CAS 5270-74-6

2-[3-(Aminosulfonyl)-4-chlorobenzoyl]benzoic acid

Description:

2-[3-(Aminosulfonyl)-4-chlorobenzoyl]benzoic acid, with the CAS number 5270-74-6, is a chemical compound that belongs to the class of benzoic acids. This substance features a benzoic acid moiety substituted with a 4-chloro group and an aminosulfonyl group at the ortho position. It is characterized by its sulfonamide functional group, which contributes to its potential biological activity, including anti-inflammatory and analgesic properties. The presence of the chlorine atom enhances its reactivity and may influence its pharmacological profile. This compound is typically a solid at room temperature and is soluble in polar solvents, which is common for many benzoic acid derivatives. Its structural complexity allows for various interactions in biological systems, making it of interest in medicinal chemistry. Safety and handling precautions should be observed, as with many chemical substances, due to potential toxicity or reactivity. Overall, 2-[3-(Aminosulfonyl)-4-chlorobenzoyl]benzoic acid is a notable compound in the field of pharmaceutical research.

Formula: C₁₄H₁₀ClNO₅S

InChI: InChI=1S/C14H10ClNO5S/c15-11-6-5-8(7-12(11)22(16,20)21)13(17)9-3-1-2-4-10(9)14(18)19/h1-7H,(H,18,19)(H2,16,20,21)

InChI key: InChIKey=UKRADWWBRBBJLZ-UHFFFAOYSA-N

SMILES: C(=O)(C1=C(C(O)=O)C=CC=C1)C2=CC(S(N)(=O)=O)=C(Cl)C=C2

Synonyms:

• 2-(4-Chloro-3-Sulfamoylbenzoyl)Benzoic Acid
• 2-[3-(Aminosulfonyl)-4-chlorobenzoyl]benzoic acid
• Benzoic acid, 2-[3-(aminosulfonyl)-4-chlorobenzoyl]-
• Benzoic acid, o-(4-chloro-3-sulfamoylbenzoyl)-
• 2-(4-Chloro-3-sulphamoylbenzoyl)benzoic acid

Chlortalidone impurity B

CAS: 5270-74-6

Chlortalidone impurity B

Color and Shape: Off-White

Ref: 47-75

Chlorthalidone Related Compound A (4'-Chloro-3'-sulfamoyl-2-benzophenone Carboxylic Acid)

CAS: 5270-74-6

Sulfonamides, nesoi

Formula: C₁₄H₁₀ClNO₅S

Color and Shape: White Crystalline Powder

Molecular weight: 338.99682

Ref: 45-1119309

2-(4-Chloro-3-Sulphamoylbenzoyl)Benzoic Acid

CAS: 5270-74-6

Formula: C₁₄H₁₀ClNO₅S

Purity: 99%

Color and Shape: Solid

Molecular weight: 339.7509

Ref: IN-DA00DF1E

2-(4-Chloro-3-sulfamoylbenzoyl)benzoic acid

CAS: 5270-74-6

2-(4-Chloro-3-sulfamoylbenzoyl)benzoic acid

Purity: 99%

Molecular weight: 339.76g/mol

Ref: 54-OR1066773

Chlortalidone EP Impurity B (Chlorthalidone USP Related Compound A)

CAS: 5270-74-6

Formula: C₁₄H₁₀ClNO₅S

Color and Shape: White To Off-White Solid

Molecular weight: 339.75

Ref: 4Z-C-140001

2-(4-Chloro-3-sulfamoylbenzoyl)benzoic Acid

Controlled Product

CAS: 5270-74-6

Formula: C₁₄H₁₀ClNO₅S

Color and Shape: Neat

Molecular weight: 339.75

Ref: 86-MM0297.02

2-[3-(Aminosulfonyl)-4-chlorobenzoyl]-benzonic Acid

Controlled Product

CAS: 5270-74-6

Applications 2-[3-(Aminosulfonyl)-4-chlorobenzoyl]-benzonic Acid is a potential metabolite of Chlorthalidone.
References Salado C., et al.: J. Chromatography. Biomed. App., 690, 195 (1997);

Formula: C₁₄H₁₀ClNO₅S

Color and Shape: Neat

Molecular weight: 339.75

Ref: TR-A633000

Chlortalidone EP Impurity B

CAS: 5270-74-6

Formula: C₁₄H₁₀ClNO₅S

Molecular weight: 339.75

Ref: ST-EA-CP-C20002

2-(4-CHLORO-3-SULFAMOYLBENZOYL)BENZOIC ACID

CAS: 5270-74-6

Formula: C₁₄H₁₀ClNO₅S

Purity: 99%

Molecular weight: 339.75

Ref: 10-F538210

Chlorthalidone impurity A

CAS: 5270-74-6

Chlorthalidone impurity A is an impurity in Chlorthalidone. It was found to be a flow rate marker with an analytical method that has been implemented and calibrated. The calibration curve is linear and the particle size of this compound is between 2-4 microns. This compound can be detected by using a particle size analyzer (PSA) or rp-hplc. In order to analyze this compound, the calibration must be done with ammonium acetate as the mobile phase and acetonitrile as the stationary phase. The wavelength for detection is 220 nm and the runtime is 1 minute. Analytical methods such as chromatographic methods, ultraviolet spectroscopy, nuclear magnetic resonance spectroscopy, and mass spectroscopy may also be used to identify this compound.

Formula: C₁₄H₁₀ClNO₅S

Purity: Min. 95%

Molecular weight: 339.75 g/mol

Ref: 3D-IC75148

Chlorthalidone impurity

CAS: 5270-74-6

Chlorthalidone impurity, a metabolite of the thiazide-like diuretic Chlorthalidone, is utilized in the management of hypertension [1] [2].

Formula: C₁₄H₁₀ClNO₅S

Color and Shape: Solid

Molecular weight: 339.75

Ref: TM-T82735