CAS 53-33-8

Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-16-methyl-, (6α,11β,16α)-

Description:

Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-16-methyl-, commonly known as Fluocinolone acetonide, is a synthetic corticosteroid with anti-inflammatory and immunosuppressive properties. It is characterized by its steroidal structure, which includes a fluorine atom at the 6-position and multiple hydroxyl groups that enhance its biological activity. This compound is typically used in dermatological formulations to treat various skin conditions, such as eczema and psoriasis, due to its ability to reduce inflammation and suppress immune responses. The presence of the 1,4-diene system contributes to its stability and potency. Fluocinolone acetonide is usually administered topically, and its pharmacokinetics can vary based on the formulation and application method. As with other corticosteroids, it is important to use this compound under medical supervision to minimize potential side effects, including skin atrophy and systemic absorption. Overall, Fluocinolone acetonide is a valuable therapeutic agent in the management of inflammatory skin disorders.

Formula: C₂₂H₂₉FO₅

InChI: InChI=1/C22H29FO5/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-20(15,2)19(13)17(26)9-21(14,3)22(11,28)18(27)10-24/h4-5,7,11,13-14,16-17,19,24,26,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20+,21+,22+/m1/s1

InChI key: InChIKey=MKPDWECBUAZOHP-AFYJWTTESA-N

SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C([C@@H](F)C3)=CC(=O)C=C4)([C@@H](O)C1)[H])[H])(C[C@@H](C)[C@@]2(C(CO)=O)O)[H]

Synonyms:

• (6α,11β,16α)-6-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
• 16α-Methyl-6α-fluoroprednisolone
• 6α-Fluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione
• 6α-Fluoro-16α-methylprednisolone
• Cortiden
• Parametasona
• Paramethason
• Paramethasone
• Pregna-1,4-diene-3,20-dione, 6α-fluoro-11β,17,21-trihydroxy-16-methyl-
• Pregna-1,4-diene-3,20-dione, 6α-fluoro-11β,17,21-trihydroxy-16α-methyl-
• Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-16-methyl-, (6α,11β,16α)-
• 6-alpha-fluoro-16-alpha-methylprednisolone
• 6-alpha-fluoro-11-beta,17-alpha,21-trihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione
• (6alpha,11beta,16alpha)-6-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
• Pregna-1,4-diene-3,20-dione, 6-fluoro-11,17,21-trihydroxy-16-methyl-, (6a,11b,16a)- (9CI)
• (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-17-glycoloyl-11,17-dihydroxy-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one
• Pregna-1,4-diene-3,20-dione, 6a-fluoro-11b,17,21-trihydroxy-16-methyl- (7CI)
• 1,4-PREGNADIEN-6-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE
• Pregna-1,4-diene-3,20-dione, 6a-fluoro-11b,17,21-trihydroxy-16a-methyl- (8CI)
• 6α-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
• (6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyethanoyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one

Paramethasone

CAS: 53-33-8

Parametasone is a glucocorticoid with the general properties of corticosteroids.

Formula: C₂₂H₂₉FO₅

Color and Shape: Solid

Molecular weight: 392.46

Ref: TM-T33883L

Paramethasone

CAS: 53-33-8

Formula: C₂₂H₂₉FO₅

Molecular weight: 392.47

Ref: 4Z-P-444004

Paramethasone

Controlled Product

CAS: 53-33-8

Applications Paramethasone, is a fluorinated glucocorticoid, having anti-inflammatory and immunosuppressant properties.
References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995), Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999), Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999);

Formula: C₂₂H₂₉FO₅

Color and Shape: White To Beige

Molecular weight: 392.46

Ref: TR-P191840

Paramethasone

Controlled Product

CAS: 53-33-8

Paramethasone is a nonsteroidal anti-inflammatory drug that is used in the treatment of inflammatory conditions such as rheumatoid arthritis, osteoarthritis, and other autoimmune disorders. Its mechanism of action is not fully understood but it is believed to act by suppressing the production of pro-inflammatory cytokines. Paramethasone has been shown to be effective against cervical cancer cells and alopecia areata. This drug also has toxic effects on liver cells at high doses. The toxicity of paramethasone has been studied in experimental models and humans; it appears to be less toxic than other steroids when given orally or systemically. The most common side effect with this drug is weight gain, which may be due to an increase in fat tissue.

Formula: C₂₂H₂₉FO₅

Purity: Min. 95%

Molecular weight: 392.46 g/mol

Ref: 3D-FP100930

Dexamethasone Impurity 23

CAS: 53-33-8

Formula: C₂₂H₂₉FO₅

Molecular weight: 392.47

Ref: ST-EA-CP-D17049