CAS 53003-10-4

Salinomycin

Description:

Salinomycin is a polyether ionophore antibiotic primarily derived from the fermentation of Streptomyces albus. It is characterized by its ability to transport monovalent cations, particularly sodium and potassium ions, across biological membranes, which disrupts cellular ion homeostasis. Salinomycin exhibits potent antimicrobial activity, particularly against certain Gram-positive bacteria and protozoa, making it valuable in veterinary medicine, especially in poultry for the prevention of coccidiosis. Additionally, it has garnered attention in cancer research due to its potential to selectively target and eliminate cancer stem cells, thereby inhibiting tumor growth. The compound is lipophilic, allowing it to easily penetrate cell membranes, and it has a complex structure featuring multiple cyclic ether rings. Salinomycin is typically administered in low doses to minimize toxicity while maximizing its therapeutic effects. However, its use is regulated due to potential side effects and the development of resistance in target organisms. Overall, salinomycin's unique properties and mechanisms of action make it a significant compound in both veterinary and biomedical research.

Formula: C₄₂H₆₉NaO₁₁

InChI: InChI=1/C42H70O11.Na/c1-11-29(38(46)47)31-15-14-23(4)36(50-31)27(8)34(44)26(7)35(45)30(12-2)37-24(5)22-25(6)41(51-37)19-16-32(43)42(53-41)21-20-39(10,52-42)33-17-18-40(48,13-3)28(9)49-33;/h16,19,23-34,36-37,43-44,48H,11-15,17-18,20-22H2,1-10H3,(H,46,47);/q;+1/p-1/t23-,24-,25+,26-,27-,28-,29+,30-,31+,32+,33+,34+,36+,37-,39-,40+,41?,42-;/m0./s1

InChI key: InChIKey=KQXDHUJYNAXLNZ-XQSDOZFQSA-N

SMILES: O[C@H]1[C@]2(O[C@@]3(O[C@]([C@H](C([C@H]([C@H]([C@H](C)[C@@]4(O[C@@]([C@H](C(O)=O)CC)(CC[C@@H]4C)[H])[H])O)C)=O)CC)([C@@H](C)C[C@H]3C)[H])C=C1)O[C@@](C)(CC2)[C@@]5(O[C@@H](C)[C@](CC)(O)CC5)[H]

Synonyms:

• (2R)-2-((5S)-6-{5-((10S,12R)-2-((6S,5R)-5-Ethyl-5-Hydroxy-6-Methylperhydro-2H-Pyran-2-Yl)-15-Hydroxy-2,10,12-Trimethyl-1,6,8-Trioxadispiro(4.1.5.3)Pentadec-13-En-9-Yl)(1S,2S,3S,5R)-2-Hydroxy-1,3-Dimethyl-4-Oxoheptyl}-5-Methylperhydro-2H-Pyran-2-Yl)Butanoic Acid
• (2R)-2-{(5S,6R)-6-[(2S,3S,4S,6R)-6-{(2S,5R,7S,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl}-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyltetrahydro-2H-pyran-2-yl}butanoic acid
• 1,6,8-Trioxadispiro[4.1.5.3]pentadecane, salinomycin deriv.
• Antibiotic 61477
• Coxistac
• Stereoisomer of α-ethyl-6-[5-[2-(5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl]-2-hydroxy-1,3-dimethyl-4-oxoheptyl]tetrahydro-5-methyl-2H-pyran-2-acetic acid
• sodium (2R)-2-{(2R,5S,6R)-6-[(1S,2S,3S,5R)-5-{(2S,5S,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl}-2-hydroxy-1,3-dimethyl-4-oxoheptyl]-5-methyltetrahydro-2H-pyran-2-yl}butanoate
• Salinomycin
• SALINOMYCIN GRANULE
• SV sodium salt,2,5 salinomycin hydrate
• Salinomycin Premix 12%
• SALINOMYCIN SODIUM
• SALINOMYCIN SODIUM SALT
• SALINOMYCIN 90%

Salinomycin

CAS: 53003-10-4

Salinomycin

Formula: C₄₂H₇₀O₁₁

Purity: 98%

Color and Shape: white lyophilized solid

Molecular weight: 751.00g/mol

Ref: 54-BIM0200

Salinomycin

CAS: 53003-10-4

Salinomycin

Purity: ≥95%

Molecular weight: 751g/mol

Ref: 54-BUP03611

Salinomycin

CAS: 53003-10-4

Formula: C₄₂H₇₀O₁₁

Purity: ≥ 98%

Color and Shape: White or off-white crystalline powder or crystals

Molecular weight: 751.00

Ref: 7W-GA5900

Salinomycin

CAS: 53003-10-4

Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, specifically inhibits the growth of gram-positive bacteria.

Formula: C₄₂H₇₀O₁₁

Purity: 97.34% - 97.48%

Color and Shape: White Powder

Molecular weight: 751

Ref: TM-T0906

Salinomycin

CAS: 53003-10-4

Formula: C₄₂H₇₀O₁₁

Molecular weight: 751.01

Ref: 4Z-S-242

Salinomycin

CAS: 53003-10-4

Stability Hygroscopic
Applications Salinomycin is a potassium ionophore antibiotic. Studies showed that Salinomycin can selectively kill breast cancer stem cells.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Garcia-Rubino, M. E., et al.: Anticancer Agents Med Chem. 16, 1230 (2016); Boesch, M., et al.: Stem Cells Transl Med 4, 1028 (2015)

Formula: C₄₂H₇₀O₁₁

Color and Shape: White To Light Yellow

Molecular weight: 751.00

Ref: TR-S088700

Salinomycin

CAS: 53003-10-4

Purity: 98%

Molecular weight: 751.0109863

Ref: 10-F812826