CAS 527-75-3

Erythromycin B

Description:

Erythromycin B is a macrolide antibiotic that is primarily derived from the bacterium Saccharopolyspora erythraea. It is characterized by its large lactone ring structure, which is essential for its antibacterial activity. Erythromycin B exhibits a broad spectrum of activity against various Gram-positive bacteria and some Gram-negative bacteria, making it effective in treating respiratory tract infections, skin infections, and certain sexually transmitted diseases. The compound works by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit, thereby preventing the growth and reproduction of bacteria. Erythromycin B is known for its relatively low toxicity and is often used as an alternative for patients allergic to penicillin. However, it can cause gastrointestinal side effects and may interact with other medications due to its effect on liver enzymes. Its stability is influenced by pH and temperature, and it is typically administered in the form of tablets or as a topical ointment. Overall, Erythromycin B remains an important antibiotic in clinical use, particularly in treating infections caused by susceptible organisms.

Formula: C₃₇H₆₇NO₁₂

InChI: InChI=1S/C37H67NO12/c1-14-26-20(4)29(40)21(5)28(39)18(2)16-36(9,44)33(50-35-30(41)25(38(11)12)15-19(3)46-35)22(6)31(23(7)34(43)48-26)49-27-17-37(10,45-13)32(42)24(8)47-27/h18-27,29-33,35,40-42,44H,14-17H2,1-13H3/t18-,19-,20+,21+,22+,23-,24+,25+,26-,27+,29+,30-,31+,32+,33-,35+,36-,37-/m1/s1

InChI key: InChIKey=IDRYSCOQVVUBIJ-PPGFLMPOSA-N

SMILES: O([C@@H]1[C@@H](C)[C@H](O[C@H]2C[C@](OC)(C)[C@@H](O)[C@H](C)O2)[C@@H](C)C(=O)O[C@H](CC)[C@H](C)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]1(C)O)[C@H]3[C@H](O)[C@@H](N(C)C)C[C@@H](C)O3

Synonyms:

• (3R,4S,5S,6R,7R,9R,11S,12S,13R,14S)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12-dihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione (non-preferred name)
• (3R,4S,6R,7R,9R,11R,12S,13R,14R)-6-{[4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12-dihydroxy-4-[(5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy]-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione (non-preferred name)
• 12-Deoxyerythromycin
• Abbot 24091
• Abbott 24091
• Beritromicina
• Beritromicina [INN-Spanish]
• Berythromycin [USAN:INN]
• Berythromycine
• Berythromycine [INN-French]
• Berythromycinum
• Berythromycinum [INN-Latin]
• Brn 5206722
• Erythromycin B
• Erythromycin, 12-deoxy-
• Oxacyclotetradecane, erythromycin deriv.
• Berythromycin

ERYTHROMYCIN B CRS

CAS: 527-75-3

ERYTHROMYCIN B CRS

Ref: 41-E1310000

ERYTHROMYCIN B RS

CAS: 527-75-3

ERYTHROMYCIN B RS

Formula: C₃₇H₆₇NO₁₂

Molecular weight: 717.9274

Ref: 41-ICRS0299

Erythromycin B

CAS: 527-75-3

Erythromycin and its derivatives; salts thereof

Formula: C₃₇H₆₇NO₁₂

Color and Shape: White Powder

Molecular weight: 717.46633

Ref: 45-1242010

ERYTHROMYCIN B (150 MG)

CAS: 527-75-3

Formula: C₃₇H₆₇NO₁₂

Purity: 90%

Color and Shape: Solid

Molecular weight: 717.9274

Ref: IN-DA00DEY1

Erythromycin B

CAS: 527-75-3

Formula: C₃₇H₆₇NO₁₂

Molecular weight: 717.95

Ref: 4Z-E-2011

Erythromycin B (~90%)

Controlled Product

CAS: 527-75-3

Applications Erythromycin B is a co-metabolite of Erythromycin A (E649950), an antibacterial agent.
References Minh, N. et al.: Int. Food. Res. J., 18, 95 (2011); Koch, W.L. et al.: Anal. Profiles Drug Subs., 8, 157 (1979);

Formula: C₃₇H₆₇NO₁₂

Purity: ~90%

Color and Shape: Neat

Molecular weight: 717.93

Ref: TR-E649975

Erythromycin B

CAS: 527-75-3

Erythromycin B is a semisynthetic macrolide antibiotic, which is derived from the actinomycete *Saccharopolyspora erythraea*. Its mode of action involves inhibiting bacterial protein synthesis by binding to the 50S ribosomal subunit. This interference with protein synthesis effectively hampers bacterial growth, making it a potent bacteriostatic agent.

Formula: C₃₇H₆₇NO₁₂

Purity: 90%Nmr

Molecular weight: 717.93 g/mol

Ref: 3D-AE45530

Erythromycin B

CAS: 527-75-3

Formula: C₃₇H₆₇NO₁₂

Molecular weight: 717.94

Ref: ST-EA-CP-E18022

Erythromycin B

CAS: 527-75-3

Erythromycin B exhibits antimalarial activity by effectively inhibiting the asexual growth of Plasmodium falciparum.

Formula: C₃₇H₆₇NO₁₂

Color and Shape: Solid

Molecular weight: 717.93

Ref: TM-T201497

Erythromycin B

CAS: 527-75-3

Erythromycin B

Formula: C₃₇H₆₇NO₁₂

Purity: 98.7%

Color and Shape: White

Molecular weight: 717.46633

Ref: 47-795