CAS 529-35-1

5,6,7,8-Tetrahydro-1-naphthol

Description:

5,6,7,8-Tetrahydro-1-naphthol, with the CAS number 529-35-1, is an organic compound characterized by its bicyclic structure, which consists of a naphthalene ring system that has undergone partial hydrogenation. This results in a saturated compound with a hydroxyl (-OH) group attached to one of the carbon atoms in the naphthalene framework. The compound is typically a colorless to pale yellow liquid or solid, depending on its purity and temperature. It is known for its aromatic properties and is soluble in organic solvents, while being less soluble in water due to its hydrophobic nature. 5,6,7,8-Tetrahydro-1-naphthol is utilized in various applications, including as an intermediate in organic synthesis and in the production of pharmaceuticals and fragrances. Its chemical reactivity is influenced by the presence of the hydroxyl group, which can participate in hydrogen bonding and other chemical reactions. Safety data indicates that it should be handled with care, as it may pose health risks if ingested or inhaled.

Formula: C₁₀H₁₂O

InChI: InChI=1S/C10H12O/c11-10-7-3-5-8-4-1-2-6-9(8)10/h3,5,7,11H,1-2,4,6H2

InChI key: InChIKey=SCWNNOCLLOHZIG-UHFFFAOYSA-N

SMILES: OC1=C2C(=CC=C1)CCCC2

Synonyms:

• 1,2,3,4-Tetrahydro-5-hydroxynaphthalene
• 1,2,3,4-Tetrahydro-5-naphthol
• 1,2,3,4-Tetrahydronaphthalen-5-ol
• 1-Hydroxy-5,6,7,8-tetrahydronaphthalene
• 1-Naphthalenol, 5,6,7,8-tetrahydro-
• 1-Naphthol, 5,6,7,8-tetrahydro-
• 5,6,7,8-Tetrahydro-1-hydroxynaphthalene
• 5,6,7,8-Tetrahydro-1-naphthalenol
• 5,6,7,8-Tetrahydro-alpha-naphthol
• 5,6,7,8-Tetrahydro-α-naphthol
• 5,6,7,8-Tetrahydronaphthalen-1-Ol
• 5,6,7,8-Tetrahydronaphthol
• 5-Hydroxytetralin
• Nsc 28822
• Tetrahydro-alpha-naphthol
• Tetrahydro-α-naphthol
• Tetralin-5-ol

5,6,7,8-Tetrahydro-1-naphthol

CAS: 529-35-1

Formula: C₁₀H₁₂O

Purity: >98.0%(GC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 148.21

Ref: 3B-T2816

5,6,7,8-Tetrahydro-1-naphthol, 99%

CAS: 529-35-1

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₀H₁₂O

Purity: 99%

Color and Shape: White to cream to dark brown to pale cream to gray, Crystals or powder or crystalline powder or fused solid

Molecular weight: 148.21

Ref: 02-L02416

5,6,7,8-Tetrahydro-1-naphthol

CAS: 529-35-1

Formula: C₁₀H₁₂O

Purity: 98%

Color and Shape: Solid

Molecular weight: 148.2017

Ref: IN-DA003M96

5,6,7,8-Tetrahydro-1-naphthol

CAS: 529-35-1

Formula: C₁₀H₁₂O

Molecular weight: 148.21

Ref: 7W-GL8471

5,6,7,8-Tetrahydronaphthalen-1-ol

CAS: 529-35-1

5,6,7,8-Tetrahydronaphthalen-1-ol

Purity: 98%

Molecular weight: 148.20g/mol

Ref: 54-OR914367

5,6,7,8-Tetrahydronaphthalen-1-ol

CAS: 529-35-1

Formula: C₁₀H₁₂O

Purity: 95%

Color and Shape: Solid

Molecular weight: 148.205

Ref: 10-F242836

5,6,7,8-Tetrahydro-1-naphthol

CAS: 529-35-1

5,6,7,8-Tetrahydro-1-naphthol is a natural compound that belongs to the group of diazonium compounds. It reacts with an alkanoic acid and a hydrochloric acid in the presence of a diazo compound to form an alkylating product. This product can be used as a precursor for the synthesis of other organic compounds. The reaction mechanism has been studied using rat liver microsomes. 5,6,7,8-Tetrahydro-1-naphthol can react with dopamine in human liver samples to form 1-hydroxyindole and phenylhydroxyl radicals (a reactive oxygen species). 5,6,7,8-Tetrahydro-1-naphthol also reacts with soybean lipoxygenase to produce an alkyl radical intermediate that can react with molecular oxygen to form peroxides.

Formula: C₁₀H₁₂O

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 148.2 g/mol

Ref: 3D-FT00059

5,6,7,8-Tetrahydro-1-naphthalenol

Controlled Product

CAS: 529-35-1

Applications 5,6,7,8-Tetrahydro-1-naphthalenol was used as a reagent in the synthesis of phosphonamidate and phosphonodiamidate prodrugs of adefovir and tenofovir which are used in the treatment of HIV infections. Also used in the synthesis of tetrahydronaphthalene-1-ol derivatives which were found to be promising potent antitumor agents.
References Pertusati, F., et al.: Eur. J. Med. Chem., 78, 259 (2014); Dong, Y., et al.: Bioorg. Med. Chem. Lett., 19, 6289 (2009);

Formula: C₁₀H₁₂O

Color and Shape: Neat

Molecular weight: 148.2

Ref: TR-T294265