CAS 53016-31-2

Norelgestromin

Description:

Norelgestromin is a synthetic progestin, primarily used in hormonal contraceptives. It is a derivative of the natural hormone progesterone and is characterized by its ability to mimic the effects of progesterone in the body. Norelgestromin is known for its high oral bioavailability and is often administered transdermally via patches, allowing for sustained release into the bloodstream. The substance has a molecular formula that reflects its complex structure, which includes multiple rings and functional groups that contribute to its hormonal activity. Norelgestromin functions by inhibiting ovulation, altering the endometrial lining, and thickening cervical mucus, thereby preventing pregnancy. Its pharmacokinetics involve metabolism primarily in the liver, and it is excreted through urine. The compound is generally well-tolerated, but like all medications, it may have side effects and contraindications that should be considered. Overall, Norelgestromin plays a significant role in reproductive health, particularly in contraceptive formulations.

Formula: C₂₁H₂₉NO₂

InChI: InChI=1S/C21H29NO2/c1-3-20-11-9-17-16-8-6-15(22-24)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23-24H,3,5-12H2,1H3/t16-,17+,18+,19-,20-,21-/m0/s1

InChI key: InChIKey=ISHXLNHNDMZNMC-XUDSTZEESA-N

SMILES: C(C)[C@@]12[C@]([C@]3([C@](CC1)([C@@]4(C(CC3)=CC(=NO)CC4)[H])[H])[H])(CC[C@]2(C#C)O)[H]

Synonyms:

• (17a)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one Oxime
• (8R,9S,10R,13S,14S,17R)-13-ethyl-17-ethynyl-3-(hydroxyimino)-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-ol (non-preferred name)
• 17-Deacetylnorgestimate
• 17-Deacylnorgestimate
• 18,19-Dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, oxime, (17α)-
• 18-Methylnorethindrone oxime
• <span class="text-smallcaps">D</span>-Norgestrel 3-oxime
• Brn 4202099
• D-Norgestrel 3-oxime
• Levonorgestrel 3-oxime
• Levonorgestrel oxime
• Norplant 3-oxime
• Rwj 10553
• d-(17α)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one oxime

Norelgestromin

CAS: 53016-31-2

Estrogens and progestins

Formula: C₂₁H₂₉NO₂

Color and Shape: White Off-White Powder

Molecular weight: 327.21983

Ref: 45-1468454

DEACETYLNORGESTIMATE (25 MG) ((E)- AND (Z)-17-DEACETYL NORGESTIMATE MIXTURE)

CAS: 53016-31-2

Formula: C₂₁H₂₉NO₂

Purity: 99%

Molecular weight: 327.4605

Ref: IN-DA00DANW

Norgestimate metabolite Norelgestromin

CAS: 53016-31-2

Norgestimate metabolite Norelgestromin (17-Deacylnorgestimate), an active metabolites of norgestimate, is a steroidal progestin used in contraceptive patches.

Formula: C₂₁H₂₉NO₂

Purity: 99.64%

Color and Shape: Solid

Molecular weight: 327.46

Ref: TM-T16338

Norgestimate EP Impurity C and Norgestimate EP Impurity D (17-Desacetyl Norgestimate, Norelgestromin)

CAS: 53016-31-2

Formula: C₂₁H₂₉NO₂

Color and Shape: White To Off-White Solid

Molecular weight: 327.47

Ref: 4Z-N-121

Norgestimate EP Impurity C-d7 and Norgestimate EP Impurity D-d7 (17-Desacetyl Norgestimate-d7, Norelgestromin-d7)

CAS: 53016-31-2

Formula: C₂₁H₂₂D₇NO₂

Color and Shape: White To Off-White Solid

Molecular weight: 334.51

Ref: 4Z-N-126

Norgestimate metabolite Norelgestromin

CAS: 53016-31-2

Norgestimate metabolite Norelgestromin

Purity: ≥98%

Molecular weight: 327.46g/mol

Ref: 54-BUP11259

Norgestimate EP Impurity C

Controlled Product

CAS: 53016-31-2

Formula: C₂₁H₂₉NO₂

Color and Shape: Neat

Molecular weight: 327.46

Ref: 86-MM0978.01

(E/Z)-17-Deacetylnorgestimate

Controlled Product

CAS: 53016-31-2

Formula: C₂₁H₂₉NO₂

Color and Shape: Neat

Molecular weight: 327.46

Ref: TR-D288721

17-Desacetyl norgestimate

Controlled Product

CAS: 53016-31-2

17-Desacetyl norgestimate is a contraceptive drug that is administered as a transdermal patch. It is used to prevent pregnancy by inhibiting ovulation and interfering with the production of progesterone, which is needed for the maintenance of pregnancy. Norgestimate binds to the progesterone receptor in the uterus and prevents implantation of a fertilized egg. 17-Desacetyl norgestimate has been shown to be effective in preventing pregnancies in women who are not using other hormonal contraceptives. This drug also has an anti-inflammatory effect on ovarian tissue, which may be due to its inhibition of pro-inflammatory cytokines such as IL-1β and TNFα.

Formula: C₂₁H₂₉NO₂

Purity: Min. 95%

Color and Shape: Off-White Solid

Molecular weight: 327.46 g/mol

Ref: 3D-FD21125

Deacetylnorgestimate ((E)- and (Z)-17-deacetyl norgestimate mixture) (DISCONTINUED)

CAS: 53016-31-2

Estrogens and progestins

Formula: C₂₁H₂₉NO₂

Color and Shape: White Powder

Molecular weight: 327.21983

Ref: 45-1471958