Nisoxetine is a chemical compound classified as a selective norepinephrine reuptake inhibitor (NRI), primarily known for its potential use in the treatment of attention deficit hyperactivity disorder (ADHD) and depression. It is characterized by its ability to enhance norepinephrine levels in the synaptic cleft by inhibiting its reuptake into presynaptic neurons, which can lead to increased neurotransmission and improved mood and focus. The molecular structure of nisoxetine includes a phenoxy group, contributing to its pharmacological properties. It is typically administered in oral form and has been studied for its efficacy and safety profile in various clinical settings. As with many psychotropic medications, nisoxetine may have side effects, including insomnia, dry mouth, and increased heart rate, which necessitate careful monitoring during treatment. Its chemical properties, such as solubility and stability, are important for formulation and therapeutic use. Overall, nisoxetine represents a significant area of interest in neuropharmacology, particularly for conditions related to norepinephrine dysregulation.

Nisoxetine

53179-07-0: Nisoxetine is a chemical compound classified as a selective norepinephrine reuptake inhibitor (NRI), primarily known for its potential use in the treatment of attention deficit hyperactivity disorder (ADHD) and depression. It is characterized by its ability to enhance norepinephrine levels in the synaptic cleft by inhibiting its reuptake into presynaptic neurons, which can lead to increased neurotransmission and improved mood and focus. The molecular structure of nisoxetine includes a phenoxy group, contributing to its pharmacological properties. It is typically administered in oral form and has been studied for its efficacy and safety profile in various clinical settings. As with many psychotropic medications, nisoxetine may have side effects, including insomnia, dry mouth, and increased heart rate, which necessitate careful monitoring during treatment. Its chemical properties, such as solubility and stability, are important for formulation and therapeutic use. Overall, nisoxetine represents a significant area of interest in neuropharmacology, particularly for conditions related to norepinephrine dysregulation.

<p>Nisoxetine is a selective NET (noradrenaline transporter) inhibitor (Kd=0.76 nM) capable of blocking voltage-gated sodium channels.</p>

CAS 53179-07-0

Nisoxetine

Nisoxetine

Ref: TM-T69145