CAS 530-62-1

1,1′-Carbonyldiimidazole

Description:

1,1′-Carbonyldiimidazole (CDI) is a versatile chemical compound widely used as a coupling agent in organic synthesis, particularly in peptide and ester formation. It features a symmetrical structure with two imidazole rings connected by a carbonyl group, which contributes to its reactivity. CDI is typically a white to off-white solid at room temperature and is soluble in organic solvents such as dichloromethane and dimethylformamide. Its reactivity stems from the carbonyl group, which can activate nucleophiles, making it effective for acylation reactions. CDI is known for its stability under ambient conditions but should be handled with care due to its potential to release imidazole upon hydrolysis, which can lead to unwanted side reactions in sensitive environments. Additionally, it is important to note that CDI can be hazardous, and appropriate safety measures should be taken when handling this compound, including the use of personal protective equipment and working in a well-ventilated area. Overall, CDI is a valuable reagent in synthetic organic chemistry, facilitating the formation of various chemical bonds.

Formula: C₇H₆N₄O

InChI: InChI=1S/C7H6N4O/c12-7(10-3-1-8-5-10)11-4-2-9-6-11/h1-6H

InChI key: InChIKey=PFKFTWBEEFSNDU-UHFFFAOYSA-N

SMILES: C(=O)(N1C=CN=C1)N2C=CN=C2

Synonyms:

• 1,1'-Carbonylbis-1H-imidazol
• 1,1'-Carbonylbis-1H-imidazole
• 1,1'-Carbonylbisimidazole
• 1,1'-Carbonyldiimidazole
• 1,1'-carbonilbis-1H-imidazol
• 1-(1H-Imidazol-1-ylcarbonyl)-1H-imidazole
• 1-(1H-Imidazole-1-carbonyl)-1H-imidazole
• Bis(1H-imidazol-1-yl)methanone
• Bis(imidazol-1-yl) ketone
• Bis(imidazol-1-yl)methanone
• Di-1H-imidazol-1-ylmethanone
• Diimidazol-1-yl ketone
• Imidazole, 1,1'-carbonyldi-
• Methanone, di-1H-imidazol-1-yl-
• N,N'-Carbonylbis(imidazole)
• N,N'-Carbonyldiimidazole
• Nsc 67203

1,1'-Carbonyldiimidazole [Coupling Agent for Peptides Synthesis]

CAS: 530-62-1

Formula: C₇H₆N₄O

Purity: >97.0%(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 162.15

Ref: 3B-C0119

1,1'-Carbonyldiimidazole, 97%

CAS: 530-62-1

Peptide coupling reagent1,1'-Carbonyldiimidazole acts as a coupling reagent and utilized for coupling of amino acids in order to prepare peptide in organic synthesis. It is also used in the preparation of beta-keto sulfones, sulfoxides and beta-enamino acid derivatives. It is used to convert alcohol

Formula: C₇H₆N₄O

Purity: 97%

Color and Shape: Crystals or powder or crystalline powder, White to cream

Molecular weight: 162.15

Ref: 02-A14688

1,1‘-Carbonyldiimidazole

CAS: 530-62-1

Formula: C₇H₆N₄O

Purity: 98%

Color and Shape: Solid

Molecular weight: 162.1487

Ref: IN-DA0032JR

N,N'-Carbonyldiimidazole

CAS: 530-62-1

N,N'-Carbonyldiimidazole is a biological cross-linking agent that has great application in mass spectrometry to detect the purity of compounds.

Formula: C₇H₆N₄O

Purity: 98%

Color and Shape: White Solid Crystalline

Molecular weight: 162.15

Ref: TM-T19945

N,N''-Carbonyldiimidazole

CAS: 530-62-1

Formula: C₇H₆N₄O

Purity: (Titration) ≥ 97.0%

Color and Shape: White, off-white or pale yellow powder or crystals

Molecular weight: 162.15

Ref: 7W-GE9348

1,1'-Carbonyldiimidazole

CAS: 530-62-1

Formula: C₇H₆N₄O

Color and Shape: White To Off-White Solid

Molecular weight: 162.15

Ref: 4Z-I-078006

1,1'-Carbonyldi(1H-imidazole)

CAS: 530-62-1

1,1'-Carbonyldi(1H-imidazole)

Formula: C₇H₆N₄O

Purity: 98%

Color and Shape: white powder

Molecular weight: 162.14874g/mol

Ref: 54-OR18334

1,1'-Carbonyldiimidazole-d6(N,N'-Carbonyldiimidazole)

CAS: 2363787-46-4, 530-62-1

Purity: 98 atom % D

Molecular weight: 168.2

Ref: 3U-D8187

N,N’-Carbonyldiimidazole

CAS: 530-62-1

Formula: C₇H₆N₄O

Purity: 98.0%

Color and Shape: Solid

Molecular weight: 162.152

Ref: 10-F003800

Rivaroxaban Impurity 1

CAS: 530-62-1

Formula: C₇H₆N₄O

Molecular weight: 162.2

Ref: ST-EA-CP-R17075

N,N'-Carbonyldiimidazole

CAS: 530-62-1

CDI is a coupling agent used mainly for amide and ester formation, but also thioesters, ureas and carbamates. CDI is used in a one-pot procedure, where an acyl imidazolide is formed first upon activation of the carboxylic acid with CDI. The amine or alcohol is then added, and it readily reacts with the active intermediate and the product is generated. CDI does not require the presence of base. The addition to the CDI reaction mixture of carbon dioxide or weakly acid compounds such as imidazole hydrochloride, was reported to increase the reaction rates. CDI can be used in large-scale synthesis thanks to its affordable cost, its availability, and the ease of removal of the by-products during the workup, which are carbon dioxide and imidazole. CDI can be employed as a replacement of the poisonous phosgene, as an imidazolium transfer reagent and in the synthesis of lead sequestering agents.

Formula: C₇H₆N₄O

Color and Shape: Off-White Powder

Molecular weight: 162.15 g/mol

Ref: 3D-FC02706

1,1'-Carbonyldiimidazole (>90%)

CAS: 530-62-1

Stability Hygroscopic, Moisture Sensitive
Applications Used in the synthesis of peptides. Contains up to 10% imidazole.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Pierschbacher, M., et al.: Nature, 309, 30 (1984),

Formula: C₇H₆N₄O

Purity: >90%

Color and Shape: White To Off-White

Molecular weight: 162.15

Ref: TR-C177005

N,N-Carbonyldiimidazole (CDI) extrapure AR, 98%

CAS: 530-62-1

Formula: C₇H₆N₄O

Purity: min. 98%

Color and Shape: Off- white, Crystalline powder, Clear

Molecular weight: 162.15

Ref: SR-67852