CAS 53-79-2

Puromycin

Description:

Puromycin is an antibiotic and a potent inhibitor of protein synthesis, primarily derived from the bacterium *Streptomyces alboniger*. It is characterized by its ability to mimic the structure of aminoacyl-tRNA, allowing it to bind to the ribosome and disrupt the elongation phase of translation in both prokaryotic and eukaryotic cells. This mechanism leads to premature termination of polypeptide chains, effectively halting protein synthesis. Puromycin is often used in molecular biology as a selection agent for cells that have been genetically modified to express a puromycin resistance gene. Its chemical structure includes an amino acid moiety linked to a purine-like core, contributing to its biological activity. While it is effective in research and therapeutic applications, puromycin can also exhibit cytotoxic effects, necessitating careful handling and usage in laboratory settings. Its CAS number, 53-79-2, is a unique identifier that facilitates its recognition in chemical databases and regulatory documents.

Formula: C₂₂H₂₉N₇O₅

InChI: InChI=1S/C22H29N7O5/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32)/t14-,15+,16+,18+,22+/m0/s1

InChI key: InChIKey=RXWNCPJZOCPEPQ-NVWDDTSBSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(N(C)C)N=CN3)O[C@H](CO)[C@H]1NC([C@H](CC4=CC=C(OC)C=C4)N)=O

Synonyms:

• (S)-3'-((2-Amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3'-deoxy-N,N-dimethyladenosine
• 3'-(L-alpha-Amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosine
• 3'-deoxy-N,N-dimethyl-3'-[(O-methyl-L-tyrosyl)amino]adenosine
• 3'-deoxy-N,N-dimethyl-3'-[(O-methyl-L-tyrosyl)amino]adenosine dihydrochloride
• 3'-deoxy-N,N-dimethyl-3'-[(O-methyltyrosyl)amino]adenosine
• 3123L
• 3′-[[(2S)-2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3′-deoxy-N,N-dimethyladenosine
• 6-Dimethylamino-9-(3'-(p-methoxy-L-phenylalanylamino)-beta-D-ribofuranosyl)-purine
• Achromycin
• Achromycin (purine derivative)
• Adenosine, 3'-(((2S)-2-amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3'-deoxy-N,N-dimethyl-
• Adenosine, 3'-((2-amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3'-deoxy-N,N-dimethyl-, (S)-
• Adenosine, 3'-(alpha-amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyl-, L-
• Adenosine, 3′-(α-amino-p-methoxyhydrocinnamamido)-3′-deoxy-N,N-dimethyl-, <span class="text-smallcaps">L</span>-
• Cl 13,900
• Cl 16536
• Nsc-3055
• P-638
• Puromicina
• Puromicina [INN-Spanish]
• Puromycin [USAN:INN:BAN]
• Puromycine
• Puromycine [INN-French]
• Puromycinum
• Puromycinum [INN-Latin]
• Stillomycin
• Stylomycin
• Unii-4A6Zs6Q2Cl
• β-<span class="text-smallcaps">D</smallcap>-Ribofuranoside, 6-(dimethylamino)-9H-purine-9 3-deoxy-3-[(4-methoxy-<smallcap>L</span>-phenylalanyl)amino]-
• 1-MM

Puromycin

CAS: 53-79-2

Puromycin

Purity: ≥98%

Molecular weight: 471.51g/mol

Ref: 54-BUP22188

Puromycin

CAS: 53-79-2

Formula: C₂₂H₂₉N₇O₅

Purity: ≥ 98.0%

Color and Shape: White powder

Molecular weight: 471.51

Ref: 7W-GA8451

Puromycin

CAS: 53-79-2

Puromycin (NSC-3055) is an antibiotic protein synthesis inhibitor.

Formula: C₂₂H₂₉N₇O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 471.51

Ref: TM-T19978

Puromycin-D3

CAS: 53-79-2

Puromycin-D3 is a deuterium-labeled antibiotic, which is synthetically derived from the bacterium *Streptomyces alboniger*, with three hydrogen atoms replaced by deuterium. Its mode of action involves the inhibition of protein synthesis by mimicking the aminoacyl end of tRNA, causing premature chain termination during translation on ribosomes. This mechanism specifically targets growing peptides in cells, making it a valuable tool for studying protein synthesis.

Formula: C₂₂H₂₆D₃N₇O₅

Purity: Min. 95%

Molecular weight: 474.53 g/mol

Ref: 3D-AAA05379