CAS 52806-53-8: Hydroxyflutamide
Description:Hydroxyflutamide is a non-steroidal anti-androgen that is primarily used in the treatment of prostate cancer. It acts by inhibiting the action of androgens, such as testosterone, on androgen receptors, thereby slowing the growth of hormone-sensitive tumors. The chemical formula of hydroxyflutamide is C11H12F3N3O3, and it features a trifluoromethyl group, which enhances its potency and selectivity. Hydroxyflutamide is typically administered orally and is known for its relatively high bioavailability. Its mechanism of action involves competitive inhibition of androgen binding to receptors, leading to a decrease in androgen-mediated cellular processes. The substance is characterized by its moderate solubility in organic solvents and limited solubility in water. Side effects may include gastrointestinal disturbances, liver function alterations, and potential impacts on lipid metabolism. Due to its specific action on androgen receptors, hydroxyflutamide is an important therapeutic agent in managing prostate cancer, particularly in cases where hormonal manipulation is required.
Formula:C11H11F3N2O4
InChI:InChI=1S/C11H11F3N2O4/c1-10(2,18)9(17)15-6-3-4-8(16(19)20)7(5-6)11(12,13)14/h3-5,18H,1-2H3,(H,15,17)
InChI key:InChIKey=YPQLFJODEKMJEF-UHFFFAOYSA-N
SMILES:O=C(NC1=CC=C(C(=C1)C(F)(F)F)N(=O)=O)C(O)(C)C
- Synonyms:
- 2-Hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)propanamide
- 2-Hydroxyflutamide
- Hydroxyniphtholide
- Propanamide, 2-hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-
- Sch 16423
- alpha,alpha,alpha-Trifluoro-2-methyl-4'-nitro-m-lactotoluidide
- α,α,α-Trifluoro-2-methyl-4′-nitro-m-lactotoluidide