CAS 529488-28-6

GENZ-644282

Description:

GENZ-644282, with the CAS number 529488-28-6, is a chemical compound that has been studied primarily for its potential therapeutic applications, particularly in the field of oncology. It is classified as a small molecule inhibitor, specifically targeting certain kinases involved in cancer cell proliferation and survival. The compound exhibits a specific mechanism of action that disrupts signaling pathways critical for tumor growth, making it a candidate for cancer treatment. In terms of its physical and chemical properties, GENZ-644282 is characterized by its molecular structure, which includes various functional groups that contribute to its biological activity. The compound's solubility, stability, and bioavailability are important factors that influence its efficacy and safety profile in clinical settings. As with many investigational drugs, ongoing research is essential to fully understand its pharmacokinetics, pharmacodynamics, and potential side effects. Overall, GENZ-644282 represents a promising avenue in the development of targeted cancer therapies.

Synonyms:

• Genz-644282
• 2,3-Dimethoxy-12-[2-(methylamino)ethyl]benzo[c][1,3]benzodioxolo[5,6-h][1,6]naphthyridin-13(12H)-one
• 8,9-dimethoxy-2,3-methylenedioxy-5-[2-(N-methylamino)ethyl]-5H-dibenzo[c,h]1,6-naphthyridin-6-one

Genz644282

CAS: 529488-28-6

Formula: C₂₂H₂₁N₃O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 407.4192

Ref: IN-DA00DB66

2,3-Dimethoxy-12-(2-(Methylamino)Ethyl)-[1,3]Dioxolo[4',5':4,5]Benzo[1,2-H]Benzo[c][1,6]Naphthyridin-13(12H)-One

CAS: 529488-28-6

2,3-Dimethoxy-12-(2-(Methylamino)Ethyl)-[1,3]Dioxolo[4',5':4,5]Benzo[1,2-H]Benzo[c][1,6]Naphthyridin-13(12H)-One

Purity: 99%

Molecular weight: 407.42g/mol

Ref: 54-OR1024048

Genz-644282

CAS: 529488-28-6

Genz-644282

Purity: ≥95%

Molecular weight: 407.42g/mol

Ref: 54-BUP03258

Genz-644282

CAS: 529488-28-6

Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.

Formula: C₂₂H₂₁N₃O₅

Purity: 97.49%

Color and Shape: Solid

Molecular weight: 407.42

Ref: TM-T7187

GENZ-644282

CAS: 529488-28-6

GENZ-644282 is a drug transporter that is structurally similar to the natural compound quinoline. It has been shown to have significant cytotoxicity in vitro against cancer cells, and it has been shown to be effective in vivo against colorectal adenocarcinoma. This compound can act as a prodrug for other drugs, such as doxorubicin and paclitaxel. The mechanism of action of GENZ-644282 is not yet fully understood, but it may be due to its ability to inhibit the function of the p-glycoprotein protein in tumor xenografts.
GENZ-644282 also inhibits the function of ABCG2, an ATP binding cassette transporter protein that transports lipophilic molecules from the cell membrane into the cell interior. This inhibition leads to accumulation of lipophilic substances in the extracellular space and increased permeability of tumor cells, which causes cell death by apoptosis or necrosis.

Formula: C₂₂H₂₁N₃O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 407.42 g/mol

Ref: 3D-EWA48828

GENZ-644282

Controlled Product

CAS: 529488-28-6

Applications GENZ-644282 is used in the synthesis of ARC-111 analogs in the improvement of the antitumor activity of the parent compound.
References Zhou, W. et al.: Med. Chem. Res., 22, 278 (2013); Zhou, W. et al.: Int. J. Mol. Sci., 13, 1161 (2012);

Formula: C₂₂H₂₁N₃O₅

Color and Shape: Neat

Molecular weight: 407.42

Ref: TR-G367760