CAS 52906-92-0

Motilin

Description:

Motilin is a peptide hormone primarily produced in the small intestine, specifically by the M cells in the duodenum and jejunum. It plays a crucial role in regulating gastrointestinal motility, stimulating the contraction of the smooth muscles in the stomach and intestines, thereby promoting gastric emptying and facilitating digestion. The chemical structure of motilin consists of a sequence of amino acids, typically comprising 22 residues, which is essential for its biological activity. It acts on specific motilin receptors located in the gastrointestinal tract. Motilin levels fluctuate in response to fasting and feeding, with increased levels observed during fasting, which helps prepare the digestive system for the intake of food. In clinical settings, motilin and its analogs have been studied for their potential therapeutic applications in treating gastrointestinal disorders, such as gastroparesis. The CAS number 52906-92-0 uniquely identifies this substance in chemical databases, aiding in its recognition and study within the scientific community.

Formula: C₁₂₀H₁₈₈N₃₄O₃₅S

InChI: InChI=1/C120H188N34O35S/c1-9-64(6)97(152-114(184)86-31-22-53-154(86)117(187)96(63(4)5)151-99(169)70(123)56-66-23-12-10-13-24-66)115(185)150-84(57-67-25-14-11-15-26-67)113(183)153-98(65(7)155)116(186)149-83(58-68-32-34-69(156)35-33-68)101(171)135-60-91(161)136-75(39-45-93(163)164)105(175)147-82(55-62(2)3)111(181)145-77(37-43-88(125)158)106(176)140-73(29-20-51-132-119(128)129)103(173)146-80(48-54-190-8)110(180)142-76(36-42-87(124)157)107(177)144-79(41-47-95(167)168)108(178)139-72(28-17-19-50-122)102(172)143-78(40-46-94(165)166)109(179)141-74(30-21-52-133-120(130)131)104(174)148-85(59-90(127)160)112(182)138-71(27-16-18-49-121)100(170)134-61-92(162)137-81(118(188)189)38-44-89(126)159/h10-15,23-26,32-35,62-65,70-86,96-98,155-156H,9,16-22,27-31,36-61,121-123H2,1-8H3,(H2,124,157)(H2,125,158)(H2,126,159)(H2,127,160)(H,134,170)(H,135,171)(H,136,161)(H,137,162)(H,138,182)(H,139,178)(H,140,176)(H,141,179)(H,142,180)(H,143,172)(H,144,177)(H,145,181)(H,146,173)(H,147,175)(H,148,174)(H,149,186)(H,150,185)(H,151,169)(H,152,184)(H,153,183)(H,163,164)(H,165,166)(H,167,168)(H,188,189)(H4,128,129,132)(H4,130,131,133)

SMILES: CCC(C)C(C(=NC(Cc1ccccc1)C(=NC(C(C)O)C(=NC(Cc1ccc(cc1)O)C(=NCC(=NC(CCC(=O)O)C(=NC(CC(C)C)C(=NC(CCC(=N)O)C(=NC(CCCNC(=N)N)C(=NC(CCSC)C(=NC(CCC(=N)O)C(=NC(CCC(=O)O)C(=NC(CCCCN)C(=NC(CCC(=O)O)C(=NC(CCCNC(=N)N)C(=NC(CC(=N)O)C(=NC(CCCCN)C(=NCC(=NC(CCC(=N)O)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C(C1CCCN1C(=O)C(C(C)C)N=C(C(Cc1ccccc1)N)O)O

Synonyms:

• Motilin
• Motilin (human, porcine)
• H-Phe-Val-Pro-Ile-Phe-Thr-Tyr-Gly-Glu-Leu-Gln-Arg-Met-Gln-Glu-Lys-Glu-Arg-Asn-Lys-Gly-Gln-OH
• MeSH ID: D009037
• GASTRIC MOTOR STIMULATORY PEPTIDE, PORCINE
• FVPIFTYGELQRMQEKERNKGQ
• Motilin, porcine, ≥97% (HPLC)
• Gastricmotorstimulatorypeptide
• MOTILIN, PORCINE
• Motilin (26-47), human, porcine
• MOTILIN PORCINE ≥97%

Motilin (26-47), human, porcine

CAS: 52906-92-0

Motilin (26-47) binds Motilin receptors in hamster cells; Ki=2.3 nM, EC50=0.3 nM; same for humans, pigs.

Formula: C₁₂₀H₁₈₈N₃₄O₃₅S

Purity: 98%

Color and Shape: Solid

Molecular weight: 2699.07

Ref: TM-TP1425

Motilin (human, porcine)

CAS: 52906-92-0

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool

Formula: C₁₂₀H₁₈₈N₃₄O₃₅S

Molecular weight: 2,699.1 g/mol

Ref: 3D-PP50504

Motilin (Human, Porcine)

CAS: 52906-92-0

Motilin is a peptide that is used as a research tool in the fields of cell biology, pharmacology, and biochemistry. It is an activator of the motilin receptor and has been shown to bind to ligand-gated ion channels. Motilin has also been shown to inhibit the activity of high-voltage activated calcium channels.

Formula: C₁₂₀H₁₈₈N₃₄O₃₅S

Purity: Min. 95%

Molecular weight: 2,699 g/mol

Ref: 3D-PML-4147-V