CAS 52619-21-3

Pregna-1,4-diene-3,20-dione, 9,11-epoxy-21-hydroxy-16-methyl-17-[(1-oxopentyl)oxy]-, (9β,11β,16β)-

Description:

Pregna-1,4-diene-3,20-dione, 9,11-epoxy-21-hydroxy-16-methyl-17-[(1-oxopentyl)oxy]-, (9β,11β,16β)-, commonly known by its CAS number 52619-21-3, is a synthetic steroid compound that exhibits characteristics typical of glucocorticoids. This compound features a complex steroid structure with multiple functional groups, including a diene system, an epoxy group, and a hydroxyl group, which contribute to its biological activity. The presence of the 1-oxopentyl group suggests potential lipophilicity, influencing its pharmacokinetics and interaction with biological membranes. Its stereochemistry, indicated by the (9β,11β,16β) configuration, is crucial for its receptor binding and subsequent physiological effects. This compound may exhibit anti-inflammatory and immunosuppressive properties, making it of interest in therapeutic applications. However, its specific biological activities, efficacy, and safety profile would require further investigation through pharmacological studies. Overall, this compound represents a significant class of steroids with potential applications in medicine, particularly in the treatment of inflammatory and autoimmune conditions.

Formula: C₂₇H₃₆O₆

InChI: InChI=1S/C27H36O6/c1-5-6-7-23(31)33-26(21(30)15-28)16(2)12-20-19-9-8-17-13-18(29)10-11-24(17,3)27(19)22(32-27)14-25(20,26)4/h10-11,13,16,19-20,22,28H,5-9,12,14-15H2,1-4H3/t16-,19-,20-,22-,24-,25-,26-,27+/m0/s1

InChI key: InChIKey=YAGOAMKGOXDNJR-OOOOKSNHSA-N

SMILES: C[C@@]12[C@@]34[C@@](O3)(C[C@@]5(C)[C@]([C@@]4(CCC1=CC(=O)C=C2)[H])(C[C@H](C)[C@]5(OC(CCCC)=O)C(CO)=O)[H])[H]

Synonyms:

• 9,11-Epoxy-9H-cyclopenta[a]phenanthrene, pregna-1,4-diene-3,20-dione deriv.
• Pregna-1,4-diene-3,20-dione, 9,11-epoxy-21-hydroxy-16-methyl-17-[(1-oxopentyl)oxy]-, (9β,11β,16β)-

Betamethasone Impurity 26

CAS: 52619-21-3

Formula: C₂₇H₃₆O₆

Molecular weight: 456.58

Ref: 4Z-B-065072

16-Methylepoxide-17-valerate

Controlled Product

CAS: 52619-21-3

Applications 16-Methylepoxide-17-valerate are used in the synthesis of 21-esters of Betamethasone (B327000), a glucocorticoid used as an anti-inflammatory agent.
References Ferrante, M.G., et al.: Anal. Profiles Drug Subs., 6, 43 (1977), Li, A., et al.: Chem. Biol. Interact., 142, 7 (2002), Cruz-Monteagudo, M., et al.: Eur. J. Med. Chem., 40, 1030 (2005), Rothfuss, A., et al.: Chem. Res. Toxicol., 19, 1313 (2006),

Formula: C₂₇H₃₆O₆

Color and Shape: Neat

Molecular weight: 456.571

Ref: TR-M493055

16-Methylepoxide-17-Valerate

CAS: 52619-21-3

Formula: C₂₇H₃₆O₆

Molecular weight: 456.58

Ref: ST-EA-CP-B25040