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CAS 53123-88-9

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Rapamycin

Description:
Rapamycin, also known as sirolimus, is a macrolide compound with the CAS number 53123-88-9. It is produced by the bacterium *Streptomyces hygroscopicus* and is primarily known for its immunosuppressive properties, making it valuable in organ transplantation to prevent rejection. Rapamycin functions by inhibiting the mammalian target of rapamycin (mTOR), a key regulator of cell growth, proliferation, and survival. This inhibition leads to a reduction in T-cell activation and proliferation. In addition to its immunosuppressive effects, rapamycin has garnered attention for its potential anti-cancer properties and its role in promoting longevity in various model organisms. The compound is typically administered orally and has a relatively long half-life, allowing for sustained therapeutic effects. However, it can have side effects, including increased risk of infections, metabolic disturbances, and potential lung toxicity. Due to its complex pharmacokinetics, monitoring of blood levels is often necessary to optimize dosing and minimize adverse effects.
Formula:C33H31NO2
InChI:InChI=1/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12-,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38?,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
InChI key:InChIKey=QFJCIRLUMZQUOT-HPLJOQBZSA-N
SMILES:O=C1N2[C@](C(=O)O[C@]([C@@H](C[C@H]3C[C@@H](OC)[C@H](O)CC3)C)(CC(=O)[C@H](C)/C=C(\C)/[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(/C)\[C@@H](OC)C[C@]4(O[C@@](O)(C1=O)[C@H](C)CC4)[H])[H])(CCCC2)[H]
Synonyms:
  • (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-
  • (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
  • (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
  • (3S,6R,7E,9R,10R,12R,14S,15Z,17E,19E,21S,26R,27R,34aS)-9,27-dihydroxy-3-{(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
  • 14S-Rapamycin
  • 23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-(3-(4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-, (3S-(3R*S*1R*,3S*,4S*)),6S*,7E,9S*,10S*,12S*,14R*,15E,17E,19E,21R*,23R*,26S*,27S*,34aR*))-
  • 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, rapamycin deriv.
  • 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-, [3S-[3R*[S*(1R*,3S*,4S*)],6S*,7E,9S*,10S*,12S*,14R*,15E,17E,19E,21R*,23R*,26S*,27S*,34aR*]]-
  • 6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
  • Antibiotic AY 22989
  • See more synonyms
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products per page.Found 25 products.
  • Rapamycin

    CAS:
    Formula:C51H79NO13
    Purity:>95.0%(HPLC)
    Color and Shape:White to Almost white powder to crystal
    Molecular weight:914.19

    Ref: 3B-R0097

    25mg
    75.00€
  • Rapamycin, 98+%

    CAS:
    Rapamycin, 53123-88-9, also known as Sirolimus, is a macrolide which exhibits antitumor and immunosuppressive activity. Learn more at Thermo Fisher Scientific.
    Formula:C51H79NO13
    Purity:98+%
    Color and Shape:White to cream to yellow, Powder or crystals or crystalline powder
    Molecular weight:914.19

    Ref: 02-J62473

    50mg
    187.00€
    100mg
    242.00€
    200mg
    302.00€
  • Sirolimus

    CAS:
    Antibiotics nesoi
    Formula:C51H79NO13
    Color and Shape:Off-White White Powder
    Molecular weight:913.55514
  • Rapamycin

    CAS:
    Formula:C51H79NO13
    Purity:98%
    Color and Shape:Solid
    Molecular weight:914.1719

    Ref: IN-DA0035KC

    25g
    To inquire
    1mg
    24.00€
    5mg
    25.00€
    100mg
    28.00€
    250mg
    44.00€
    500mg
    63.00€
    1g
    82.00€
    5g
    200.00€
    10g
    428.00€
    50g
    1,223.00€
    100g
    2,113.00€
    250g
    4,752.00€
  • Rapamycin

    CAS:
    Rapamycin, a macrolide from Streptomyces hygroscopicus, inhibits mTOR (IC50: 0.1 nM) and promotes autophagy with immunosuppressive effects.
    Formula:C51H79NO13
    Purity:97.08% - 99.97%
    Color and Shape:White Solid
    Molecular weight:914.17

    Ref: TM-T1537

    10mg
    34.00€
    25mg
    46.00€
    1mL*10mM (DMSO)
    48.00€
    50mg
    50.00€
    100mg
    65.00€
    200mg
    101.00€
    500mg
    178.00€
    1g
    268.00€
  • Rapamycin

    CAS:
    Rapamycin
    Formula:C51H79NO13
    Purity:≥95%
    Color and Shape:Solid
    Molecular weight:914.17

    Ref: 54-BUP17166

    10mg
    53.00€
    25mg
    64.00€
    50mg
    76.00€
    100mg
    96.00€
    200mg
    163.00€
    500mg
    273.00€
  • Rapamycin

    CAS:
    Formula:C51H79NO13
    Purity:98.0 - 102.0 % (anhydrous basis)
    Color and Shape:White to yellow crystalline powder
    Molecular weight:914.17

    Ref: 7W-GA7417

    5mg
    35.00€
    25mg
    83.00€
    50mg
    155.00€
    100mg
    255.00€
  • Rapamycin from Streptomyces hygroscopicus

    CAS:
    Rapamycin from Streptomyces hygroscopicus
    Formula:C51H79NO13
    Purity:By hplc: 99.14% (Typical Value in Batch COA)
    Color and Shape:White Solid-Powder
    Molecular weight:914.17186

    Ref: 54-BIR8101

    500mg
    127.00€
    1g
    211.00€
    5g
    738.00€
  • Rapamycin (Sirolimus, Everolimus EP Impurity A)

    CAS:
    Formula:C51H79NO13
    Color and Shape:White To Off-White Solid
    Molecular weight:914.19

    Ref: 4Z-R-182

    5mg
    To inquire
    100mg
    To inquire
    10mg
    343.00€
    25mg
    436.00€
    50mg
    623.00€
  • Rapamycin

    CAS:
    Formula:C51H79NO13
    Purity:95%~99%
    Molecular weight:914.187

    Ref: BP-BP1196

    ne
    To inquire
  • Rapamycin (Standard)

    CAS:
    Rapamycin (Standard) is a reference standard for research and analysis in studies involving Rapamycin. Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy.
    Formula:C51H79NO13
    Color and Shape:Solid
    Molecular weight:914.17

    Ref: TM-TMSM-3400

    50mg
    135.00€
  • Rapamycin

    CAS:
    (3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
    Formula:C51H79NO13
    Purity:98%
    Molecular weight:914.17
  • Everolimus EP Impurity A

    CAS:
    Formula:C51H79NO13
    Molecular weight:914.2

    Ref: ST-EA-CP-E33001

    10mg
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    25mg
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    50mg
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    100mg
    To inquire
  • Rapamycin

    CAS:
    Formula:C51H79NO13
    Molecular weight:914.19

    Ref: ST-EA-CP-R26000

    10mg
    To inquire
    25mg
    To inquire
    50mg
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    100mg
    To inquire
  • Rapamycin

    CAS:

    Applications A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants. It has shown its efficacy against neurodegenerative diseases including Alzheimer's and Parkinson's.
    References Martel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977), Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1993), Kahan, B.D., et al.: Lancet, 356, 194 (2000), Holmes, D.R., et al.: Circulation, 109, 634 (2004),

    Formula:C51H79NO13
    Purity:>85%
    Color and Shape:Neat
    Molecular weight:914.17

    Ref: TR-R124000

    5mg
    111.00€
    50mg
    408.00€
    100mg
    750.00€
  • Rapamycin-13C,d3 (contains d0) Technical Grade

    Controlled Product
    CAS:

    Applications Labelled Rapamycin. A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic.This compound contains aproximately 2% d0.
    References Martel, P.R., et al.: Can. J. Physiol. Pharmacol., 55, 48 (1977), Carlson, R.P., et al.: J. Pharmacol. Exp. Ther., 266, 1125 (1993), Kahan, B.D., et al.: Lancet, 356, 194 (2000), Holmes, D.R., et al.: Circulation, 109, 634 (2004),

    Formula:C50CH76D3NO13
    Color and Shape:Neat
    Molecular weight:918.18

    Ref: TR-R124003

    1mg
    602.00€
    5mg
    2,246.00€
    10mg
    4,322.00€
  • Rapamycin - Bio-X ™

    CAS:

    Rapamycin is a macrolide antibiotic that has been studied as a potential anticancer agent. It binds to FK506 binding proteins (FKBPs) to form a complex that inhibits mammalian targets of rapamycin (mTOR). Rapamycin also blocks p70 S6 kinase activation by interleukin-2 and thereby inhibits proliferation of T cells. It induces differentiation of human pluripotent stem cells (hPSCs) to mesendoderm and blood progenitor cells.

    Formula:C51H79NO13
    Purity:Min. 95%
    Color and Shape:Powder
    Molecular weight:914.17 g/mol

    Ref: 3D-BR164324

    10mg
    185.00€
  • Ref: BE-RMCR019012

    1mg
    28.00€
  • Ref: BE-MU-7122YA-1000

    1ml
    62.00€