the intended therapeutic application. As with other corticosteroids, its use may be associated with potential side effects, particularly with prolonged use, such as skin thinning or systemic effects if absorbed in significant amounts. Therefore, it is essential to use Cloprednol under medical supervision to ensure appropriate dosing and minimize adverse effects.

Formula: C₂₁H₂₅ClO₅

InChI: InChI=1S/C21H25ClO5/c1-19-5-3-11(24)7-14(19)15(22)8-12-13-4-6-21(27,17(26)10-23)20(13,2)9-16(25)18(12)19/h3,5,7-8,12-13,16,18,23,25,27H,4,6,9-10H2,1-2H3/t12-,13-,16-,18+,19-,20-,21-/m0/s1

InChI key: InChIKey=YTJIBEDMAQUYSZ-FDNPDPBUSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(C(Cl)=C3)=CC(=O)C=C4)([C@@H](O)C1)[H])[H])(CC[C@@]2(C(CO)=O)O)[H]

Synonyms:

• (11Beta)-6-Chloro-11,17,21-Trihydroxypregna-1,4,6-Triene-3,20-Dione
• (11β)-6-Chloro-11,17,21-trihydroxypregna-1,4,6-triene-3,20-dione
• (8Xi,10Xi,11Beta,13Xi)-6-Chloro-11,17,21-Trihydroxypregna-1,4,6-Triene-3,20-Dione
• 6-Chloro-11beta,17,21-trihydroxypregna-1,4,6-triene-3,20-dione
• 6-Chloro-11beta,17alpha, 21-trihydroxypregn-1,4,6-triene-3,20-dione
• Cloprednol [USAN:INN:BAN]
• Cloprednole
• Cloprednolum
• Cloprednolum [INN-Latin]
• Cloradryn
• Novacort
• Pregna-1,4,6-triene-3,20-dione, 6-chloro-11,17,21-trihydroxy-, (11beta)-
• Pregna-1,4,6-triene-3,20-dione, 6-chloro-11,17,21-trihydroxy-, (11β)-
• Pregna-1,4,6-triene-3,20-dione, 6-chloro-11β,17,21-trihydroxy-
• Rs 4691
• Synestan
• Syntestan
• Unii-Syp56O3Gjg
• Cloprednol

Cloprednol

Controlled Product

CAS: 5251-34-3

Applications A systematic corticosteroid. Anti-inflammatory.
References Mroszczak, E.J. et al.: J. Pharmac. Sci., 67, 920 (1978); Moellmann, H. et al.: Int. J. Clin. Pharmacol. Therap., 34, 1 (1996);

Formula: C₂₁H₂₅ClO₅

Color and Shape: Neat

Molecular weight: 392.87

Ref: TR-C587295

Cloprednol

Controlled Product

CAS: 5251-34-3

Cloprednol is an anti-infective agent that belongs to the group of aziridine derivatives. It is a synthetic analog of prednisolone, which has been shown to inhibit the inflammatory response in the intestine. Cloprednol has been shown to be highly biocompatible and its long-term efficacy against microbial infection has been demonstrated by kinetic data. This drug also inhibits choroidal neovascularization, which is a major cause of blindness in patients with age-related macular degeneration. Cloprednol is used for the treatment of bowel diseases such as Crohn’s disease and ulcerative colitis. It also has been shown to be effective in treating autoimmune diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus.

Formula: C₂₁H₂₅ClO₅

Purity: Min. 95%

Molecular weight: 392.87 g/mol

Ref: 3D-FC20516