CAS 52659-37-7

GM1-Pentasaccharide

CAS: 52659-37-7

Purity: ≥ 95%

Color and Shape: White to off-white powder or solid

Ref: 7W-GC9063

GM1-Pentasaccharide

CAS: 52659-37-7

GM1 pentasaccharide (sodium salt) has a core tetrasaccharide structure (Galβ1,3GalNAcβ1,4Galβ1,4Glc) with a single sialic acid residue linked α2,3 to the inner galactose residue (Ledeen, 2009). GM1 pentasaccahride is the carbohydrate moiety of GM1 ganglioside. GM1 ganglioside interacts and modulates tyrosine kinases, such a,s neural tropomyosin receptor kinase A (TrkA), by inducing the release of neurotrophins from fibroblast cells and the epidermal growth factor receptor (EGFR) (Higuero, 2009). GM1 ganglioside is also found in epithelial membranes; it is a key element for bacterial toxicity and viral infection as it acts as a receptor for the B-subunits of heat-labile toxin, cholera toxin, rotavirus, and simian virus 40. GM1 ganglioside also has the ability to bind amyloid-β proteins and is involved in Alzheimer’s pathogenesis (Chiricozzi, 2020).

Formula: C₃₇H₆₂N₂O₂₉

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 998.88 g/mol

Ref: 3D-OP03880