CAS 533-48-2

Desthiobiotin

Description:

Desthiobiotin, with the CAS number 533-48-2, is a biotin analog that plays a significant role in biochemical research, particularly in studies involving biotinylation and protein labeling. It is characterized by its structural similarity to biotin, lacking the ureido group that is present in biotin, which affects its biological activity. Desthiobiotin is a white to off-white solid that is soluble in water and organic solvents, making it versatile for various laboratory applications. Its primary use is in the development of affinity tags for proteins, as it can bind to avidin or streptavidin with high affinity, albeit lower than that of biotin. This property allows researchers to utilize desthiobiotin in techniques such as pull-down assays and protein purification. Additionally, desthiobiotin can be used in the synthesis of biotinylated compounds, facilitating the study of protein interactions and cellular processes. Overall, desthiobiotin serves as a valuable tool in molecular biology and biochemistry, enabling the exploration of complex biological systems.

Formula: C₁₀H₁₈N₂O₃

InChI: InChI=1S/C10H18N2O3/c1-7-8(12-10(15)11-7)5-3-2-4-6-9(13)14/h7-8H,2-6H2,1H3,(H,13,14)(H2,11,12,15)/t7-,8+/m0/s1

InChI key: InChIKey=AUTOLBMXDDTRRT-JGVFFNPUSA-N

SMILES: C(CCCCC(O)=O)[C@@H]1[C@H](C)NC(=O)N1

Synonyms:

• Biotin, dethio-
• Desthiobiotin
• 4-Imidazolidinehexanoic acid, 5-methyl-2-oxo-, (4R-cis)-
• (4R,5S)-5-Methyl-2-oxo-4-imidazolidinehexanoic acid
• 4-Imidazolidinehexanoic acid, 5-methyl-2-oxo-, (4R,5S)-

D-Desthiobiotin

CAS: 533-48-2

D-Desthiobiotin

Purity: ≥98%

Molecular weight: 214.26g/mol

Ref: 54-BUP11741

6-((4R,5S)-5-Methyl-2-Oxoimidazolidin-4-Yl)Hexanoic Acid

CAS: 533-48-2

6-((4R,5S)-5-Methyl-2-Oxoimidazolidin-4-Yl)Hexanoic Acid

Purity: 98%

Molecular weight: 214.26g/mol

Ref: 54-OR1011938

6-((4R,5S)-5-Methyl-2-oxoimidazolidin-4-yl)hexanoic acid

CAS: 533-48-2

Purity: 97%

Molecular weight: 214.26499938964844

Ref: 10-F868804

D-Desthiobiotin

CAS: 533-48-2

D-Desthiobiotin, a biotin derivative for affinity/protein chromatography, cell labeling, and separation.

Formula: C₁₀H₁₈N₂O₃

Purity: 99.88% - 99.90%

Color and Shape: Solid

Molecular weight: 214.26

Ref: TM-T19259

Desthiobiotin

CAS: 533-48-2

Formula: C₁₀H₁₈N₂O₃

Molecular weight: 214.27

Ref: 4Z-B-2758

D-Desthiobiotin

CAS: 533-48-2

Applications D-Desthiobiotin is an analogue of Biotin (B389040) that binds less tightly to biotin-binding proteins such as Avidin and is easily displaced by Biotin.
References Wang, J., et al.: Proteins: Struct., Funct., Genet., 34, 69 (1999); Hirsch, J., et al.: Anal. Biochem., 308, 343 (2002);

Formula: C₁₀H₁₈N₂O₃

Color and Shape: Neat

Molecular weight: 214.262

Ref: TR-D297663

Desthiobiotin

CAS: 533-48-2

Formula: C₁₀H₁₈N₂O₃

Molecular weight: 214.27

Ref: ST-EA-CP-B78023

D-Desthiobiotin

CAS: 533-48-2

For affinity capture via the biotin-streotavidin interaction.

Formula: C₁₀H₁₈N₂O₃

Purity: Area-% Min. 95 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 214.26 g/mol

Ref: 3D-FD161565