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CAS 53179-11-6

:

Loperamide

Description:
Loperamide is an opioid receptor agonist primarily used as an antidiarrheal medication. It works by slowing down gut movement, which decreases the number of bowel movements and makes the stool less watery. Chemically, Loperamide is characterized by its structure, which includes a piperidine ring and a phenyl group, contributing to its pharmacological properties. It is poorly soluble in water but has better solubility in organic solvents, which affects its absorption and bioavailability. Loperamide is known for its low potential for abuse compared to other opioids, as it does not readily cross the blood-brain barrier in significant amounts. Common side effects may include constipation, dizziness, and nausea. It is important to use Loperamide as directed, as excessive use can lead to serious complications, including toxic megacolon or cardiac issues. Overall, Loperamide is a valuable medication for managing acute and chronic diarrhea, particularly in non-infectious cases.
Formula:C29H33ClN2O2
InChI:InChI=1S/C29H33ClN2O2/c1-31(2)27(33)29(24-9-5-3-6-10-24,25-11-7-4-8-12-25)19-22-32-20-17-28(34,18-21-32)23-13-15-26(30)16-14-23/h3-16,34H,17-22H2,1-2H3
InChI key:InChIKey=RDOIQAHITMMDAJ-UHFFFAOYSA-N
SMILES:C(CCN1CCC(O)(CC1)C2=CC=C(Cl)C=C2)(C(N(C)C)=O)(C3=CC=CC=C3)C4=CC=CC=C4
Synonyms:
  • 4-(4-Chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-1-piperidinebutanamide
  • Adl 2-1294
  • Loperamid
  • Loperamida
  • Loperamide
  • 4-(p-Chlorophenyl)-4-hydroxy-N,N-dimethyl-a,a-diphenyl-1-piperidinebutyramide
  • MeSH ID: D008139
  • 53179-11-6
  • 5-21-02-00379 (Beilstein Handbook Reference)
  • 1-Piperidinebutanamide, 4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-α,α-diphenyl-
  • See more synonyms
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Found 2 products.
  • Loperamide Hydrochloride
    TCI
    + Info

    Loperamide Hydrochloride

    CAS:
    Formula:C29H33ClN2O2·HCl
    Purity:>98.0%(T)(HPLC)
    Color and Shape:White to Almost white powder to crystal
    Molecular weight:513.50

    Ref: 3B-L0154

    5g
    110.00€
    25g
    372.00€
  • Loperamide
    Biosynth
    + Info

    Loperamide

    Controlled Product
    CAS:
    <p>Loperamide is a drug that has been approved for the treatment of diarrhea. It is a synthetic opioid that binds to opioid receptors in the gut, slowing intestinal motility and increasing the time food stays in the stomach. Loperamide has not shown long-term toxicity or any significant cardiac effects. It also does not affect matrix production or polymerase chain reaction (PCR) activity. Loperamide is a chemical inhibitor of monoethyl ethers, which are used in non-steroidal anti-inflammatory drugs (NSAIDs). Loperamide can be used for the treatment of bowel disease with few drug interactions and disease activity.</p>
    Formula:C29H33ClN2O2
    Purity:Min. 95%
    Color and Shape:Solid
    Molecular weight:477.04 g/mol

    Ref: 3D-FL65067

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