CAS 52942-31-1

Etoperidone

Description:

Etoperidone is an atypical antipsychotic agent primarily used in the treatment of schizophrenia and other psychiatric disorders. It belongs to the class of compounds known as phenylpiperidines and exhibits a unique pharmacological profile, acting as a serotonin and dopamine receptor antagonist. The chemical structure of etoperidone includes a piperidine ring, which contributes to its ability to modulate neurotransmitter activity in the brain. Its mechanism of action involves the blockade of dopamine D2 receptors and serotonin 5-HT2A receptors, which helps alleviate symptoms of psychosis. Etoperidone is characterized by its moderate affinity for these receptors, which may result in a lower incidence of extrapyramidal side effects compared to traditional antipsychotics. Additionally, it has been noted for its potential anxiolytic and antidepressant effects. The substance is typically administered orally and is metabolized in the liver, with its pharmacokinetics influenced by various factors, including age and liver function. As with any medication, monitoring for side effects and interactions is essential during treatment.

Formula: C₁₉H₂₈ClN₅O

InChI: InChI=1S/C19H28ClN5O/c1-3-18-21-25(19(26)24(18)4-2)10-6-9-22-11-13-23(14-12-22)17-8-5-7-16(20)15-17/h5,7-8,15H,3-4,6,9-14H2,1-2H3

InChI key: InChIKey=IZBNNCFOBMGTQX-UHFFFAOYSA-N

SMILES: C(C)N1C(CC)=NN(CCCN2CCN(CC2)C3=CC(Cl)=CC=C3)C1=O

Synonyms:

• Etoran
• 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one
• Etonin
• Axiomin
• 260-942-5
• 2-{3-[4-(3-Chlorophenyl)piperazin-1-yl]propyl}-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one
• 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-4,5-diethyl-2,4-dihydro-3H-1,2,4-triazol-3-one
• Depracer
• 1,2,4-Triazol-3-one, 2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-4,5-diethyl-2,4-dihydro-
• Etoperidon
• Etoperidone

Etoperidone

CAS: 52942-31-1

Etoperidone is an antidepressant that acts as an orally active reuptake inhibitor for serotonin (serotonin) and noradrenaline (nor-adrenaline). It demonstrates specific binding affinities (Kd) for several receptors: 36 nM at the 5-HT2 receptor, 38 nM at the α1-adrenergic receptor (α1-adrenergic receptor), 85 nM at the 5-HT1A receptor, and 570 nM at the α2-adrenergic receptor (α2-adrenergic receptor).

Formula: C₁₉H₂₈ClN₅O

Color and Shape: Solid

Molecular weight: 377.91

Ref: TM-T201838