CAS 53-95-2

N-Hydroxy-2-(acetylamino)fluorene

Description:

N-Hydroxy-2-(acetylamino)fluorene, with the CAS number 53-95-2, is an organic compound that features a hydroxylamine functional group attached to a fluorene structure. This compound is characterized by its molecular formula, which includes both acetyl and amino functional groups, contributing to its reactivity and potential applications in organic synthesis and medicinal chemistry. It typically appears as a solid at room temperature and is soluble in organic solvents. The presence of the hydroxylamine group makes it a useful intermediate in various chemical reactions, including those involving nucleophilic substitutions and the formation of azo compounds. Additionally, N-hydroxy compounds are often studied for their biological activities, including potential roles in drug development and as intermediates in the synthesis of more complex molecules. Safety considerations should be taken into account when handling this compound, as it may pose health risks if not managed properly. Overall, N-Hydroxy-2-(acetylamino)fluorene is a significant compound in the field of organic chemistry with various applications.

Formula: C₁₅H₁₃NO₂

InChI: InChI=1S/C15H13NO2/c1-10(17)16(18)13-6-7-15-12(9-13)8-11-4-2-3-5-14(11)15/h2-7,9,18H,8H2,1H3

InChI key: InChIKey=SOKUIEGXJHVFDV-UHFFFAOYSA-N

SMILES: N(C(C)=O)(O)C=1C=C2C(C=3C(C2)=CC=CC3)=CC1

Synonyms:

• 2-(N-Hydroxyacetamido)fluorene
• Acetamide, N-9H-fluoren-2-yl-N-hydroxy-
• Acetamide, N-fluoren-2-yl-N-hydroxy-
• Acetohydroxamic acid, N-fluoren-2-yl-
• N-2-Fluorenyl-N-hydroxyacetamide
• N-2-Fluorenylacetohydroxamic acid
• N-Acetyl-N-2-fluorenylhydroxylamine
• N-Hydroxy-2-(acetylamino)fluorene
• N-Hydroxy-AAF
• N-Hydroxy-N-(2-fluorenyl)acetamide
• NSC 46522

N-9H-Fluoren-2-yl-N-hydroxy-acetamide

CAS: 53-95-2

N-9H-Fluoren-2-yl-N-hydroxyacetamide is a prodrug that is hydrolyzed in vivo to form 2-(2,6-dichloro-4-(p-nitrophenoxy)phenoxy)-N,N-dimethylethylene diamine (N,9H-diiodofluorene). N,9H-diiodofluorene is an active metabolite that inhibits the activity of the enzyme glutamate dehydrogenase. This inhibition leads to accumulation of ammonia and cell death. N,9H Diiodofluorene has been shown to inhibit the growth of typhimurium in vitro.

Formula: C₁₅H₁₃NO₂

Purity: Min. 95%

Molecular weight: 239.27 g/mol

Ref: 3D-AAA05395