CAS 5291-32-7

2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one

Description:

2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one, with CAS number 5291-32-7, is a bicyclic compound featuring a nitrogen atom within its structure, characteristic of azabicyclic compounds. This substance contains both hydroxymethyl and methoxymethyl functional groups, which contribute to its reactivity and potential applications in organic synthesis. The bicyclic framework provides a rigid structure that can influence the compound's physical properties, such as solubility and melting point. The presence of the ketone functional group indicates potential for reactivity in nucleophilic addition reactions. Additionally, the compound may exhibit biological activity due to its structural features, making it of interest in medicinal chemistry. Its unique combination of functional groups and bicyclic structure may also allow for various modifications, leading to derivatives with tailored properties for specific applications. As with many organic compounds, safety data and handling precautions should be considered when working with this substance in a laboratory setting.

Formula: C₁₀H₁₇NO₃

InChI: InChI=1S/C10H17NO3/c1-14-7-10(6-12)9(13)8-2-4-11(10)5-3-8/h8,12H,2-7H2,1H3

InChI key: InChIKey=BGBNULCRKBVAKL-UHFFFAOYSA-N

SMILES: C(OC)C1(CO)N2CCC(C1=O)CC2

Synonyms:

• 2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one
• APR 246
• PRIMA 1Met
• 3-Quinuclidinone, 2-(hydroxymethyl)-2-(methoxymethyl)-
• 1-Azabicyclo[2.2.2]octan-3-one, 2-(hydroxymethyl)-2-(methoxymethyl)-
• PRIMA-1
• 2-(Hydroxymethyl)-2-(methoxymethyl)-3-quinuclidinone
• APR-246 (PRIMA-1MET)
• 2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one
• PRIMA-1MET(APR-246)
• MET
• APR246;APR 246

2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one

CAS: 5291-32-7

Formula: C₁₀H₁₇NO₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 199.2469

Ref: IN-DA0037PA

2-(Hydroxymethyl)-2-(Methoxymethyl)Quinuclidin-3-One

CAS: 5291-32-7

2-(Hydroxymethyl)-2-(Methoxymethyl)Quinuclidin-3-One

Purity: 97%

Molecular weight: 199.25g/mol

Ref: 54-OR1024145

Eprenetapopt

CAS: 5291-32-7

Eprenetapopt

Purity: ≥98%

Molecular weight: 199.25g/mol

Ref: 54-BUP10151

PRIMA-1MET

CAS: 5291-32-7

Formula: C₁₀H₁₇NO₃

Purity: >95.0%(GC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 199.25

Ref: 3B-E1608

Eprenetapopt

CAS: 5291-32-7

Eprenetapopt (PRIMA-1Met) restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells.

Formula: C₁₀H₁₇NO₃

Purity: 98.75% - 99.57%

Color and Shape: Solid

Molecular weight: 199.25

Ref: TM-T4414

2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one

CAS: 5291-32-7

Purity: 97%

Molecular weight: 199.25

Ref: 10-F862447

2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one

Controlled Product

CAS: 5291-32-7

Applications 2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one is a small molecule that has shown promising preclinical activity in various cancer types. 2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one shows antitumor activity in multiple myeloma by induction of p73 and Noxa.
References Saha, M.N., et. al.: Mol. Cancer Ther., 12, 2331 (2013); Aryee, D.N.T., et. al.: Brit. J. Cancer, 109, 2696 (2013)

Formula: C₁₀H₁₇NO₃

Color and Shape: White Solid

Molecular weight: 199.25

Ref: TR-H947100

APR 246

CAS: 5291-32-7

APR 246 is a methyltransferase inhibitor that has been shown to be effective against tumor cells. It acts by inhibiting the activity of DNA methyltransferases, which are enzymes that catalyze the transfer of methyl groups to DNA. This inhibition inhibits the process of epigenetic regulation and leads to apoptosis. APR 246 has also been shown to inhibit receptor activity, cell adhesion, and cell proliferation in synergistic cells. The compound is an antagonist for mutant p53 and has been found to induce caspase-independent cell death in cancer cells.

Formula: C₁₀H₁₇NO₃

Purity: Min. 95%

Molecular weight: 199.25 g/mol

Ref: 3D-BA176962