CAS 533-45-9

Clomethiazole

Description:

Clomethiazole, with the CAS number 533-45-9, is a thiazole derivative primarily recognized for its sedative and anxiolytic properties. It appears as a white to off-white crystalline powder and is soluble in water and alcohol, which facilitates its use in various formulations. The compound acts as a central nervous system depressant, often utilized in the management of alcohol withdrawal symptoms and as a sedative in certain medical contexts. Clomethiazole functions by enhancing the effects of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits neuronal excitability, thereby promoting relaxation and sleep. However, its use is associated with potential side effects, including respiratory depression and dependence, necessitating careful monitoring. Due to its pharmacological profile, clomethiazole is typically prescribed with caution, and its use may be restricted in some regions. Overall, while effective in specific therapeutic scenarios, the safety profile of clomethiazole requires thorough consideration in clinical practice.

Formula: C₆H₈ClNS

InChI: InChI=1/C6H8ClNS.ClH/c1-5-6(2-3-7)9-4-8-5;/h4H,2-3H2,1H3;1H

InChI key: InChIKey=PCLITLDOTJTVDJ-UHFFFAOYSA-N

SMILES: C(CCl)C1=C(C)N=CS1

Synonyms:

• 4-Methyl-5-(β-chloroethyl)thiazole
• 5-(2-Chloroethyl)-4-Methyl-1,3-Thiazole Hydrochloride
• 5-(2-Chloroethyl)-4-Methylthiazole
• 5-(β-Chloroethyl)-4-methylthiazole
• Chlorethiazol
• Chlorethiazole
• Chlormethiazol
• Chlormethiazole
• Clomethiazolum
• Distraneurin
• Emineurina
• Somnevrin
• Thiazole, 5-(2-chloroethyl)-4-methyl-
• Clomethiazole
• ChlormethiazoleHCl
• CHLORMETHIAZOLE HYDROCHLORIDE (5-(2-CHLOROETHYL)-4-METHYLTHIAZOLE)

Chlormethiazole Hydrochloride

CAS: 533-45-9, 6001-74-7

Formula: C₆H₈ClNS·HCl

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 198.11

Ref: 3B-C3020

Clomethiazole

CAS: 533-45-9

Formula: C₆H₈ClNS

Purity: 99%

Color and Shape: Liquid

Molecular weight: 161.6524

Ref: IN-DA00DE16

Clomethiazole

CAS: 533-45-9

Clomethiazole (Distraneurin) is an orally active GABAA agonist and it is an anticonvulsant agent. It has potential for treating convulsive status epilepticus.

Formula: C₆H₈ClNS

Purity: 99.06%

Color and Shape: Solid

Molecular weight: 161.65

Ref: TM-T14983

Clomethiazole

CAS: 533-45-9

Clomethiazole

Purity: 99%

Molecular weight: 161.65g/mol

Ref: 54-OR953028

Clomethiazolum

CAS: 533-45-9

Formula: C₆H₈ClNS

Molecular weight: 161.65

Ref: 4Z-C-272001

Clomethiazole-d7

CAS: 533-45-9

Formula: C₆HD₇ClNS

Molecular weight: 168.69

Ref: 4Z-C-272002

Chlormethiazole

Controlled Product

CAS: 533-45-9

Sedative and hypnotic; used in treatment of acute alcohol withdrawal

Formula: C₆H₈ClNS

Purity: Min. 95%

Color and Shape: Colorless Powder

Molecular weight: 161.65 g/mol

Ref: 3D-FC16096

Clomethiazolum

Controlled Product

CAS: 533-45-9

Applications Clomethiazolum is a drug which is structurally related to thiamine (vitamin B1) but acts like a sedative, hypnotic, muscle relaxant and anticonvulsant.
References Reilly, T.M., Birt. J. Psyc., 128, 375 (1976); Reith, D.M. et al.: Clinic. Toxi., 41, 975 (2003);

Formula: C₆H₈ClNS

Color and Shape: Neat

Molecular weight: 161.65

Ref: TR-C587020

5-(2-Chloroethyl)-4-methylthiazole

CAS: 533-45-9

Formula: C₆H₈ClNS

Purity: 97%

Color and Shape: Solid

Molecular weight: 161.65

Ref: 10-F049113

Clomethiazolum-d4

Controlled Product

CAS: 533-45-9

Applications Clomethiazolum-d4 is derived from Formamide (F691480), which is a compound that used in biochemistry to prevent RNA samples from degradation due to RNAses. Formamide is also used as a plasticizer to prepare thermoplastic starch (TPS), a special type of starch that can be mixed with other synthetic polymers because of its unique ability to “flow”. Also it the isotopically labelled analog of Clomethiazolum (C587020), a sedative, hypnotic, muscle relaxant and anticonvulsant.
References Chomczynski, P.: Nuc. Acids Res., 20, 3791 (1992); Ma, X. & Yu, J.: Acta Polym. Sinica 2, No vol. given, 240 (2004); Rodriguez-Gonzalez, F., et al.: Polymer, 44, 1517 (2003); Shi, Q., et al.: Polym. Degrad. Stabil., 96, 175 (2011); Reilly, T.M., Birt. J. Psyc., 128, 375 (1976); Reith, D.M. et al.: Clinic. Toxi., 41, 975 (2003);

Formula: C₆D₄H₄ClNS

Color and Shape: Neat

Molecular weight: 165.677

Ref: TR-C587022