CAS 53-35-0
:6β-Hydroxycortisol
Description:
6β-Hydroxycortisol is a steroid hormone and a metabolite of cortisol, classified under the glucocorticoids. It is characterized by its hydroxyl group at the 6β position, which distinguishes it from other cortisol derivatives. This compound plays a role in the metabolism of cortisol and is involved in various physiological processes, including the regulation of inflammation and immune response. 6β-Hydroxycortisol is typically found in human urine and is often measured in clinical settings to assess adrenal function and cortisol metabolism. Its presence can indicate alterations in cortisol production, which may be relevant in conditions such as Cushing's syndrome or adrenal insufficiency. The substance is soluble in organic solvents and exhibits a relatively stable structure under physiological conditions. As a metabolite, it is important in understanding the pharmacokinetics of corticosteroids and their effects on the body. Overall, 6β-Hydroxycortisol serves as a significant biomarker in endocrinology and metabolic studies.
Formula:C21H30O6
InChI:InChI=1S/C21H30O6/c1-19-5-3-11(23)7-14(19)15(24)8-12-13-4-6-21(27,17(26)10-22)20(13,2)9-16(25)18(12)19/h7,12-13,15-16,18,22,24-25,27H,3-6,8-10H2,1-2H3/t12-,13-,15+,16-,18+,19-,20-,21-/m0/s1
InChI key:InChIKey=GNFTWPCIRXSCQF-UJXAPRPESA-N
SMILES:C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C([C@H](O)C3)=CC(=O)CC4)([C@@H](O)C1)[H])[H])(CC[C@@]2(C(CO)=O)O)[H]
Synonyms:- 6β-Hydroxycortisol
- Corticosterone, 6β,17-dihydroxy-
- (6β,11β)-6,11,17,21-Tetrahydroxypregn-4-ene-3,20-dione
- Pregn-4-ene-3,20-dione, 6,11,17,21-tetrahydroxy-, (6β,11β)-
- Pregn-4-ene-3,20-dione, 6β,11β,17,21-tetrahydroxy-
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Found 8 products.
6β-Hydroxyhydrocortisone (6β,11β,17,21-Tetrahydroxypregn-4-ene-3,20-dione)
CAS:Ketone-alcohols and ketone-aldehydes, nesoiFormula:C21H30O6Color and Shape:White PowderMolecular weight:378.20424Hydrocortisone EP Impurity D (6-β-Hydroxy Hydrocortisone)
CAS:Formula:C21H30O6Molecular weight:378.47Benzyl-2-acetamido-2-deoxy-4-O-β-D-galactofuranosyl-α-D-glucopyranoside
CAS:Benzyl-2-acetamido-2-deoxy-4-O-β-D-galactofuranosyl-α-D-glucopyranosidePurity:≥95%6β,11β,17,21-Tetrahydroxypregn-4-ene-3,20-dione (6β-Hydroxyhydrocortisone)
CAS:Controlled ProductFormula:C21H30O6Color and Shape:NeatMolecular weight:378.4596β-Hydroxy Cortisol
CAS:Controlled Product<p>Impurity Hydrocortisone EP Impurity D<br>Applications 6β-Hydroxy Cortisol (Hydrocortisone EP Impurity D) is a metabolite of Cortisol.<br>References Dossing, M., et al.: Eur. J. Clin. Pharmacol., 25, 215 ( 1983), Gorski, J., et al.: Biochem. Pharmacol., 47, 1643 (1994), Raucy, J., et al.: Drug Metab. Dispos., 31, 533 (2003), Pal, D., et al.: Life Sci., 78, 2131 (2006),<br></p>Formula:C21H30O6Color and Shape:WhiteMolecular weight:378.4596b-Hydroxy cortisol
CAS:Controlled ProductCortisol is a steroid hormone that is synthesized in the adrenal gland and has a broad range of biological effects. It is an endogenous anti-inflammatory agent and immunosuppressant that can inhibit the production of pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF-α) and interleukin 1β (IL-1β). Cortisol also has inhibitory properties on intestinal motility and has been shown to be effective in reducing bowel disease activity. In some cases, cortisol may cause high blood pressure, hyperglycemia, and hypercorticism. Cortisol levels are typically lower at night than during the day due to its circadian rhythm. The concentration–time curve for cortisol can be determined using LC-MS/MS methods. Cortisol is metabolized by cytochrome P450 enzymes into 6b-hydroxycortisol.Formula:C21H30O6Purity:Min. 95 Area-%Color and Shape:PowderMolecular weight:378.46 g/mol
