CAS 53230-10-7: Mefloquine

Description: Mefloquine is an antimalarial drug primarily used for the prevention and treatment of malaria, particularly in areas where the disease is resistant to other treatments. It is classified as a quinoline derivative and exhibits a unique mechanism of action by interfering with the parasite's ability to metabolize hemoglobin, leading to its death. Mefloquine is typically administered orally and is known for its long half-life, allowing for once-weekly dosing in prophylactic use. The compound is characterized by its lipophilic nature, which facilitates its distribution in body tissues. Common side effects include gastrointestinal disturbances, neuropsychiatric symptoms, and potential cardiovascular effects. Due to its side effect profile, mefloquine is not recommended for individuals with a history of seizures or certain psychiatric disorders. Its efficacy and safety profile make it a valuable option in malaria-endemic regions, although careful consideration of patient history is essential before prescribing. Mefloquine's chemical structure includes a chiral center, contributing to its pharmacological properties and interactions within the body.

Formula: C₁₇H₁₆F₆N₂O

InChI: InChI=1/C17H16F6N2O/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11/h3-5,8,12,15,24,26H,1-2,6-7H2/t12-,15+/s2

InChI key: InChIKey=XEEQGYMUWCZPDN-OPNJQGHXNA-N

SMILES: FC(F)(F)C1=NC2=C(C=CC=C2C(F)(F)F)C(=C1)C(O)C3NCCCC3

Synonyms:

• WR 142490
• Mephaquin
• Mefloquina
• rel-(αS)-α-(2R)-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol
• Mefloquinum
• (S)-[2,8-Bis(trifluoromethyl)-4-quinolinyl][(2R)-2-piperidinyl]methanol
• Mefloquine
• (S)-[2,8-Bis(trifluoromethyl)quinolin-4-yl][(2R)-piperidin-2-yl]methanol
• (R*,S*)-(±)-a-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol
• Mefloquine
• 4-Quinolinemethanol, α-2-piperidinyl-2,8-bis(trifluoromethyl)-, (R*,S*)-(±)-
• 4-Quinolinemethanol, α-(2R)-2-piperidinyl-2,8-bis(trifluoromethyl)-, (αS)-rel-
• 4-quinolinemethanol, alpha-[(2R)-2-piperidinyl]-2,8-bis(trifluoromethyl)-, (alphaS)-
• (R)-[2,8-bis(trifluoromethyl)quinolin-4-yl][(2S)-piperidin-2-yl]methanol
• Mefloquine [USAN:BAN:INN]

Mefloquine Hydrochloride

CAS: 51773-92-3 53230-10-7

• Formula: C₁₇H₁₆F₆N₂O·HCl
• Purity: >98.0%(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 414.78

Mefloquine

CAS: 53230-10-7

Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.

• Formula: C₁₇H₁₆F₆N₂O
• Purity: 99.97%
• Color and Shape: Solid
• Molecular weight: 378.31

Mefloquine

CAS: 53230-10-7

• Purity: 99.97%
• Molecular weight: 378.31g/mol

Mefloquine

CAS: 53230-10-7

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• Formula: C₁₇H₁₆F₆N₂O
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 378.31 g/mol