CAS 52809-07-1

Quisqualic acid

Description:

Quisqualic acid is a naturally occurring amino acid derivative that functions primarily as a selective agonist for certain glutamate receptors, particularly the metabotropic glutamate receptor subtype. It is derived from the seeds of the Quisqualis indica plant and is known for its role in neurobiology, particularly in studies related to synaptic transmission and neuropharmacology. The compound is characterized by its ability to induce excitatory neurotransmission, making it a valuable tool in research on neuronal signaling pathways. Quisqualic acid is soluble in water and exhibits a relatively low molecular weight, which facilitates its use in various biochemical assays. Its structural features include multiple functional groups that contribute to its receptor-binding properties. Additionally, due to its neuroactive nature, quisqualic acid has been investigated for its potential implications in understanding neurological disorders and developing therapeutic strategies. However, like many neuroactive compounds, it requires careful handling and consideration of its effects on biological systems.

Formula: C₅H₇N₃O₅

InChI: InChI=1/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1

InChI key: InChIKey=ASNFTDCKZKHJSW-REOHCLBHSA-N

SMILES: C([C@@H](C(O)=O)N)N1C(=O)NC(=O)O1

Synonyms:

• (2S)-2-Amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid
• (2S)-2-Amino-3-(3-hydroxy-5-oxo-2,5-dihydro-1,2,4-oxadiazol-2-yl)propanoic acid
• (2S)-2-Amino-3-(5-hydroxy-3-oxo-2,3-dihydro-1,2,4-oxadiazol-2-yl)propanoic acid
• (αS)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid
• 1,2,4-Oxadiazolidine-2-propanoic acid, alpha-amino-3,5-dioxo-, (S)-
• 1,2,4-Oxadiazolidine-2-propanoic acid, α-amino-3,5-dioxo-, (S)-
• 1,2,4-Oxadiazolidine-2-propanoic acid, α-amino-3,5-dioxo-, (αS)-
• 3-(3,5-Dioxo-1,2,4-Oxadiazolidin-2-Yl)Alanine
• 3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine
• <span class="text-smallcaps">L</span>-Quisqualic acid
• Quisqualate
• Quisqualinic acid
• S-Quisqualic acid
• L-Quisqualic acid
• Quisqualic acid
• (αS)-α-Amino-3,5-dioxotetrahydro-1,2,4-oxadiazole-2-propionic acid
• BETA-[3,5-DIOXO-1,2,4-OXADIAZOLIDIN-2-YL]-L-ALANINE
• L-(+)-a-Amino-3,5-Dioxo-1,2,4-oxadiazolidine-2-pro
• 1,2,4-Oxadiazolidine-2-propanoicacid, a-aMino-3,5-dioxo-, (aS)-
• BETA-(3,5-DIOXO-1,2,4-OXADIZOLIDIN-2-YL)-L-ALANINE
• β-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine, 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine
• Quisqualic acid,β-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine, 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine
• L-(+)-A-AMINO-3,5-DIOXO-1,2,4-OXADIAZOLIDINE-2-PROPANOIC ACID
• (S)-2-aMino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid
• (S)-2-Amino-3-(3,5-dioxotetrahydro-1,2,4-oxadiazole-2-yl)propionic acid
• β-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)-l-alanine
• L-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic Acid

(+)-Quisqualic acid, 99+%

CAS: 52809-07-1

Quisqualic acid is used to differentiate between mGluR-1 and mGluR-4. L-Quisqualic acid is an activator of GluR. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The origina

Formula: C₅H₇N₃O₅

Purity: 99+%

Molecular weight: 189.13

Ref: 02-J61591

Quisqualinic acid

CAS: 52809-07-1

Formula: C₅H₇N₃O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 189.1262

Ref: IN-DA003540

(S)-2-Amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid

CAS: 52809-07-1

(S)-2-Amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid

Purity: 98%

Molecular weight: 189.13g/mol

Ref: 54-OR1073798

L-Quisqualic acid

CAS: 52809-07-1

Formula: C₅H₇N₃O₅

Molecular weight: 189.13

Ref: 7W-GE0005

L-Quisqualic Acid

CAS: 52809-07-1

Formula: C₅H₇N₃O₅

Purity: 95%~99%

Molecular weight: 189.127

Ref: BP-BP2042

(+)-Quisqualic Acid

Controlled Product

CAS: 52809-07-1

Applications An amino acid that is able to function as an agonist at multiple excitatory amino acid receptor substrates in the central nervous system. It also has high affinity for the kainate, AMPA and the metabotropic receptors. Inhibits the Ca2+/Cl-dependent glutamic acid uptake system in brain synaptic plasma membrane preparations.
References Honore, T., et al.: J. Neurochem., 38, 173 (1982), Schoepp, D., et al.: J. Neurochem., 50, 1605 (1988), Recasens, M., et al.: Neurochem. Int., 13, 463 (1988), Subasinghe, N., et al.: J. Med. Chem., 35, 4602 (1992)

Formula: C₅H₇N₃O₅

Color and Shape: Neat

Molecular weight: 189.13

Ref: TR-Q825000