CAS 53-05-4

Tetrahydrocortisone

Description:

Tetrahydrocortisone, also known as 11-dehydrocorticosterone, is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties. It is derived from cortisol and is characterized by its steroidal structure, which includes four fused carbon rings. The compound is typically a white to off-white crystalline powder, and it is soluble in organic solvents like ethanol and chloroform but has limited solubility in water. Tetrahydrocortisone is primarily used in medical applications to treat conditions such as allergies, autoimmune disorders, and inflammation. Its mechanism of action involves the modulation of gene expression, leading to reduced production of inflammatory mediators. The substance is also known for its potential side effects, which can include weight gain, hypertension, and increased susceptibility to infections when used long-term. Due to its pharmacological properties, tetrahydrocortisone is classified under controlled substances in some jurisdictions, necessitating careful regulation and monitoring in clinical settings.

Formula: C₂₁H₃₂O₅

InChI: InChI=1/C21H32O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-15,18,22-23,26H,3-11H2,1-2H3

InChI key: InChIKey=SYGWGHVTLUBCEM-ZIZPXRJBSA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])(C(=O)C1)[H])[H])(CC[C@@]2(C(CO)=O)O)[H]

Synonyms:

• (3Alpha,5Beta)-3,17,21-Trihydroxypregnane-11,20-Dione
• (3α,5β)-3,17,21-Trihydroxypregnane-11,20-dione
• 3,17,21-Trihydroxypregnane-11,20-Dione
• 3alpha,17,21-Trihydroxy-5-beta-pregnane-11,20-dione
• 3alpha,17,21-Trihydroxypregnane-11,20-dione
• 3α,17,21-Trihydroxy-5β-pregnan-11,20-dione
• 3α,17,21-Trihydroxy-5β-pregnane-11,20-dione
• 3α,17α,21-Trihydroxy-5β-pregnane-11,20-dione
• 3α,5β-Tetrahydrocortisone
• 5beta-Pregnane-11,20-dione, 3alpha,17,21-trihydroxy- (8CI)
• 5β-Pregnan-3α,17α,21-triol-11,20-dione
• 5β-Pregnane-11,20-dione, 3α,17,21-trihydroxy-
• 5β-Pregnane-3α,17α,21-triol-11,20-dione
• 5β-Tetrahydrocortisone
• Ba 2681
• Cortisone, tetrahydro-
• Nsc 76984
• Pregnane-11,20-dione, 3,17,21-trihydroxy-, (3alpha,5beta)- (9CI)
• Pregnane-11,20-dione, 3,17,21-trihydroxy-, (3α,5β)-
• THE [Steroid]
• Tetrahydro E
• Tetrahydrocompound E
• Tetrahydrocortisone
• Urocortisone
• 5-Pregnan-3a,17a,21-triol-11,20-dione-d5
• Pregnane-11,20-dione, 3,17,21-trihydroxy-, (3.alpha.,5.beta.)-
• 3-A-17,21-TRIHYDROXY-5-BETA-PREGNANE-11,20-DIONE
• 3β,5β-Tetrahydro Cortisone
• 3α,17,21-Trihydroxy-5β-pregnan-
• 11,20-dione
• 3,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-11-one

3α,17,21-trihydroxy-5-β-pregnane-11,20-dione

CAS: 53-05-4

Formula: C₂₁H₃₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 364.4758

Ref: IN-DA00DDEX

Tetrahydrocortisone

CAS: 53-05-4

Formula: C₂₁H₃₂O₅

Molecular weight: 364.48

Ref: 4Z-C-491010

Tetrahydrocortisone

CAS: 53-05-4

Tetrahydrocortisone

Purity: ≥95%

Molecular weight: 364.48g/mol

Ref: 54-BUP22091

Tetrahydrocortisone

CAS: 53-05-4

Tetrahydrocortisone, the inactive metabolite of cortisone, is a product of cortisone's enzymatic reduction, an indicator of cortisol metabolism.

Formula: C₂₁H₃₂O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 364.48

Ref: TM-T19576

Tetrahydro Cortisone

Controlled Product

CAS: 53-05-4

Applications A normal mammalian metabolite of Cortisone (C696500).
References Schneider, et al.: J. Biol. Chem., 183, 365 (1950), Barkemeyer, et al.: Appl. Microbiol., 8, 237 (1960),

Formula: C₂₁H₃₂O₅

Color and Shape: Neat

Molecular weight: 364.48

Ref: TR-T293375

Tetrahydro Cortisone-d6

Controlled Product

CAS: 53-05-4

Applications Labelled Tetrahydrocortisone (T293375). A normal mammalian metabolite of Cortisone (C696500).
References Schneider, et al.: J. Biol. Chem., 183, 365 (1950), Barkemeyer, et al.: Appl. Microbiol., 8, 237 (1960),

Formula: C₂₁H₂₆D₆O₅

Color and Shape: Neat

Molecular weight: 370.51

Ref: TR-T293377

Tetrahydrocortisone

Controlled Product

CAS: 53-05-4

Cortisol is a steroid hormone that regulates the metabolism of carbohydrates, proteins, and fats. Cortisol is also involved in immune function and stress response. Cortisol levels are typically highest in the morning and lowest at night. Cortisol can be used to diagnose adrenal gland disorders, such as Addison's disease or Cushing's syndrome. The diagnosis of these diseases is based on the measurement of cortisol levels in blood, saliva, or urine. Cortisol can also be measured to assess the severity of an illness or the body's response to a particular treatment.

Formula: C₂₁H₃₂O₅

Purity: Min. 98%

Color and Shape: Powder

Molecular weight: 364.48 g/mol

Ref: 3D-FT65182