CAS 52805-46-6

3-Hydroxy-4-methoxybenzonitrile

Description:

3-Hydroxy-4-methoxybenzonitrile, with the CAS number 52805-46-6, is an organic compound characterized by the presence of a hydroxyl group (-OH) and a methoxy group (-OCH3) attached to a benzene ring, along with a nitrile group (-C≡N). This compound typically appears as a solid at room temperature and is soluble in polar organic solvents. Its molecular structure suggests it may exhibit both acidic and basic properties due to the hydroxyl group, which can participate in hydrogen bonding. The presence of the nitrile group contributes to its potential reactivity, making it useful in various chemical syntheses. Additionally, the methoxy group can influence the compound's electronic properties, affecting its reactivity and interaction with other molecules. 3-Hydroxy-4-methoxybenzonitrile may find applications in pharmaceuticals, agrochemicals, or as an intermediate in organic synthesis, owing to its functional groups that can undergo further chemical transformations. Safety data should be consulted for handling and usage, as with any chemical substance.

Formula: C₈H₇NO₂

InChI: InChI=1S/C8H7NO2/c1-11-8-3-2-6(5-9)4-7(8)10/h2-4,10H,1H3

InChI key: InChIKey=ASQHIJLQYYFUDN-UHFFFAOYSA-N

SMILES: C(#N)C1=CC(O)=C(OC)C=C1

Synonyms:

• 2-Methoxy-5-cyanophenol
• 3-Hydroxy-4-Methoxybenzonitrile (Isovanillonitrile)
• 5-Cyano-2-methoxyphenol
• Benzonitrile, 3-hydroxy-4-methoxy-
• Isovanillonitrile
• 3-Hydroxy-4-methoxybenzonitrile

3-Hydroxy-4-methoxybenzonitrile

CAS: 52805-46-6

Formula: C₈H₇NO₂

Purity: 97%

Color and Shape: Solid

Molecular weight: 149.1467

Ref: IN-DA003JJP

Gefitinib Impurity (3-Hydroxy-4-methoxybenzonitrile)

CAS: 52805-46-6

Formula: C₈H₇NO₂

Color and Shape: Off-White Solid

Molecular weight: 149.15

Ref: 4Z-G-2316

3-Hydroxy-4-methoxy benzonitrile

CAS: 52805-46-6

3-Hydroxy-4-methoxy benzonitrile

Purity: 98%

Molecular weight: 149.15g/mol

Ref: 54-OR345595

3-Hydroxy-4-methoxybenzonitrile

CAS: 52805-46-6

The synthesis of 3-hydroxy-4-methoxybenzonitrile (3HMB) is achieved by the reaction of bromoethane, chloride and methylating agents in hydrochloric acid. This process yields a mixture of products that are separated by fractional distillation. The reaction yield of 3HMB is dependent on the amount of epidermal growth factor (EGF), which can be increased by adding morpholine to the reaction mixture. 3HMB is also a growth factor that has been shown to stimulate cell proliferation and differentiation in vitro. It binds to the epidermal growth factor receptor and stimulates EGF-dependent signal transduction pathways, leading to activation of protein kinase C and mitogen-activated protein kinase.

Formula: C₈H₇NO₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 149.15 g/mol

Ref: 3D-FH29690

3-Hydroxy-4-methoxybenzonitrile

CAS: 52805-46-6

Formula: C₈H₇NO₂

Purity: 98%

Color and Shape: Grey powder

Molecular weight: 149.149

Ref: 10-F078354

Apremilast Impurity 19

CAS: 52805-46-6

Formula: C₈H₇NO₂

Molecular weight: 149.15

Ref: ST-EA-CP-A77036