CAS 533-45-9
:Clomethiazole
Description:
Clomethiazole, with the CAS number 533-45-9, is a thiazole derivative primarily recognized for its sedative and anxiolytic properties. It appears as a white to off-white crystalline powder and is soluble in water and alcohol, which facilitates its use in various formulations. The compound acts as a central nervous system depressant, often utilized in the management of alcohol withdrawal symptoms and as a sedative in certain medical contexts. Clomethiazole functions by enhancing the effects of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits neuronal excitability, thereby promoting relaxation and sleep. However, its use is associated with potential side effects, including respiratory depression and dependence, necessitating careful monitoring. Due to its pharmacological profile, clomethiazole is typically prescribed with caution, and its use may be restricted in some regions. Overall, while effective in specific therapeutic scenarios, the safety profile of clomethiazole requires thorough consideration in clinical practice.
Formula:C6H8ClNS
InChI:InChI=1/C6H8ClNS.ClH/c1-5-6(2-3-7)9-4-8-5;/h4H,2-3H2,1H3;1H
InChI key:InChIKey=PCLITLDOTJTVDJ-UHFFFAOYSA-N
SMILES:C(CCl)C1=C(C)N=CS1
Synonyms:- 4-Methyl-5-(β-chloroethyl)thiazole
- 5-(2-Chloroethyl)-4-Methyl-1,3-Thiazole Hydrochloride
- 5-(2-Chloroethyl)-4-Methylthiazole
- 5-(β-Chloroethyl)-4-methylthiazole
- Chlorethiazol
- Chlorethiazole
- Chlormethiazol
- Chlormethiazole
- Clomethiazolum
- Distraneurin
- Emineurina
- Somnevrin
- Thiazole, 5-(2-chloroethyl)-4-methyl-
- Clomethiazole
- ChlormethiazoleHCl
- CHLORMETHIAZOLE HYDROCHLORIDE (5-(2-CHLOROETHYL)-4-METHYLTHIAZOLE)
- See more synonyms
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Found 10 products.
Chlormethiazole Hydrochloride
CAS:Formula:C6H8ClNS·HClPurity:>98.0%(T)(HPLC)Color and Shape:White to Almost white powder to crystalMolecular weight:198.11Clomethiazole
CAS:<p>Clomethiazole (Distraneurin) is an orally active GABAA agonist and it is an anticonvulsant agent. It has potential for treating convulsive status epilepticus.</p>Formula:C6H8ClNSPurity:99.06%Color and Shape:SolidMolecular weight:161.65Chlormethiazole
CAS:Controlled Product<p>Sedative and hypnotic; used in treatment of acute alcohol withdrawal</p>Formula:C6H8ClNSPurity:Min. 95%Color and Shape:Colorless PowderMolecular weight:161.65 g/mol5-(2-Chloroethyl)-4-methylthiazole
CAS:Formula:C6H8ClNSPurity:97%Color and Shape:SolidMolecular weight:161.65Clomethiazolum
CAS:Controlled Product<p>Applications Clomethiazolum is a drug which is structurally related to thiamine (vitamin B1) but acts like a sedative, hypnotic, muscle relaxant and anticonvulsant.<br>References Reilly, T.M., Birt. J. Psyc., 128, 375 (1976); Reith, D.M. et al.: Clinic. Toxi., 41, 975 (2003);<br></p>Formula:C6H8ClNSColor and Shape:NeatMolecular weight:161.65Clomethiazolum-d4
CAS:Controlled Product<p>Applications Clomethiazolum-d4 is derived from Formamide (F691480), which is a compound that used in biochemistry to prevent RNA samples from degradation due to RNAses. Formamide is also used as a plasticizer to prepare thermoplastic starch (TPS), a special type of starch that can be mixed with other synthetic polymers because of its unique ability to “flow”. Also it the isotopically labelled analog of Clomethiazolum (C587020), a sedative, hypnotic, muscle relaxant and anticonvulsant.<br>References Chomczynski, P.: Nuc. Acids Res., 20, 3791 (1992); Ma, X. & Yu, J.: Acta Polym. Sinica 2, No vol. given, 240 (2004); Rodriguez-Gonzalez, F., et al.: Polymer, 44, 1517 (2003); Shi, Q., et al.: Polym. Degrad. Stabil., 96, 175 (2011); Reilly, T.M., Birt. J. Psyc., 128, 375 (1976); Reith, D.M. et al.: Clinic. Toxi., 41, 975 (2003);<br></p>Formula:C6D4H4ClNSColor and Shape:NeatMolecular weight:165.677
