CAS 52934-83-5: Nanaomycin A

Description: Nanaomycin A is a natural product belonging to the class of compounds known as anthracyclines, which are characterized by their complex polycyclic structures. It is derived from the fermentation of the bacterium *Streptomyces* species. Nanaomycin A exhibits notable biological activity, particularly as an antitumor agent, and has been studied for its potential in cancer therapy due to its ability to intercalate DNA and inhibit topoisomerase II, leading to disruption of DNA replication and transcription. The compound is known for its unique structural features, including a sugar moiety and a chromophore that contribute to its biological efficacy. Additionally, Nanaomycin A has shown promise in overcoming drug resistance in certain cancer cell lines, making it a subject of interest in pharmaceutical research. Its chemical properties, such as solubility and stability, are influenced by its molecular structure, which can affect its bioavailability and therapeutic potential. Overall, Nanaomycin A represents a significant area of study in the development of novel anticancer agents.

Formula: C₁₆H₁₄O₆

InChI: InChI=1S/C16H14O6/c1-7-13-10(5-8(22-7)6-12(18)19)15(20)9-3-2-4-11(17)14(9)16(13)21/h2-4,7-8,17H,5-6H2,1H3,(H,18,19)/t7-,8+/m0/s1

InChI key: InChIKey=ZCJHPTKRISJQTN-JGVFFNPUSA-N

SMILES: O=C(O)CC1OC(C=2C(=O)C=3C(O)=CC=CC3C(=O)C2C1)C

Synonyms:

• (1S,3R)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic acid
• (9-hydroxy-1-methyl-5,10-dioxo-3,4,5,10-tetrahydro-1H-benzo[g]isochromen-3-yl)acetic acid
• 1H-Naphtho[2,3-c]pyran-3-acetic acid, 3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-, (1S,3R)-
• 1H-Naphtho[2,3-c]pyran-3-acetic acid, 3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-, (1S-trans)-
• Antibiotic OS 3966A
• Nanafrocin
• Nanomycin A
• [(1S,3R)-9-hydroxy-1-methyl-5,10-dioxo-3,4,5,10-tetrahydro-1H-benzo[g]isochromen-3-yl]acetic acid
• Nanaomycin A

Nanaomycin A

CAS: 52934-83-5

Nanaomycin A, a quinone antibiotic, reactivates cancer suppressor genes and inhibits DNMT3B (IC50=500nM).

• Formula: C₁₆H₁₄O₆
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 302.28

Nanaomycin A

CAS: 52934-83-5

Nanaomycin A is a natural product that inhibits the growth of cells by inhibiting cell …

• Formula: C₁₆H₁₄O₆
• Purity: Min. 95%
• Molecular weight: 302.28 g/mol