CAS 5271-67-0

2-Thiophenecarbonyl chloride

Description:

2-Thiophenecarbonyl chloride, also known as thiophene-2-carbonyl chloride, is an organic compound characterized by the presence of a thiophene ring and an acyl chloride functional group. Its molecular structure features a five-membered aromatic ring containing sulfur, which contributes to its unique chemical properties. This compound is typically a colorless to pale yellow liquid with a pungent odor, indicative of the reactive acyl chloride group. It is known for its reactivity, particularly in acylation reactions, where it can react with various nucleophiles, including alcohols and amines, to form corresponding esters and amides. Due to the presence of the carbonyl and chloride functionalities, 2-thiophenecarbonyl chloride is sensitive to moisture and should be handled under anhydrous conditions. It is utilized in organic synthesis, particularly in the preparation of thiophene derivatives and other complex molecules in pharmaceutical and agrochemical research. Safety precautions are essential when handling this compound, as it can be corrosive and irritating to the skin and respiratory system.

Formula: C₅H₃ClOS

InChI: InChI=1S/C5H3ClOS/c6-5(7)4-2-1-3-8-4/h1-3H

InChI key: InChIKey=QIQITDHWZYEEPA-UHFFFAOYSA-N

SMILES: C(Cl)(=O)C1=CC=CS1

Synonyms:

• 2-(Chlorocarbonyl)thiophene
• 2-(Chloroformyl)thiophene
• 2-Thenoyl chloride
• 2-Thienoyl Chloride
• 2-Thienylcarbonyl Chloride
• 2-Thienylcarbonylchlorid
• 2-Thiophencarbonyl chloride
• 2-Thiophenecarboxylic acid chloride
• 2-Thiophenecarboxylic chloride
• 2-Thiopheneformyl chloride
• 2-Thiophenzoyl Chloride
• 4-[(3,3-Dimethyl-3,4-Dihydroisoquinolin-1-Yl)Amino]Benzenesulfonamide
• 7-Cyanoheptyl thiophene-2-carboxylate
• Akos 92490
• Akos Bbs-00003924
• Chlorure de 2-thienylcarbonyle
• Cloruro De 2-Tienilcarbonilo
• Thenoyl chloride
• Thiophen-2-ylcarbonyl chloride
• Thiophene-2-Carboxylic Acid Chloride
• Thiophene-2-carbonyl chloride
• α-Thenoyl chloride

2-Thenoyl Chloride

CAS: 5271-67-0

Formula: C₅H₃ClOS

Purity: >99.0%(T)

Color and Shape: Colorless to Brown clear liquid

Molecular weight: 146.59

Ref: 3B-T0177

Thiophene-2-carbonyl chloride, 98%

CAS: 5271-67-0

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₅H₃ClOS

Purity: 98%

Color and Shape: Clear colorless to pale yellow or brown or green, Liquid

Molecular weight: 146.6

Ref: 02-A14641

Thiophene-2-carbonyl chloride

CAS: 5271-67-0

Formula: C₅H₃ClOS

Purity: 95%

Color and Shape: Liquid

Molecular weight: 146.5947

Ref: IN-DA003B9U

Thiophene-2-carbonyl chloride

CAS: 5271-67-0

Thiophene-2-carbonyl chloride

Formula: C₅H₃ClOS

Purity: 98%

Color and Shape: clear. light yellow liquid

Molecular weight: 146.59g/mol

Ref: 54-OR23195

2-Thiophenecarbonyl chloride

CAS: 5271-67-0

Formula: C₅H₃ClOS

Purity: 95%

Color and Shape: Liquid

Molecular weight: 146.59

Ref: 10-F099110

2-Thiophenecarbonyl Chloride

Controlled Product

CAS: 5271-67-0

Applications 2-Thiophenecarbonyl Chloride is used in the synthesis of substituted pyridines as selective and highly effective GPR119 agonists. It is also seen in the preparation of diuretics.
References Wu, Y. et al.: Bioorg. Med. Chem. Lett., 20, 2577 (2010); Plattner, J. et al.: J. Med. Chem., 27, 1016 (1984)

Formula: C₅H₃ClOS

Color and Shape: Neat

Molecular weight: 146.59

Ref: TR-T368090