CAS 53-02-1

Tetrahydrocortisol

Description:

Tetrahydrocortisol, with the CAS number 53-02-1, is a steroid hormone that is a metabolite of cortisol, a key glucocorticoid produced by the adrenal cortex. It is characterized by its structure, which includes a steroid nucleus with four fused carbon rings, and it possesses hydroxyl functional groups that contribute to its biological activity. Tetrahydrocortisol is primarily involved in the metabolism of carbohydrates, proteins, and fats, and it plays a role in the regulation of inflammation and immune responses. This compound is typically found in the human body as a product of cortisol metabolism and can be measured in urine as an indicator of adrenal function. Its solubility in organic solvents and limited solubility in water are notable physical properties. Tetrahydrocortisol is also of interest in clinical settings, particularly in the context of stress response and various endocrine disorders. Understanding its characteristics is essential for research in endocrinology and pharmacology.

Formula: C₂₁H₃₄O₅

InChI: InChI=1S/C21H34O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-16,18,22-24,26H,3-11H2,1-2H3/t12-,13-,14+,15+,16+,18-,19+,20+,21+/m1/s1

InChI key: InChIKey=AODPIQQILQLWGS-GXBDJPPSSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])([C@@H](O)C1)[H])[H])(CC[C@@]2(C(CO)=O)O)[H]

Synonyms:

• (3Alpha,5Beta,11Beta)-3,11,17,21-Tetrahydroxypregnan-20-One
• (3α,5β,11β)-3,11,17,21-Tetrahydroxypregnan-20-one
• 3-alpha,11-beta,17,21-Tetrahydroxy-5-beta-pregnan-20-one
• 3alpha,11beta,17,21-Tetrahydroxy-5beta-pregnan-20-one
• 3alpha,11beta,17,21-Tetrahydroxypregnan-20-one
• 3alpha,5beta-Tetrahydrocortisol
• 3α,11β,17,21-Tetrahydroxy-5β-pregnan-20-one
• 3α,11β,17,21-Tetrol-5β-pregnan-20-one
• 3α,11β,17α,21-Tetrahydroxy-5β-pregnan-20-one
• 5-beta-Pregnan-20-one, 3-alpha,11-beta,17,21-tetrahydroxy-
• 5-beta-Tetrahydrocortisol
• 5beta-Pregnan-20-one, 3alpha,11beta,17,21-tetrahydroxy- (8CI)
• 5beta-Tetrahydrocortisol
• 5β-Pregnan-20-one, 3α,11β,17,21-tetrahydroxy-
• 5β-Tetrahydrocortisol
• Ba 2682
• Cortisol, tetrahydro-
• Nsc 57431
• Pregnan-20-one, 3,11,17,21-tetrahydroxy-, (3alpha,5beta,11beta)- (9CI)
• Pregnan-20-one, 3,11,17,21-tetrahydroxy-, (3α,5β,11β)-
• THF (hormone)
• Tetrahydro F
• Tetrahydrocompound F
• Tetrahydrocortisol
• Tetrahydrohydrocortisone
• Urocortisol

Tetrahydrocortisol

CAS: 53-02-1

Tetrahydrocortisol (Tetrahydrohydrocortisone) is a metabolite of neurosteroids and cortisol, a GABAA receptor antagonist, lowering intraocular pressure.

Formula: C₂₁H₃₄O₅

Purity: 99.95%

Color and Shape: Solid

Molecular weight: 366.49

Ref: TM-T17057

Pregnan-20-one, 3,11,17,21-tetrahydroxy-, (3a,5b,11b)-

CAS: 53-02-1

Formula: C₂₁H₃₄O₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 366.4917

Ref: IN-DA01CCLM

Tetrahydrocortisol

CAS: 53-02-1

Tetrahydrocortisol

Purity: ≥98%

Molecular weight: 366.49g/mol

Ref: 54-BUP21160

Tetrahydrohydrocortisone (Tetrahydrocortisol)

CAS: 53-02-1

Formula: C₂₁H₃₄O₅

Molecular weight: 366.50

Ref: 4Z-H-103026

Tetrahydrocortisol

Controlled Product

CAS: 53-02-1

Applications Tetrahydrocortisol is excreted in large amounts in premenopausal patients with early breast cancer. Tetrahydrocortisol has been found to be produced by lymphocytes in both normal and cancer bearing patients however, the concentration of Tetrahydrocortisol has increased in patients with cancer.
References Kodama, M., et. al.: J. Natl. Cancer I., 54, 1275 (1975); Klein, A., et. al.: Metabolism, 27, 731 (1978)

Formula: C₂₁H₃₄O₅

Color and Shape: Off-White

Molecular weight: 366.49

Ref: TR-T293370

5β-Tetrahydrocortisol-d5

Controlled Product

CAS: 53-02-1

Formula: C₂₁D₅H₂₉O₅

Color and Shape: Neat

Molecular weight: 371.522

Ref: TR-T293379

3a,5b-Tetrahydrocortisol

Controlled Product

CAS: 53-02-1

3a,5b-Tetrahydrocortisol is a drug that belongs to the class of corticosteroids. It is used in clinical research as a model system for cortisol and other steroids, as well as in studies on infectious diseases. 3a,5b-Tetrahydrocortisol can be used to measure cortisol concentrations in biological samples such as saliva or urine. This drug also has an effect on body mass index and glomerular filtration rate. The analytical method used for measuring 3a,5b-tetrahydrocortisol is liquid chromatography-mass spectrometry (LC-MS/MS).

Formula: C₂₁H₃₄O₅

Purity: (%) Min. 95%

Color and Shape: Powder

Molecular weight: 366.49 g/mol

Ref: 3D-FT145628