CAS 52806-53-8

Hydroxyflutamide

Description:

Hydroxyflutamide is a non-steroidal anti-androgen that is primarily used in the treatment of prostate cancer. It acts by inhibiting the action of androgens, such as testosterone, on androgen receptors, thereby slowing the growth of hormone-sensitive tumors. The chemical formula of hydroxyflutamide is C11H12F3N3O3, and it features a trifluoromethyl group, which enhances its potency and selectivity. Hydroxyflutamide is typically administered orally and is known for its relatively high bioavailability. Its mechanism of action involves competitive inhibition of androgen binding to receptors, leading to a decrease in androgen-mediated cellular processes. The substance is characterized by its moderate solubility in organic solvents and limited solubility in water. Side effects may include gastrointestinal disturbances, liver function alterations, and potential impacts on lipid metabolism. Due to its specific action on androgen receptors, hydroxyflutamide is an important therapeutic agent in managing prostate cancer, particularly in cases where hormonal manipulation is required.

Formula: C₁₁H₁₁F₃N₂O₄

InChI: InChI=1S/C11H11F3N2O4/c1-10(2,18)9(17)15-6-3-4-8(16(19)20)7(5-6)11(12,13)14/h3-5,18H,1-2H3,(H,15,17)

InChI key: InChIKey=YPQLFJODEKMJEF-UHFFFAOYSA-N

SMILES: C(F)(F)(F)C1=C(N(=O)=O)C=CC(NC(C(C)(C)O)=O)=C1

Synonyms:

• 2-Hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)propanamide
• 2-Hydroxyflutamide
• Hydroxyniphtholide
• Propanamide, 2-hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-
• Sch 16423
• alpha,alpha,alpha-Trifluoro-2-methyl-4'-nitro-m-lactotoluidide
• α,α,α-Trifluoro-2-methyl-4′-nitro-m-lactotoluidide

Propanamide, 2-​hydroxy-​2-​methyl-​N-​[4-​nitro-​3-​(trifluoromethyl)​phenyl]​-

CAS: 52806-53-8

Formula: C₁₁H₁₁F₃N₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 292.2112

Ref: IN-DA003HDP

Hydroxy Flutamide

CAS: 52806-53-8

Formula: C₁₁H₁₁F₃N₂O₄

Color and Shape: Pale Yellow Solid

Molecular weight: 292.22

Ref: 4Z-F-502

2-hydroxy Flutamide

CAS: 52806-53-8

2-hydroxy Flutamide

Purity: ≥98%

Molecular weight: 292.21g/mol

Ref: 54-BUP15555

2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide (2-Hydroxyflutamide)

Controlled Product

CAS: 52806-53-8

Formula: C₁₁H₁₁F₃N₂O₄

Color and Shape: Neat

Molecular weight: 292.21

Ref: 86-MM0161.01

Hydroxyflutamide

CAS: 52806-53-8

Formula: C₁₁H₁₁F₃N₂O₄

Purity: >98.0%(HPLC)

Color and Shape: White to Brown powder to crystal

Molecular weight: 292.21

Ref: 3B-H1600

2-hydroxy Flutamide

CAS: 52806-53-8

2-hydroxy Flutamide is competitive inhibition of androgen receptor (AR) for the treatment of prostate cancer

Formula: C₁₁H₁₁F₃N₂O₄

Purity: 99.45% - 99.82%

Color and Shape: Solid

Molecular weight: 292.21

Ref: TM-T7690

Hydroxyflutamide

CAS: 52806-53-8

Formula: C₁₁H₁₁F₃N₂O₄

Purity: ≥ 97.5%

Color and Shape: White to bege or pale brown powder or crystals

Molecular weight: 292.21

Ref: 7W-GP8298

2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide

CAS: 52806-53-8

2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide

Purity: 97%

Color and Shape: Solid

Molecular weight: 292.21g/mol

Ref: 54-PC1193

Hydroxy Flutamide

Controlled Product

CAS: 52806-53-8

Applications The active metabolite of the widely used non-steroidal antagonist Flutamide (F598850). Shown to be an antianhydrogen.
References Katchen, B., et al.: J. Clin. Endocrinol. Metab., 41, 373 (1975), Fau, D., et al.: J. Pharmacol. Exp. Ther., 269, 954 (1994), Anzenbacher, P., et al.: Drug Metab. Dispos., 30, 100 (2002), Norlin, M., et al.: J. Lipid Res., 43, 721 (2002),

Formula: C₁₁H₁₁F₃N₂O₄

Color and Shape: Off White Solid

Molecular weight: 292.21

Ref: TR-H942475

Hydroxy flutamide

CAS: 52806-53-8

Hydroxyflutamide is an anti-androgen drug that belongs to the group of nonsteroidal anti-androgens. It has been shown to bind to the androgen receptor with high affinity and inhibit the growth of cancer cells in vitro. Hydroxyflutamide also has a strong antitumor response in vivo, which is due to its ability to inhibit cellular proliferation by binding to DNA polymerase during replication. The drug may also have some activity as an antineoplastic agent because it inhibits the growth of prostate cancer cells. However, hydroxyflutamide has never been tested on humans or animals, so its effects are unknown.

Formula: C₁₁H₁₁F₃N₂O₄

Purity: Min. 98 Area-%

Color and Shape: Yellow Powder

Molecular weight: 292.21 g/mol

Ref: 3D-FH24016

Hydroxyflutamide

CAS: 52806-53-8

Purity: 98%

Molecular weight: 292.2139893

Ref: 10-F791312

Hydroxy Flutamide

CAS: 52806-53-8

Formula: C₁₁H₁₁F₃N₂O₄

Molecular weight: 292.21

Ref: ST-EA-CP-F22007