CAS 52794-97-5

Carubicin hydrochloride

Description:

Carubicin hydrochloride, with the CAS number 52794-97-5, is an anthracycline antibiotic that is primarily derived from the fermentation of certain species of Streptomyces. It exhibits potent antitumor activity, making it a subject of interest in cancer treatment research. The compound functions by intercalating into DNA, thereby inhibiting the synthesis of nucleic acids and disrupting the replication process in rapidly dividing cells. Carubicin hydrochloride is characterized by its ability to generate free radicals, which can further contribute to its cytotoxic effects on cancer cells. It is typically administered intravenously and may be used in combination with other chemotherapeutic agents to enhance therapeutic efficacy. Like other anthracyclines, it is associated with potential side effects, including cardiotoxicity, which necessitates careful monitoring during treatment. The compound's solubility and stability are influenced by its hydrochloride form, which enhances its bioavailability. Overall, Carubicin hydrochloride represents a significant compound in the field of oncology, with ongoing research aimed at optimizing its use and minimizing adverse effects.

Formula: C₂₆H₂₇NO₁₀·ClH

InChI: InChI=1S/C26H27NO10.ClH/c1-9-21(30)13(27)6-16(36-9)37-15-8-26(35,10(2)28)7-12-18(15)25(34)20-19(23(12)32)22(31)11-4-3-5-14(29)17(11)24(20)33;/h3-5,9,13,15-16,21,29-30,32,34-35H,6-8,27H2,1-2H3;1H/t9-,13-,15-,16-,21+,26-;/m0./s1

InChI key: InChIKey=WYVYEIZFAUXWKW-SHUUXQFMSA-N

SMILES: O([C@@H]1C2=C(C(O)=C3C(=C2O)C(=O)C=4C(C3=O)=CC=CC4O)C[C@](C(C)=O)(O)C1)[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5.Cl

Synonyms:

• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-, hydrochloride (1:1), (8S,10S)-
• Carubicin hydrochloride
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-, hydrochloride, (8S,10S)-
• 5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-, hydrochloride, (8S-cis)-
• Carminomycin hydrochloride

4-Demethyl Daunorubicin Hydrochloride (Carubicin HCl)

CAS: 52794-97-5

Formula: C₂₆H₂₇NO₁₀·HCl

Molecular weight: 513.50 36.46

Ref: 4Z-D-4825

Karminomycin Hydrochloride

CAS: 52794-97-5

Applications Karminomycin Hydrochloride is an antibiotic that potently kills human tumor cells and their multidrug resistant variants. Highly active quinone-containing anticancer drugs. A new anthracycline antineoplastic antibiotic.
References Tevyashova, A. N., et al.: J. Antibiot., 57, 143 (2004); Bachur, N. R., et al.: Cancer Res., 38, 1745 (1978); Brazhnikova, M. G., et al.: J. Antibiot., 27, 254 (1974)

Formula: C₂₆H₂₇NO₁₀·HCl

Color and Shape: Neat

Molecular weight: 549.954

Ref: TR-K139710

Karminomycin HCl

CAS: 52794-97-5

Karminomycin HCl is an analog of carminomycin, which is a cytotoxic antibiotic. It inhibits the growth of tumor cells by inhibiting the production of epidermal growth factor, which is necessary for cell proliferation. Karminomycin HCl has been shown to inhibit the growth of tumors in mice with subcutaneous tumors and has demonstrated potent antitumor activity against sarcoma 180 cancer cells in vitro. This drug also inhibits the accumulation of cytosolic calcium, which may be due to its ability to bind to metal hydroxides. Karminomycin HCl has been shown to inhibit cardiac muscle contractions in rats and can be used as a treatment for congestive heart failure.

Formula: C₂₆H₂₈ClNO₁₀

Purity: Min. 95%

Molecular weight: 549.95 g/mol

Ref: 3D-FK166302

4-Demethyl Daunorubicin Hydrochloride

CAS: 52794-97-5

Formula: C₂₆H₂₇NO₁₀HCl

Molecular weight: 513.50 : 36.5

Ref: ST-EA-CP-D104008

Carubicin hydrochloride

CAS: 52794-97-5

Carubicin HCl is an anthracycline antineoplastic antibiotic. Through intercalates into DNA and interacts with topoisomerase II, Carubicin inhibits DNA replication and repair and RNA and protein synthesis.

Formula: C₂₆H₂₈ClNO₁₀

Color and Shape: Solid

Molecular weight: 549.95

Ref: TM-T26953