CAS 53179-09-2

sisomicin sulfate

Description:

Sisomicin sulfate is an aminoglycoside antibiotic that is primarily used to treat infections caused by Gram-negative bacteria. It is derived from the fermentation of Micromonospora purpurea and exhibits a broad spectrum of antibacterial activity. Sisomicin functions by inhibiting bacterial protein synthesis, specifically targeting the 30S ribosomal subunit, which disrupts the translation process and ultimately leads to cell death. The compound is typically administered parenterally due to its poor oral bioavailability. Its solubility in water is enhanced by the sulfate form, making it suitable for intravenous use. Sisomicin is known for its potential nephrotoxicity and ototoxicity, which necessitates careful monitoring of renal function and hearing in patients receiving treatment. Additionally, it may exhibit synergistic effects when used in combination with other antibiotics, enhancing its efficacy against resistant bacterial strains. As with other aminoglycosides, dosage adjustments may be required in patients with renal impairment to minimize the risk of adverse effects.

Formula: C₁₉H₃₉N₅O₁₁S

InChI: InChI=1/2C19H37N5O7.5H2O4S/c2*1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;5*1-5(2,3)4/h2*3,9-18,24-27H,4-7,20-23H2,1-2H3;5*(H2,1,2,3,4)/t2*9?,10-,11+,12-,13+,14+,15-,16+,17?,18+,19-;;;;;/m00...../s1

InChI key: InChIKey=JVTNJDPXUPRGIE-XMKQNZKISA-N

SMILES: O([C@@H]1[C@@H](O)[C@H](O[C@H]2OC(CN)=CC[C@H]2N)[C@@H](N)C[C@H]1N)[C@@H]3[C@H](O)[C@@H](NC)[C@@](C)(O)CO3.S(=O)(=O)(O)O

Synonyms:

• (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside sulfate (2:5)
• 4,6-diamino-3-{[3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)pentopyranoside sulfate (2:5) (salt)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</smallcap>-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-<smallcap>D</span>-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-, sulfate (2:5)
• <span class="text-smallcaps">D</smallcap>-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-<smallcap>L</smallcap>-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-<smallcap>D</span>-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-, sulfate (2:5) (salt)
• Antibiotic 66-40 sulfate
• Baymicin
• Extramycin
• Mensiso
• Sisobiotic
• Sisolline
• Sisomicin Sulphate
• Sisomin
• Sisomycin sulfate
• Sissomicin sulfate
• D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-, sulfate (2:5) (salt)
• Sisomicin sulfate
• D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-glycero-hex-4-enopyranosyl-(1→4)]-2-deoxy-, sulfate (2:5)
• 6)-o-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-d-glycero-hex-4-enopyranosyl-(1-4))
• Sisomicin sulfate, >=580 μg/mg
• Sisomicin Sulfate (500 mg)
• Sisomicin sulfate, >98%
• antibiotic66-40sulfate
• D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(16)-O-[2,6-diamino-2,3,4,6-tetradeoxy-a-D-glycero-hex-4-enopyranosyl-(14)]-2-deoxy-, sulfate (2:5) (salt) (9CI)
• SISOMYCIN SULPHATE
• O-3-Deoxy-4-C-methyl-3-methylamino-ss-L-arabinopyranosyl-(1->6)-O-[2, 6-diamino-4, 5-dehydro-2,3,4,6-tetradeoxy-a-D-glycero-hexopyranosyl-(1->4)]-2-deoxy-D-streptamine hemiheptasulfate
• Disisomicinpentakis(sulfat)
• SisoMicin Sulfate Salt, USP
• pathomycin
• O-3-Deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-glycero-hex-4-enopyranosyl-(1-4)]-2-deoxy-D-streptamine sulfate
• O-3-DEOXY-4-C-METHYL-3-METHYLAMINO-BETA-L-ARABINOPYRANOSYL-(1->6)-O-[2, 6-DIAMINO-4,5-DEHYDRO-2,3,4,6-TETRADEOXY-A-D-GLYCERO-HEXOPYRANOSYL-(1->4)]-2-DEOXY-D-STREPTAMINE HEMIHEPTASULFATE
• Sisomicin sulfate, 580 IU/mg
• Sulfuric acid west shuttle m star
• Sisomycin Sulfate USP/EP/BP
• Sisomicin sulfate CRS
• SISOMICIN SULFATE SALT
• disisomicin pentakis(sulphate)

Sisomicin sulfate, 90%

CAS: 53179-09-2

Sisomicin sulfate, 90%

Formula: C₁₉H₃₉N₅O₁₁S

Purity: 90%

Color and Shape: White to off-white, Powder

Molecular weight: 545.61

Ref: 02-J66063

SISOMICIN SULFATE CRS

CAS: 53179-09-2

SISOMICIN SULFATE CRS

Formula: C₃₈H₈₄N₁₀O₃₄S₅

Color and Shape: Powder. White.

Molecular weight: 1385.445

Ref: 41-S0660000

FIRST INTERNATIONAL STANDARD FOR SISOMICIN

CAS: 53179-09-2

FIRST INTERNATIONAL STANDARD FOR SISOMICIN

Formula: C₃₈H₈₄N₁₀O₃₄S₅

Molecular weight: 1385.445

Ref: 41-ISA_80_543

Sisomicin Sulfate

CAS: 53179-09-2

Aminoglycoside antibiotics

Formula: (C₁₉H₃₇N₅O₇)₂·5H₂SO₄

Color and Shape: Light Yellow Powder

Molecular weight: 894.5386

Ref: 45-1612801

Sisomicin Sulfate

CAS: 53179-09-2

Sisomicin sulfate (Pathomycin), a broad-spectrum antibiotic from Micromonospora inyoensis, is strongest against gram-positive bacteria.

Formula: C₁₉H₃₇N₅O₇·5H₂SO₄

Purity: 580IU - 99.83%

Color and Shape: Solid

Molecular weight: 1385.43

Ref: TM-T1219

Sisomicin Sulfate Salt

CAS: 53179-09-2

Formula: C₃₈H₈₄N₁₀O₃₄S₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 1385.4452

Ref: IN-DA00DEIP

Sisomicin sulfate salt

CAS: 53179-09-2

Formula: C₁₉H₃₇N₅O₇·5H₂SO₄

Purity: ≥ 580μg/mg (C19H37N5O7, dried basis)

Color and Shape: White crystalline powder

Molecular weight: 692.72

Ref: 7W-GA7855

Sisomicin Sulfate

Controlled Product

CAS: 53179-09-2

Formula: C₁₉H₃₇N₅O₇H₂O₄S

Color and Shape: Neat

Molecular weight: 1385.45

Ref: 86-MM3385.00

Sisomycin sulfate

Controlled Product

CAS: 53179-09-2

Formula: C₁₉H₃₇N₅O₇H₂O₄S

Color and Shape: Neat

Molecular weight: 1385.45

Ref: 04-C16970805

Sisomicin Sulfate

CAS: 53179-09-2

Formula: C₁₉H₃₇N₅O₇·5H₂O₄S

Molecular weight: 2 447.54 5 98.08

Ref: 4Z-S-080001

Sisomicin Sulfate Salt

Controlled Product

CAS: 53179-09-2

Applications Sisomicin Sulfate Salt is an aminoglycoside antibiotic displaying a broad spectrum antibiotic activity.
References Cai, Y. et al.: J. Chrom. A., 1085, 124 (2005); Krezel, A. et al.: Bioorg. Med. Chem., 12, 4075 (2004);

Formula: C₁₉H₃₇N₅O₇·5H₂O₄S

Color and Shape: White

Molecular weight: 1385.45

Ref: TR-S488505

Sisomicin sulfate

CAS: 53179-09-2

Sisomicin sulfate is a sulfate salt form of sisomicin with similar action and applications as sisomicin.

Formula: C₁₉H₃₇N₅O₇·5H₂SO₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 1,385.45 g/mol

Ref: 3D-AS33969

Sisomicin Sulfate

CAS: 32385-11-8, 53179-09-2

Formula: C₁₉H₃₇N₅O₇H₂SO₄

Purity: >98.0%(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 692.71

Ref: 3B-I1049