CAS 52712-76-2

Bunazosin hydrochloride

Description:

Bunazosin hydrochloride is a selective alpha-1 adrenergic antagonist primarily used in the treatment of hypertension and benign prostatic hyperplasia. It functions by blocking alpha-1 receptors, leading to vasodilation and a subsequent decrease in blood pressure. The compound is typically presented as a white to off-white crystalline powder, which is soluble in water and exhibits a moderate stability profile under standard conditions. Its molecular structure includes a piperidine ring, contributing to its pharmacological activity. Bunazosin hydrochloride is administered orally, and its pharmacokinetics involve absorption, distribution, metabolism, and excretion processes that are essential for its therapeutic efficacy. Side effects may include dizziness, headache, and orthostatic hypotension, which are common with alpha-blockers. As with any medication, it is crucial to consider contraindications and potential interactions with other drugs. Overall, Bunazosin hydrochloride represents a valuable option in managing specific cardiovascular and urological conditions.

Formula: C₁₉H₂₇N₅O₃·ClH

InChI: InChI=1S/C19H27N5O3.ClH/c1-4-6-17(25)23-7-5-8-24(10-9-23)19-21-14-12-16(27-3)15(26-2)11-13(14)18(20)22-19;/h11-12H,4-10H2,1-3H3,(H2,20,21,22);1H

InChI key: InChIKey=NBGBEUITCPENLJ-UHFFFAOYSA-N

SMILES: NC=1C2=C(N=C(N1)N3CCN(C(CCC)=O)CCC3)C=C(OC)C(OC)=C2.Cl

Synonyms:

• 1-(4-(4-Imino-6,7-dimethoxy-3,4-dihydroquinazolin-2-yl)-1,4-diazepan-1-yl)butan-1-one hydrochloride
• 1-Butanone, 1-[4-(4-amino-6,7-dimethoxy-2-quinazolinyl)hexahydro-1H-1,4-diazepin-1-yl]-, hydrochloride (1:1)
• 1-[4-(4-Amino-6,7-Dimethoxyquinazolin-2-Yl)-1,4-Diazepan-1-Yl]Butan-1-One
• 1-[4-(4-Amino-6,7-Dimethoxyquinazolin-2-Yl)-1,4-Diazepan-1-Yl]Butan-1-One Hydrochloride (1:1)
• 1-[4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-1,4-diazepan-1-yl]butan-1-one hydrochloride
• 1H-1,4-Diazepine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)hexahydro-4-(1-oxobutyl)-, monohydrochloride
• DDQ (pharmaceutical)
• Detantol
• E 643
• DDQ

1-[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)-1,4-diazepan-1-yl]butan-1-one hydrochloride

CAS: 52712-76-2

Formula: C₁₉H₂₈ClN₅O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 409.9103

Ref: IN-DA00I9FF

Bunazosin Hydrochloride

CAS: 52712-76-2

Bunazosin Hydrochloride

Purity: ≥98%

Molecular weight: 409.91g/mol

Ref: 54-BUP06786

Bunazosin hydrochloride

CAS: 52712-76-2

Formula: C₁₉H₂₈ClN₅O₃

Molecular weight: 409.91

Ref: 7W-GP6923

Bunazosin Hydrochloride

Controlled Product

CAS: 52712-76-2

Applications Bunazosin Hydrochloride is an α-1 adrenergic receptor antagonist that acts as an anti-cancer and anti-glaucoma drug.
References Daisy, P. et al.: Asian. J. Pharm. Clin. Res., 5, 149 (2012); Sakanaka, K. et al.: Biol. Pharm. Bull., 31, 1590 (2008);

Formula: C₁₉H₂₈ClN₅O₃

Color and Shape: White To Off-White

Molecular weight: 409.91

Ref: TR-B689585

Bunazosin Hydrochloride

CAS: 52712-76-2

Bunazosin Hydrochloride (E 1015) is an alpha(1)-adrenoceptor antagonist used as a systemic antihypertensive and an ocular hypotensive drug.

Formula: C₁₉H₂₈ClN₅O₃

Purity: 99.12%

Color and Shape: Solid

Molecular weight: 409.91

Ref: TM-T26923